MiRNA fingerprint identified in platelet formation
Scientists have identified a handful of microRNAs (miRNAs) that appear to play a significant role in the development of platelets ?blood cells critical to the body's ability to form clots following an injury. They also say some of these same miRNAs, when acting abnormally, may contribute to certain forms of leukemia. ....Biologists develop genome-wide map of miRNA-mRNA interactions
Researchers at New York University's Center for Comparative Functional Genomics and the University of California, Berkeley have used computational analyses to predict a genome-wide map of microRNA (miRNA) targets in the animal model organism, Caenorhabditis elegans (C. elegans). MicroRNAs bind to messenger RNA (mRNA) in a specific section, called 3'UTR, and are known to regulate them. Parts of th...Dr. Elisa Izaurrralde and colleagues (EMBL; Max-Planck-Institute for Developmental Biology-Tuebingen) provide new mechanistic insight into gene silencing by miRNAs . .. .. Dr. Izaurralde and colleagues demonstrate that the P-body protein, GW182, interacts with the miRNA effector Argonaute proteins as well as mRNA degradation e...