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Tag: "mice" at biology news

White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

...ss works and found that white blood cells in these mice overwhelm normal defenses of cancer cells. In a r...aid that several types of white blood cells in the mice attack cancer cells by sensing, finding and surrounding them, forming a "rosette," and then killing ...

Single molecule extends fat mice lives by reversing gene pathways associated with disease in obese

...f the changes in gene expression patterns found in mice on high calorie diets--some of which are associate.... "The "healthspan" benefits we saw in the obese mice treated with resveratrol, such as increased insulin sensitivity, decreased glucose levels, healthier...

Gene key to taste bud development identified

...the developing tongue." The particular strain of mice that Hogan and her colleagues use had been developed by Larysa Pevny, Ph.D., a geneticist and developmental neurobiologist at the University of North Carolina at Chapel Hill, who is co-author with Hogan of the journal report. In engineering her new...

Cloned mice created from fully differentiated cells, a milestone in cloning research

...he researchers compared the efficiency for cloning mice using a fully differentiated blood cell called a granulocyte with its ancestor cells at different stages: hematopoietic stem cells, which are found in bone marrow and give rise to all red and white blood cells, and progenitor cells. Granulocytes are ...

Encouraging results in pancreatic cancer research

...er a two-week period in the peritoneal cavities of mice containing simultaneously transplanted tumors, PNC-28 caused complete destruction of these tumors. When delivered concurrently with tumor implantation, PNC-28 completely blocked tumor growth during the two-week period of administration and two wee...

Interaction between lymph and liver cells may affect immune response

...ps between LSECs. The study was conducted using mice whose livers had been injected with lymphocytes. The mouse livers were examined with two types of electron microscopy. Analysis of the images showed a large number of intrahepatic lymphocytes (IHLs) that had extensions similar to the dimensions of th...

Growth factor stimulates rapid extension of key motor neurons in brain

... of neuronal survival. Tests in living developing mice showed that blocking the IGF-1 pathway in the spinal cord prevented the growth of CSMN axons, which confirmed the applicability of the in vitro experiments to living mammals. "The role of IGF-1 as a potent and specific enhancer of CSMN axon growt...

Signal protein shows promise for blocking tumor promoters in skin cells

... effects of Src kinases. They developed strains of mice with high levels of Srcasm, which had normal skin,...recursors of cancer. Breeding experiments with the mice indicated that high Srcasm levels counteracted the effects of Fyn. The findings reveal that leve...

Neuron cell stickiness may hold key to evolution of the human brain

...tudy comparing the genomes of humans, chimpanzees, mice and other vertebrates, researchers at the U.S. Dep...f human neurons compared to the neurons of chimps, mice and other animals, could help explain why the human brain is capable of far more complex cognitive f...

Chronic jet-lag conditions hasten death in aged mice

Researchers have found that aged mice undergoing weekly light-cycle shifts--similar to t...nced significantly higher death rates than did old mice kept on a normal daylight schedule over the same eight-week period. The findings may not come as a g...

The effects of smoking on fractures and ligament injuries

...ts of smoking on fractures and ligament healing in mice and found that healing of both types of injury was...icine in St. Louis, MO the first study involved 35 mice divided into a smoking group, which was exposed to cigarette smoke 6 days per week for a month, and ...

MRSA toxin acquitted: Study clears suspected key to severe bacterial illness

...VL present. These findings were seen in tests with mice that displayed skin and soft-tissue infection and ... RML. "Unexpectedly, the average abscess volume in mice infected with strains absent the PVL was slightly greater than those containing the toxin. The stron...

New approach to BSE successful in lab

...eak of the disease. As yet there is no cure. In mice suffering from scrapie the pathogenic prion protei...e effect in diseases like a stroke. Interestingly, mice which cannot produce any PrP-C appear to be completely healthy. This has become the starting point f...

Male contraception: One door opens, another closes

...ising contraceptive that didn't make the leap from mice to men is miglustat (trade name Zavesca) (Human Re...hat it was acting as a contraceptive in their male mice at a tenth of the disease-treatment dose. With safety testing already out of the way, they thought t...

Einstein researchers demonstrate a novel approach to treating AIDS

... HIV, the virus that causes AIDS. "This study in mice supports the idea that radioimmunotherapy might he...ues; and the absence of an immune system meant the mice could not mount an immune attack against the "foreign" human white blood cells.) One hour later, th...

Researchers seek to design first treatment for neuroAIDS

...tures. CNND researchers will test the compounds in mice with HAD to determine that they work in a living system genetically similar to humans. If these tests are successful, human studies will proceed with an existing MLK3 inhibitor, CEP-1347, developed by Pennsylvania-based biotech Cephalon. Ira Shoulso...

Tarantula venom and chili peppers target same pain sensor

... to cause pain by exciting the same nerve cells in mice that sense high temperatures and the hot, spicy in...entists report. Their finding, based on studies of mice cells in culture and live mice, is published in the November 9 issue of the journal Nature. The seni...

Transplanted photoreceptor precursor cells restore visual function in mice with retinal degeneration

...ls called photoreceptors directly into the eyes of mice and restored their visual function. The achieve...rs were transplanted into three different types of mice with retinal degeneration caused by distinct genetic defects involving malfunctioning or degeneratin...

Scientists show drug can counteract muscular dystrophy in mice

... drug can rebuild damaged muscle in two strains of mice that develop diseases comparable to two human form...hy. At 45 to 90 days of age, the muscles of the MD mice showed much fibrous tissue and infiltration of inflammatory cells. Unlike healthy mice, the mice wi...

Scientists discover way to block growth of prostate cancer cells

...onged survival and inhibited tumour development in mice that were genetically engineered to spontaneously ... They injected MDL into the genetically engineered mice and found that it inhibited polyamine oxidation and reduced oxidative stress in the prostate glands ...

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