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Tag: "mice" at biology news

Herpes infection may be symbiotic, help beat back some bacteria

... Virgin and his colleagues to test herpes-infected mice with exposure to the bacteria Yersinia pestis, whi...vous system. Many aspects of Listeria infection in mice are also similar to those that occur in humans infected with tuberculsis. They found that when mice ...

First demonstration of new hair follicle generation in an animal model

...f Medicine have found that hair follicles in adult mice regenerate by re-awakening genes once active only in developing embryos. These findings provide unequivocal evidence for the first time that, like other animals such as newts and salamanders, mammals have the power to regenerate. These findings are p...

Hexavalent chromium in drinking water causes cancer in lab animals

...rinking water sources. Male and female rats and mice were given four different doses of sodium dichroma...umors in the oral cavity. The studies conducted in mice found increases in the number of benign and malignant tumors in the small intestine, which increased...

Switching genes to overdrive improves muscular dystrophy symptoms in mice

...tch increased the genes?activity in the muscles of mice with Duchenne muscular dystrophy, slowing the dise... increasing levels of PGC-1alpha in the muscles of mice could increase the activity of genes that are known to behave abnormally in muscular dystrophy. P...

Revealing the machinery underlying the 'plastic' juvenile brain

...heir experiments, after keeping juvenile and adult mice in the dark for three days, the researchers expose...ain. They found that the brains of the juvenile mice showed activation of specific genetic mechanisms that the adult brains did not. Specifically, the re...

Biodegradable microspheres deliver time release vaccines, stimulate different immune response

... says Wilson-Welder. The researchers vaccinated mice with microspheres loaded with ovalbumin, a protein... chicken eggs, and measured immune reponse. While mice exhibited the expected antibody response, the researchers also noticed something unexpected. The va...

Deconstructing brain wiring, one neuron at a time

...ces of brain, it is possible to produce transgenic mice that will express specific genes in a targeted class of neurons, Callaway says. "All neurons of the type we select will then express the avian viral receptor and the rabies virus protein, allowing the modified rabies virus to infect targeted cells an...

Researchers wake up viruses inside tumors to image and then destroy cancers

...." To test their findings, the researchers used mice carrying human Burkitt's lymphoma, a cancer often ...ith Epstein-Barr viral infection. Tumors glowed in mice given Velcade followed by an injection of FIAU, but not in mice that weren't given Velcade. Mice who...

It's never too late to get it back! Aging interrupted

...onday 2nd April. Previous research has show that mice can live up to 40% longer if they simply consume fewer calories, but a highly nutritious diet. Because people are not very good at dieting, Dr. Spindler and his colleagues would like to identify drugs which can produce the same beneficial health and...

In young mice, gregariousness seems to reside in the genes

...ound evidence that social interactions among young mice result from basic motivations to be with one anoth...genetic background; it appears to affect how young mice approach social situations." The inbred strains of mice used in the study, once weaned, display m...

Researchers develop marker that identifies energy-producing centers in nerve cells

... The researchers describe how this marker works in mice in the December 20, 2006, issue of The Journal of ... genetic techniques, the researchers have produced mice with fluorescent protein markers that identify only the mitochondria in neurons. These structures li...

Scientists identify pancreatic cancer stem cells

...eded to produce human pancreatic cancer in half of mice tested. They also found these cells are at least 1...mens removed during patient surgery in "xenograft" mice with compromised immune systems. Researchers removed tumors after they grew, and then sorted million...

Blood sugar's manufacture limited by building blocks' supply

...sm, published by Cell Press. The study found that mice deficient for KLF15, a member of the so-called Krü... from an amino acid. The researchers found that mice with a targeted deletion of KLF15 display severe hypoglycemia after an overnight fast. They further ...

Gut research yields new anti-cancer approach

...s where PPARgamma inhibitors killed tumor cells in mice without causing significant toxicity. That provides at least the hope that the drug class may not be prohibitively toxic in humans, the researchers said. More formal toxicity studies are underway. While PPARgamma inhibitors reduce tubulin levels,...

A 'traffic light' for neurons means 'go' for improving brain research

...experiments in living brain tissues extracted from mice at Stanford, the researchers were able to use the technique to cause neurons to signal or stop on the millisecond timescale, just as they do naturally. Other experiments showed that cells appear to suffer no ill effects from exposure to the light. Th...

UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

In experiments with laboratory mice that bear aggressive human breast cancers, UC Davi...traight pin -- into the bloodstreams of laboratory mice bearing human breast tumors. Once in the bloodstream, the probes began to seek out and latch onto re...

In obesity, brain becomes 'unaware' of fat

..., published by Cell Press. These findings in obese mice show that a sensor in the brain that normally dete...y where that breakdown occurs. The researchers fed mice a high-fat diet for 20 weeks, a long time for the mice, which live only for a couple of years. For r...

Scientists identify molecular cause for one form of deafness

...'s F-actin binding sites are linked to deafness in mice and humans. "We found the structure of the bundles changes dramatically when normal espin is replaced with espin mutants that cause deafness," said Gerard Wong, a professor of materials science and engineering, of physics, and of bioengineering at ...

Mutation improves memory, may lead to memory-enhancing pill

A mind-altering mutation in mice results in an enhanced long-term memory, researche...berg and his colleagues previously discovered that mice lacking the enzyme that performs the phosphorylation reaction have a superior ability to remember ne...

Need oxygen? Cells know how to spend and save

...ells all made COX4-2. The researchers then exposed mice to hypoxia for a few weeks and found that they too showed increased levels of COX4-2. In 1992, Semenza's team had discovered a protein which they called HIF-1 (for hypoxia-inducible factor 1) that cells make in response to hypoxia. HIF-1 turns on...

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