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Tag: "mice" at biology news

St. Jude study solves mystery of mammalian ears

... the team developed a line of genetically modified mice that carried only mutant prestin in their outer hair cells. The researchers then tested the animals’ responses to sound. Results of the studies showed no alteration in hearing, which suggested that it did not matter whether the outer hair cells con...

Scratch no more: Gene for itch sensation discovered

...ed by Zhou-Feng Chen, Ph.D., found that laboratory mice that lacked this gene scratched much less than the... signals to the brain. So they began to study some mice that were missing the GRPR gene to find out how they were different from normal mice. "The research...

Agent slows aging in mice

...n August in the journal Aging Cell, show that male mice fed a normal diet and NDGA so far have survived in significantly greater numbers than mice on a normal diet. Scientists measured the difference at a point called median lifespan, when half th...

Enzyme delivered in smaller package protects cells from radiation damage

...nganese superoxide dismutase (MnSOD) could protect mice from whole body irradiation, and in preparation for a potential clinical trial of systemic MnSOD in humans, the University of Pittsburgh and Stanford researchers, led by Joel S. Greenberger, M.D., professor and chair of the department of radiation on...

Brain inflammation may be friend, not foe, for Alzheimer's patients

...Instead, to the team’s surprise, the brains of the mice with IL-1beta stuck in overdrive had only about ha...s engineered mouse, then applied the technology in mice specially designed to develop Alzheimer’s disease. The mice developed normally for six months. Th...

Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring

...okes. Canadian researchers have demonstrated in mice that smoking can cause changes in the DNA sequence...y, studied the spermatogonial stem cells of mature mice that had been exposed to cigarette smoke for either six or 12 weeks to look for alterations in a spe...

Gene therapy delivery of nerve growth factors reverses erectile dysfunction in animal model

...rve growth factor closely related to GDNF. Control mice received only the virus without the GDNF or neurte...h rats treated with the control virus or untreated mice with ED. Rats treated with HSV-neurturin also exhibited significant recovery of ICP and AP compared ...

Hormone helps mice 'hibernate,' survive starvation

A key hormone enables starving mice to alter their metabolism and “hibernate” to conse... Cell Metabolism. FGF21, triggered in starving mice by a specific cellular receptor that controls the use of fat as energy, spurs a metabolic shift to b...

How to lose weight and not go hungry: HU researcher develops drug that mimics feeling of 'fullness'

... hours. Over a 12-day period of daily dosages, the mice weighed 40 percent less than the average for mice of their size and age who were not being given the compound. The peptide has been patented in Eu...

Loss of stem cells correlates with premature aging in animal study

...son we’re seeing the early signs of aging in these mice is that we’re exhausting their ability to renew ti...n the tissues of adult mice, they noticed that the mice showed signs of premature aging, such as hair graying, hair loss, and osteoporosis, within three to ...

Studies to find better ways to preserve human eggs, ovarian tissue under way

...s will put ovarian tissue preserved both ways into mice to see if it survives and starts making proper connections. “The reason for using ovaries is when you have cancer, if you need chemotherapy, you often don’t have time to go through stimulation cycles to get oocytes,” says Dr. Emmi. “You are concen...

In mice, drug protects against diabetes and atherosclerosis

... type 2 diabetes and atherosclerosis in laboratory mice that had been fed unhealthy diets and were genetic...ier studies, Hotamisligil's lab members researched mice lacking two lipid-binding proteins, aP2 and mal1. When these mice were fed a high-cholesterol or hig...

Bacteria ferry nanoparticles into cells for early diagnosis, treatment

.... The researchers also tested their method on live mice and showed how the technique could be used to deliver specific genes to various organs, including the liver and kidneys. "The cells in the organs receiving the bacteria with nanoparticles made the intended therapeutic proteins and emitted a light ...

Herpes virus hijacks DNA repair process

...ctions with other molecules, researchers turned to mice lacking the genes for ATM and H2AX, the damage res... by infection. When they infected cells from these mice with murine herpes virus, its ability to reproduce was again curtailed. How DNA damage response ben...

Research finds that circadian rhythms dominate all life functions

.... For example, while gene expression oscillates in mice exposed to a constant state of dim light or darkness, the groups of genes that typically oscillate together -- such as genes responsible for the function of an organ or a specific tissue -- are chaotic under this state and don't function as a group. ...

Mutating the entire genome

... amount of the total genome,” he adds. Because mice are used to study human disease, “we want to know ...eces of two chromosomes, making it easier to breed mice with human cancers. Such mice are needed to develop new treatments. Vast, Non-Gene Stretches...

Blood-brain barrier breached by new therapeutic strategy

...mall interfering RNA (siRNA), was shown to protect mice from infection caused by the Japanese encephalitis...h the tail veins in one group of mice, while other mice served as control groups. All the mice in the control groups died from JEV infection; in contrast, 8...

'Smart' mice teach scientists about learning process, brain disorders

...searchers said. "It’s pretty rare that you make mice ‘smarter,’ so there are a lot of cognitive implica...eems to have made them smarter." The engineered mice were more adept at learning to navigate a water maze and remembering that being in a certain box inv...

Avian influenza survivors' antibodies effective at neutralising H5N1 strain

...irus are effective at both preventing infection in mice and neutralising the virus in those already infect...at the antibodies provided significant immunity to mice that were subsequently infected with the Vietnam strain of H5N1. This reduced significantly the amou...

Detecting cold, feeling pain: Study reveals why menthol feels fresh

...nts, including menthol. The genetically engineered mice did not discriminate between warm and cold surface... Wisconsin – puts that question to rest. As the mice lacking the gene were not completely insensitive to cold -- they avoided contact with surfaces below...

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