Protein may hold key to decreasing organ dysfunction rates in heart transplants
...Inflammation was found to decrease dramatically in mice in which the production of Lcn-2 was genetically d...o found elevated levels of Lcn-2 in the kidneys of mice that had undergone heart transplants, suggesting the protein's possible involvement in the systemic ...Blocking immune cell action increases Alzheimer's-associated protein deposits
...he CCR2 gene had been deleted. They found that mice lacking CCR2 had significantly more amyloid-beta in their brains than did the Alzheimer's-model mice that retained the molecule. These deposits were primarily found in small blood vessels ?similar to ...Reactivated gene shrinks tumors
...ave shown that re-activating one of those genes in mice can cause tumors to shrink or disappear. The stu... In this study, the researchers used engineered mice that had the gene for p53 turned off. But, they also included a genetic "switch" that allowed the re......out the antigen, the researchers then injected the mice with a large number of OVA antigen-specific T cells. What happened after the day of transfer? As expected, only the tumour with the OVA antigen disappeared, after about a week. In the interval, the two-photon microscope (see box) made it possibl...Turning a cellular sentinel into a cancer killer
...d p53 in the mice, they genetically engineered the mice so that they could reverse p53 inactivation by giv...ory. When the researchers reactivated p53 in the mice they found that the liver tumors completely disappeared. "This was quite surprising," said Lowe. "We...Anti-fungal drug stops blood vessel growth
...its availability as an antiangiogenesis drug. In mice induced to have excess blood vessel growth, treatment with itraconazole reduced blood vessel growth by 67 percent compared to placebo. “We were surprised, to say the least, that itraconazole popped up as a potential blocker of angiogenesis,?says Jun ...MIT: Pulsing light silences overactive neurons
...plans to start studying such devices in transgenic mice this year. The group also plans to use the new method to study neural circuits. Last year, Boyden devised a technique to stimulate neurons by shining blue light on them, so with blue and yellow light the researchers can now exert exquisite control...Cancer scientists create 'human' leukemia process to map how disease begins, progresses
...he converted cells, when transplanted into special mice that permit the growth of human cells, can replica...ls and injected the genetically altered cells into mice that lacked immune systems. The result? 100% of the mice developed fatal leukemia that displayed the...Chemicals in brown algae may protect against skin cancer
...searchers applied the BAPs to the skin of hairless mice and fed it to the animals in their diet. In both c...er and his collaborators used a strain of hairless mice that are particularly susceptible to UVB-induced skin cancer. Nine experimental groups were used, ea...Minuscule molecules pack a powerful punch
... role. Cells of the immune system in the knockout mice do not work as well as normal cells and the mice develop symptoms similar to those of human autoimmune disease. They are also less able to resist inf...Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows
...ound substantially improved learning and memory in mice with Down syndrome symptoms, say researchers at th...Garner’s laboratory. Fernandez found that affected mice were significantly better able to identify novel objects and navigate a maze tasks that simulate d...New insights into autoimmunity and depression
...nction in SLE in particular. Healthy female mice received injections, directly into the brain, of h...LE patient. For control purposes, equal numbers of mice were injected with normal human immunoglobin G. All the mice were then subjected to a series of test...Scientists identify a candidate gene for osteoporosis
...) that exhibited different levels of expression in mice with higher BMD. The analogous chromosomal region...han's team characterized the skeletal phenotype of mice with and without the DARC gene. The DARC -knockout mice exhibited increased BMD and lower bone re...Major link in brain-obesity puzzle found
...nts were performed in mice, including two types of mice that the team altered genetically so that they onl.... Previously, Rui and his team have shown that mice that lack the gene for SH2B1 -- called knockout mice -- become obese, diabetic, and unable to stop e...New research shows why too much memory may be a bad thing
...working memory tests for two independent groups of mice in which neurogenesis in the hippocampus regions was suppressed. Results of the tests, in which mice had to locate food within specific areas of a maze, showed that mice in which neurogenesis had been ...'Exercise pill' switches on gene that tells cells to burn fat
By giving ordinary adult mice a drug - a synthetic designed to mimic fat - Salk ...s the ability of cells to burn fat. Even when the mice are not active, turning on the chemical switch activates the same fat-burning process that occurs du...New approach could lower antibiotic requirements by 50 times
... of hospital-acquired infections. Experiments in mice revealed that 75% of those infected with a lethal dose of Pseudomonas survived if the antibiotic gentamicin was administered in the presence of bacteriophages. None survived without the phages (Microb. Drug Resist., 2006, 12 (3), 164). The bacterio...Research project tackles 'regeneration' gap
...human brain cells can generate new brain tissue in mice and produce large amounts of new brain cells in culture for use as possible replacements for dead or injured cells. The UF project is "bold" because it takes a comprehensive view of regenerative medicine, according to Arlene Y. Chiu, Ph.D., direct......of Neuron. The researchers injected laboratory mice with a decoy peptide containing a snippet of a rec...e. As a test, the researchers then injected the mice with kainic acid, a chemical known to cause seizures and neuron death. While seizures still occur...Studies in mice have indicated that the effects of prion disease c...o neuronal function and survival in prion-infected mice we have shown here support targeting neuronal [prion protein] directly as a therapeutic approach," w...