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Tag: "mice" at biology news

Inheritance outside DNA

...amilial histories of colorectal cancer. Turning to mice that modeled the loss of IGF2 imprinting, Feinberg found an increase in frequency of tumors in mice who also had mutations in a cancer-associated gene called Apc. In the mutant Apc mice, the loss of I...

Muscle and bone from an ink-jet printer

...that directed adult muscle-derived stem cells from mice to differentiate into both muscle cells and bone cells. This is the first report of a system that can pattern the formation of multiple tissues from a single population of adult stem cells. Bioengineers from Carnegie Mellon University’s Robotic...

Antibody extends life of mice with breast cancer

...been shown to extend significantly the survival of mice with human breast-cancer tumors and to inhibit the...ious models of cancer metastasis, and, finally, in mice with metastatic breast cancer. "In addition to providing a survival advantage," said Rittenhouse...

Distinguishing friend from foe in the battle against cancer

...an are normal cells. Why cells from these TSC null mice were so poorly equipped to survive was not entirely clear. Co-lead authors Sourav Ghosh, Ph.D., and Vinay Tergaonkar, Ph.D., postdoctoral fellows in the respective Hunter and Verma labs moved those mouse studies to the next level by tinkering with T...

Stem cells found in adult hair follicles may provide alternative to embryonic stem cells

...ersity of Zürich, recently injected these cells in mice with spinal cord injuries. According to the study,...g stem cell markers. "We grafted the cells into mice that have spinal cord injuries and were encouraged by the results. The cells survived and integrated...

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

...ng tumors induced by vinyl carbamate in strain A/J mice New synthetic drugs called triterpenoids which ...ncer cells. They tested CDDO-MA and LG100268 on mice for 20 weeks. CDDO-MA and 268 reduced the number of lung tumors to 9.1 in the group fed CDDO and to ...

Mutant mouse provides insights into breast cancer

...e essential for replicating DNA in both humans and mice that increases the rate of flawed copies of geneti...sts report that by extensively testing hundreds of mice pedigrees, they found a mutant line of mice called Chaos3 that had a 20-fold increase in a hallmark ...

Key to acute lung injury lies in Ang2 protein

...se to hyperoxic acute lung injury (HALI), first in mice and then in human adults and babies. The team found that mice in which the Ang2 gene was genetically eliminated or silenced lived longer and had evidence of decre...

'Trojan Horse' agent halts bone metastasis in mice

...he development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evi... directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis. A week later, they treated the animals with five staggered d...

Research holds promise for herpes vaccine

...ournal, MSU virologist William Halford showed that mice vaccinated with a live, genetically-modified herpe...ain of the virus. In contrast, a second group of mice that received a more conventional vaccine died within six days of being exposed to the same "wild-ty...

Comparing chimp, human DNA

...NA that were highly conserved between chimpanzees, mice and rats. Then they compared those sequences to the human genome sequence, to find pieces of DNA that had undergone the most rapid change since the ancestors of chimps and humans diverged about five million years ago. They found 202 "highly accele...

'Tribbles' protein implicated in common and aggressive form of leukemia

... of evidence implicate Tribbles in AML. First, all mice engineered to express Tribbles-2 (Trib-2) in hemat... to cause leukemia," says Pear. The findings in mice were also validated in a large database of human cancer patients. In a survey of gene expression in ...

Friendly bacteria in alcoholic milkshake could fight food allergies

...e National Formosa University, Yunlin, Taiwan, fed mice the milky drink, and found that after 3 weeks, the amount of ovalbumin (OVA) specific IgE was reduced three-fold. Ovalbumin is an allergenic protein found in egg whites, which cause most allergies in young children. Kefir is also reported to prevent ...

Stanford discovery may help predict when toxoplasma can be deadly

... only recombine in cats, the researchers provided mice infected with different Toxoplasma strains for th...combinant strains from the cats and infected other mice with them. Based on how these mice fared, the researchers could pinpoint stretches of DNA that con...

UVa researchers seek to unlock broccoli's cancer fighting secret

... solidified a link with cancer when she found that mice who did not have the gene for this enzyme developed far fewer cancers when given carcinogens. "If we can determine that this specific enzyme is the reason the compounds in broccoli work to prevent cancer, then these nutrients or similar chemicals ...

Researchers create genetically matched embryonic stem cells for transplantation

...husetts General Hospital used unfertilized eggs of mice to create so-called parthenogenetic embryonic stem cells. Parthenogenesis is a method of reproduction, common in plants and in some animals, in which the female can generate offspring without the contribution of a male. It doesn't normally occur in m...

Experimental cancer drugs counter muscle deterioration seen in muscular dystrophy

...rophies. Indeed, muscles examined from dystrophic mice treated with Trichostatin A for three months displ...ntreated, dystrophic mice. Furthermore, dystrophic mice receiving treatment were able to perform physical exercise (e.g. running on a treadmill) similar to ...

A natural chemical found in strawberries boosts memory in healthy mice

... so-called object discrimination test in mice. The mice get to explore two objects for a certain amount of...f the objects is replaced with a novel one. If the mice remember the object from the day before, they spend less time exploring the old one and instead turn...

Neural stem cells lend the brain a surprising capacity for self-repair

...ng to the researchers. The researchers found that mice whose brains were severely damaged by loss of the ...of California, San Francisco. "We thought that the mice would not live long, but by four weeks, the hole was largely repaired and the animals survived. "...

Experimental vaccine protects mice against deadly 1918 flu virus

... scientists have developed a vaccine that protects mice against the killer 1918 influenza virus. They also... and Prevention (CDC) conducted vaccine studies in mice involving the live, reconstructed 1918 flu virus in a biosafety level 3-enhanced laboratory at the C...

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