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Tag: "mice" at biology news

Statin treatment improves spatial memory in mouse models of Alzheimer's

...spatial memory - how to navigate a water maze - in mice genetically bred to have an Alzheimer’s like disea...ex of statin treated groups as compared to similar mice that did not receive statin. Furthermore, the levels of nNOS proteins were statistically higher in t...

Salk scientists hammer out a pathway that promotes muscle cell survival in mice

...s normal muscle function in genetically engineered mice with weak muscles. The study, published online in ...e interested in the enzyme when they observed that mice engineered to have a defect in a molecular switch, called cAMP responsive element binding protein (C...

Scripps research team sheds light on long-sought cold sensation gene

...the hypothesis, the group observed the behavior of mice genetically altered to lack the gene in response t... where they could choose between two temperatures, mice without TRPM8 showed essentially no preference in the temperature range of 18 to 31°C, suggesting th...

'Insulator' helps silence genes in dormant herpes virus

...searchers now plan to study the HSV-1 insulator in mice to see how the mechanism works to block the communication of gene-activating elements such as enhancers and promoters. The group is also working to identify any additional proteins that may play a role in establishing the insulator. Knowing what g...

Gene malfunctions cause schizophrenia, depression symptoms in mice

...ms of those disorders. They said their findings in mice offer a possible animal model for developing treat...ionally, these symptoms could be alleviated in the mice by antipsychotic drugs. Similarly, the other mutant mouse strain showed behaviors that reflected ...

Peramivir protects mice from lethal H5N1 infection

... studied different approaches to treating infected mice according to duration of administration (one day v...cases, the investigators administered peramivir to mice one hour after nasally administering a lethal Vietnam strain of H5N1 influenza virus. The researc...

Vaccine prevents prion disease in mice

An oral vaccine can prevent mice from developing a brain disease similar to mad cow...ified strain of Salmonella. For the study, the mice were orally vaccinated with a safe, attenuated Salmonella strain, which expressed the prion protein....

Keeping the immune system from starting a 'food fight'

...urrounding the internal organs of STAMP2-deficient mice became inflamed, and the animals developed spontan...ss of STAMP2 exacerbated the metabolic symptoms of mice with a genetic predisposition to obesity due to other factors. When food enters the system, STAMP...

Master regulatory gene of epithelial stem cells identified

...wn tumor-suppressing p53 gene. Without p63, mutant mice run out of the regenerative epithelial stem cells.... cells in these tissues. "With the p63-lacking mice you get normal commitment and differentiation," says McKeon. "The defect is simply running out of st...

Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness

...found that when SNO compounds were administered to mice they could prevent the receptors from being "turned off" by the drugs. The researchers said these findings, if confirmed in humans, open up new avenues for the development of non-desensitizing drugs not only for heart failure and asthma but also f...

Newborn neurons like to hang with the 'in' crowd

...o the existing network of brain cells, at least in mice living in bare standard cages. Providing the mice with a stimulating, enriched environment—large cages filled with running wheels, colored tunnels and...

UQ research heralds vaccine technology breakthrough

...mb to it and die." With preclinical modelling in mice having been encouraging, Professor Tindle said clinical trials were forthcoming, leading the way to the vaccine becoming available in the clinic. He hoped it would become one of the vaccines given to all infants in their first three months of life. ...

Fat screen delivers plant-derived chemical with antidiabetic effects

...ingredient found in some plants fights diabetes in mice without some of the side effects attributed to oth... Further study of harmine's effects in diabetic mice found that the chemical increases insulin sensitivity in a manner similar to, though more roundabout...

Molecule that destroys bone also protects it, new research shows

... Gaffen and colleagues conducted the research in mice bred to have no receptors for IL-17. Other researchers had shown previously, using rats and mice as animal models, that blocking the receptor for IL-17 could be an effective therapy for RA and poss...

Survival of the rarest: Fruit flies shed light on the evolution of behavior

...ene is found in many animals, including honeybees, mice and humans, the researchers are examining how variations in the human foraging gene may be linked to food-related disorders. ...

LIAI scientists make important finding on cytomegalovirus transmission

...ion of the IL-10 protein in the salivary glands of mice by inhibiting binding of IL-10 to its receptor. "...cond approach, which used a stimulator antibody in mice to boost the action of the OX40 protein. OX40 helps T cells replicate more quickly, thus building t...

Researchers publish first marsupial genome sequence

...erences between placental mammals, such as humans, mice and dogs, and marsupial mammals, such as opossums and kangaroos. "Marsupials are the closest living relatives of placental mammals. Because of this relationship, the opossum genome offers a unique lens though which to view the evolution of our ow...

Tissue engineered scaffolding allows reproduction of cartilage tissue

... The procedure was extremely successful in tested mice as the study found these scaffolds to be a far more effective means of regenerating cartilage than traditional therapy. The shrinkage of cartilage that occurs frequently in other tissue engineering methods, and often renders the replacement tissue wr...

Dealing deadly cancers a knockout punch

... Cancer Research Annual Meeting in April, 2007. In mice transplanted with a human colon cancer, Reolysin plus gemcitabine completely eradicated the tumors in four of five test animals. It is rare to see the virtual elimination of tumours as well as the long-lasting therapeutic effect that was observed in...

DNA-damage test could aid drug development

...ng test. Additionally, he experimented with mutant mice created by Samson's lab that are deficient in certain DNA-repair systems. The bone marrow cells derived from these mice, and the cells cultured from that bone marrow, proved more sensitive to the toxic agents than were the cultured cells from normal ...

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