mice 2 9

Tag: "mice" at biology news

New research identifies gene important for nicotine's effects on the brain

...ciotto's research used both genetically engineered mice with altered nicotine receptors and viruses that could block CREB function. She and her colleagues showed that one type of nicotine receptor was important for both CREB activity and nicotine reward and that blocking CREB in the nucleus accumbens was ...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

... of radiation to the entire body. In the study, mice were used to test the protective effects of mangan.... The researchers found that in a control group of mice that received an initial 9 Gy dose of radiation there was 80 percent survival at 30 days compared to...

How mammals fuel milk production may have implications for cancer

...nown as Akt is specifically required for lactating mice to synthesize sufficient quantities of milk to sup...manent activation of Akt1 in the mammary glands of mice leads to early lipid accumulation during pregnancy, raising the possibility that the gene might be i...

Eating protein boosts hormone that staves off hunger

...er reduction of hunger. Further investigation in mice supported the human study results. High-protein di...n, the researchers found that genetically modified mice unable to produce PYY ate more and became markedly obese. The genetically modified mice were also re...

Vaccination with embryonic stem cells prevents lung cancer in mice

...rchers in America have discovered that vaccinating mice with embryonic stem cells prevented lung cancer in...n 80-100% effective in preventing tumour growth in mice that were subsequently challenged with transplanted Lewis lung carcinoma, and it was between 60-90% ...

Who gives stem cells their marching orders?

...venting them from differentiating too early. Using mice engineered to carry an altered form of the protein, the ISREC group showed that if this switch is blocked, Nodal has the opposite effect: it triggers a cascade of molecular signals which stimulate differentiation. In an article appearing in the Sep...

Researchers identify a key regulator for skin stem cells

...stem cells. They found that activating the gene in mice blocked differentiation of all three types of mature skin cells -- epidermal, sebaceous, and hair follicle. "We've known for some time that Tcf3 can operate with a co-factor called â-catenin and initiate skin stem cells to make hair follicles. But we...

Novel pathway regulates timing of brain cell development

...of the neural stem cell. Corfas's team showed that mice lacking erbB4 produced astrocytes earlier in embryonic development than normal. ErbB4 is activated by another protein called neuregulin 1 (NRG1), and then is cut in two by a third critical protein called presenilin, the researchers showed. The half o...

New technology to speed up research into Huntington's disease

...fective new method of testing cognitive decline in mice with the disease, using an automated touch screen....ts demand a level of physical performance that the mice cannot deliver due to the effect of the disease on their motor abilities. The automated screen d...

RNA map provides first comprehensive understanding of alternative splicing

...argets, and validating their results in "knockout" mice that were missing Nova. In the new study, Darnell, with co-first authors Jernej Ule and Giovanni Stefani, took these 50 RNA transcripts and searched them for clusters of sequences they had previously identified as Nova binding sites through bioche...

Natural protein stops deadly human brain cancer in mice

...hat they can inhibit lethal human brain cancers in mice using a protein that selectively induces positive ...injected these treated cells into mouse brains. In mice injected with cells that were not pretreated, large, invasive cancers grew. In the mice with BMP4-tr...

Studies find general mechanism of cellular aging

...embered their "age" even when transferred from old mice to young mice. The cells of mice bred without the gene showed less sluggishness as the animals aged and continued to function in a ma...

Researchers create mouse lacking key inflammation gene

...ere induced at lower levels in the LITAF-deficient mice compared with the levels observed in the LITAF-positive control mice. Specifically, the deficient mice were more resistant to LPS-induced lethality. "The generation of the macrophage-specific LITAF-de...

Researchers identify new weapon to fight deadly bacterial sepsis

...ead author Ramana and their collaborators injected mice with lipopolysaccharide (LPS) to produce the condi...ory signaling molecules. But when they treated the mice with an aldose reductase inhibitor, they found that blocking the enzyme's activity restored the hear...

'Erectile dysfunction' drugs heighten natural anti-cancer activity

...Hopkins Kimmel Cancer Center. Tests at Hopkins on mice with implanted colon and breast tumors showed that...reefold in sildenafil-treated animals, compared to mice that did not get the drug. In mice engineered to lack an immune system, tumors were unaffected, proo...

Study illuminates how the plague bacteria causes disease

...y caused significantly fewer problems for infected mice compared to normal bacteria. "Earlier studies that focused only on the protein's kinase activity had missed half the picture," Stebbins said. "The GDI domain seems to have an even bigger effect on host cells in culture, and a significant impact on v...

Knockout Mouse Project

...effort to produce thousands of genetically altered mice for a study to understand the role of individual g...e the functions of 10,000 mouse genes. Humans and mice share the same characteristics for most of the 10,000 mouse genes identified for this study. Resear...

Drug can quickly mobilize an army of cells to repair injury

...ich tested the effect of both AMD3100 and G-CSF in mice after blood flow to a leg had been impaired. Both drugs induced new blood vessels to grow in the affected legs of the mice, and combining the drugs had the greatest benefit. "We are now working to set up a clinical trial to test G-CSF in patients wi...

'Best of both worlds' -- Targeting a single gene could inhibit bone decay and stimulate bone growth

...dy shows that the inactivation of gene Atp6v0d2 in mice results in dramatically increased bone mass due to defective osteoclasts as well as enhanced bone formation. These findings may provide some clarity into the regulation of bone metabolism and show that targeting the function of a single gene could po...

Key gene controlling kidney development found

...t. Jude team showed that the kidneys in developing mice lacking the Six2 gene were remarkably smaller than normal mice and were non-functional at birth. In addition, they produced an abnormal excess in the number of nep...

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