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Tag: "mice" at biology news

Stem cell transplants explored at Stanford as a possible treatment for hearing loss

...humans, with the goal of first curing deafness in mice within the next five years. His lab is also busy studying the ability of birds to regenerate the tiny hair cells in the cochlea. It's these cells that convert the mechanical energy of sound into electrical impulses that are sent to the brain so th...

Penn researchers replace organ in adult mice using 'single-parent' stem cells

...blood-producing, stem cells that were destroyed in mice exposed to radiation. The Penn researchers first ...tal blood and were able to rescue other irradiated mice with bone marrow transplants from these animals. It is clear proof, according to McLaughlin, that u...

Cancer researchers add spice to research against rare neuromuscular disease

...matically slowed the progression of the disease in mice that carried the mutant human gene that causes the disease. The mice were able to walk much more normally, their muscles were much stronger, and they had near-normal lev...

Jefferson researchers' discovery may change thinking on how viruses invade the brain

...teract) to a virus lacking it. They showed that in mice that were infected with rabies without the LC8 binding domain, the virus was still able to infect the brain, but did not cause disease. The virus?ability to reproduce was greatly diminished. "What we found has nothing to do with transport," Dr. Sc...

Small molecule dervived from Rb2/p130 could act as cancer therapeutic

...lly produced in the laboratory was introduced into mice that had been injected with tumor cells. "Tumor growth was inhibited and the tumors began to reduce in size until they disappeared," Giordano said. Giordano said because of the intrinsic nature of the compound, it can be easily reproduced as a ...

Study uncovers a lethal secret of 1918 influenza virus

... our earlier research showing the host response in mice infected with the 1918 flu, suggests that the host immune response is out of control in animals infected with the virus," said Michael G. Katze, professor of microbiology at the University of Washington in Seattle, who led the functional genomics por...

Active ingredient in common Chinese herb shown to reduce hypertension

...the right renal artery. Sham-operated hamsters and mice underwent the same procedure, except for the place...lied it topically to the hamsters¡¯ cheek pouch or mice cremaster muscles to achieve the final concentration of one ¦Ìg/ml or five ¦Ìg/ml. After the applica...

Antibody signal may redirect inflammation to fuel cancer

.... "If we confirm that what we've discovered in the mice studies also occurs in human cancers, we may soon .... The new UCSF finding comes from studies with mice genetically engineered to carry some of the genes of the human papilloma virus (HPV), a pathogen tha...

Tumor cells evade death through autophagy

...d only in tumor cells not undergoing apoptosis. If mice were unable to initiate autophagy, increased numbe...ing apoptosis were detected. Furthermore, if these mice were treated with the chemotherapeutic agent cyclophosphamide, tumor cell apoptosis and tumor regres...

Scientists identify a gene that may suppress colorectal cancer

...onduct the study, the researchers used a strain of mice that develop polyps, or small growths of tissue, i...estive tract—the harbingers of cancer. When these mice possessed one copy of the mutated gene, the incidence of small intestinal and colon polyps were redu...

Making mice with enhanced color vision

...l of Medicine and their colleagues have found that mice simply expressing a human light receptor in additi...ed this trait to spread quickly. "If you gave mice a new sensory input at the front end, could their brains learn to make use of the extra data at the ...

Pregnancy hormone key to repairing nerve cell damage

...ulty of Medicine reports that a study conducted on mice found that the hormone prolactin encourages the sp...cords of pregnant mice. Further, when non-pregnant mice with MS-like lesions were injected with prolactin, their myelin was also repaired. The research w...

Experience affects new neuron survival in adult brain; study sheds light on learning, memory

... contains the dentate gyrus. After injecting mice with a chemical used to mark proliferating cells, ...r several weeks, the researchers again exposed the mice in the same enriched experience. They discovered that the enriched experience increased new neuron ...

Bacteria research offers hope for new vaccine against meningococci

...em Ann-Beth Jonsson’s research team therefore used mice that produce the human receptor that the bacteria ... cameras to monitor their activities in the living mice during the course of the disease. “The bacteria are almost knocked out by the immune defense syst...

New protein implicated in autism

...Brain Science Institute in Japan demonstrated that mice lacking the protein CADPS2 exhibited autistic-like...igation, Teiichi Furuichi and colleagues show that mice lacking CADPS2, which is encoded by a gene in the autism susceptibility region of human chromosome 7...

MicroRNA helps prevent tumors

... professor Michael Hemann to inject these cells in mice with a compromised immune system. The scientists found that the mice with cells that expressed the version of Hmga2 with the disrupted let-7 sites developed tumors. O...

Viral protein is an effective preventative against infection

...ues at St. Jude show that middle ear infections in mice can be prevented by giving the mice a lysin ?a protein derived from a virus that infects bacteria. The new technology may prevent childr...

Linheng Li Lab documents the development of cancer stem cells

... The Li Lab team studied the intestinal system in mice in which one of the human tumor suppressor genes, PTEN, had been deleted. They found that the PTEN/Akt pathway likely regulates stem cell activation by helping control nuclear localization of beta-catenin, the Wnt pathway effector, through phosphoryl...

Short chromosomes put cancer cells in forced rest

...as stopped in its tracks a form of blood cancer in mice by engineering and inactivating an enzyme, telomer... set of experiments, the research team first mated mice with nonoperating telomerase to mice carrying a mutation that predisposed them to Burkitt’s lymphoma...

Killing the messenger RNA -- But which one?

...e deafness. Working with a strain of transgenic mice unable to perform RNA editing and normal control mice, the researchers found that a complete lack of the edited version of the microRNA in question had the effect of driving production of the PRPS1 enzyme to about double its normal levels. This, in t...

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