mice 2 4

Tag: "mice" at biology news

The sturdier sex? -- Study by Pittsburgh scientists finds female stem cells work better

...and male muscle-derived stem cells into dystrophic mice and then measured the cells?ability to regenerate dystrophin-expressing muscle fibers. They then calculated the regeneration index (RI) ?the ratio of dystrophin-positive fibers per 100,000 donor cells. Only one of the 10 male populations of implan...

Brown cancer biologists identify major player in cell growth

...d out. So he and members of his laboratory created mice that carried a mutation -- tiny DNA sequences were inserted into their GABP-making gene. These DNA bits would serve as a time bomb of sorts, deleting a critical piece of the gene when given a chemical signal. From these mice, Rosmarin and his team...

New player in commitment to life as a fat cell

...red to their normal littermates. Genetically obese mice exhibited increased XOR activity and urate in the adipose tissue. Urate is a salt derived from uric acid. "Our results identify XOR as a potential therapeutic target for metabolic abnormalities beyond hyperuricemia," the researchers said. "To o...

'Guardian of the genome' protein found to underlie skin tanning

... dramatically. When they delivered UV radiation to mice whose keratinocytes lacked p53, POMC production was not induced and the mice did not tan. The implications of the research go beyond tanning. A common skin condition, especia...

'Marathon mice' elucidate little-known muscle type

...o run farther and at higher work loads than normal mice could. The findings could ultimately lead to nove...he gene known as PGC-1â in the skeletal muscles of mice caused them to become crowded with IIX muscle fibers, which are normally much less prevalent. "On...

Enhancing activity of marijuana-like chemicals in brain helps treat

...hashish, helped trigger a dramatic improvement in mice with a condition similar to Parkinson's. "This s...ds in the brain. When they used the combination in mice with a condition like Parkinson's, the mice went from being frozen in place to moving around freel...

How appetite-stimulating brain cells work overtime during fasting

...ake sure that you stay hungry. Now, a new study of mice reported in the January issue of the journal Cell ...appetite-stimulating neurons that express UCP2. In mice that were fasted for 24 hours, the arcuate nucleus showed an increase in the "DII" enzyme's activity...

Stress may help cancer cells resist treatment, research shows

...d has begun studying the effects of epinephrine in mice with prostate cancer....

Fighting influenza & co. with 40,000 blood samples

...llular level in elderly people. Studies with older mice are expected to provide further insights. For these, the University Clinic in Dijon is designing a corresponding animal model. The Belgian project partner RNA-Tec wants to test new approaches on the animals in order to coax maximum performance from t...

Soft-cell approach cuts animal tests

...llion dogs, cats, rabbits, sheep, cattle, pigs and mice are used each year for toxicological testing and research." This is a drop in the ocean, compared with the animal death toll in the rest of the world. In many inhalation studies, the toxicity of airborne chemicals is tested on laboratory animals ...

Genes set scene for metastasis

...reast cancer to the lungs. The study, conducted in mice and reported in this week's Nature, helps to explain how cancer metastasis can occur and highlights targets for therapeutic treatment. Metastasis ?the leading cause of mortality in cancer patients ?entails numerous biological functions that collecti...

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative disease

...rgistic therapies, the investigators then gave the mice a simple oral drug that permitted the amount of en...den of material to metabolize. The lifespan of the mice doubled. (Neither treatment could work as effectively on its own. In fact, the effect was more than ...

A genetic 'gang of 4' drives spread of breast cancer

Studies of human tumor cells implanted in mice have shown that the abnormal activation of four ge...ce the growth and spread of human breast tumors in mice by simultaneously targeting two of the proteins produced by these genes, using drugs already on the ...

Researchers find gene mutation that causes infertility in male mice

...ed. In addition, the researchers found that female mice with the Dmc1 mutation are born with fewer egg cel...on the genetics of fertility stem from analyses of mice that have had a custom gene "knockout," this is the first to reveal a dominant mutation that leads s...

Cold sore virus might play role in Alzheimer's disease

...tivity levels of the herpes virus in the brains of mice with different forms of the human ApoE gene, bring...off focused on while looking at the brain cells of mice with different forms of the ApoE gene. They looked at four groups of mice: Some had ApoE-3, which is...

Link found between immune system and high plasma lipid levels

...ed into the mice, lipid levels rose, both when the mice were fed a regular diet, and also when fed a high-...ays a key role in lipid metabolism. The livers of mice with T cells expressing LIGHT made and secreted much less hepatic lipase ?and consequently, had high...

Liver regeneration may be simpler than previously thought

... samples of mice. The first consisted of embryonic mice at various stages of development while the second was composed of adult mice to which two-thirds of their liver were removed. Using techniques such as DNA microarrays ?which det...

New protein inhibitor impedes growth of cancerous cells

...hat the inhibitor can halt the growth of tumors in mice and cancer-derived cells growing in culture. The findings are reported in companion papers reported by two collaborating groups—one (Lenart et al.) led by Jan-Michael Peters of the Research Institute of Molecular Pathology in Vienna, and the other (S...

Scientists discover new, readily available source of stem cells

...mplanting neural cells created from AFS cells into mice with a degenerative brain disease. The cells grew and "re-populated" the diseased areas. In addition, bone cells produced from the stem cells were successfully used to grow bony tissue in mice, and liver cells were able to secrete urea, which the liv...

Molecular differences between early and advanced melanomas could provide new drug targets

...introduced into immunocompromised (nude) mice, the mice developed aggressive tumors that expressed high levels of VEGF, whereas a control group of mice developed no tumors. Another result of Akt overexpression was the increased production of reacti...

1 2 3 4 5 6 7 8 9 10