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Tag: "metastatic" at biology news

Newly discovered behavior in cancer cells signals dangerous metastasis

... mesenchymal the cancer cells, the more mobile and metastatic they would be," Garcia-Blanco said. "In reality, aggressive cancer cells are not homogenous, but are extremely versatile in their ability to adapt as their survival needs shift." The researchers discovered this transition in cancer cells when they o...

Vaccine for brain tumors shows promising results

...ions from the Food and Drug Administration in both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). The UCSF clinical trial is a phase1/2 study designed to establish the feasibility, safety and preliminary efficacy of vaccination in patients with recurrent, high-grade glioma. The ...

A fisheye view of the deadliest breast cancer

... small GTPase RhoC that is overexpressed in highly metastatic forms of breast cancer. Using various fluorescent tags, they labeled human MDA breast cancer cells in two ways to mark the parental MDA cells and to mark tumor cells that overexpress RhoC. They injected both tumor cell lines into the immune-suppres...

'Trojan Horse' agent halts bone metastasis in mice

...nted human prostate cancer cells, which are highly metastatic to bone, directly into the leg bone marrow of experimental mice in order to simulate a bone metastasis. A week later, they treated the animals with five staggered doses of VEGF121/rGel delivered through intravenous injections. Half of the treated...

Antibody extends life of mice with breast cancer

...hat is involved in adhesion of the cell during the metastatic process," said Rittenhouse-Olson. "Not only would ...s of cancer metastasis, and, finally, in mice with metastatic breast cancer. "In addition to providing a survival advantage," said Rittenhouse-Olson, "JAA-F11...

Science researchers genetically transform immune cells into tumor fighters

... removing normal T cells from people with advanced metastatic melanoma, genetically engineering these normal cells to carry the receptor that recognizes melanoma cells and returning these "re-armed" cells to rebuild the patients' immune systems. "We can take normal lymphocytes from patients and convert them t...

Reversing cancer cells to normal cells

...ique insights into how scientists can change human metastatic melanoma cells back to normal-like skin cells - by...ew tumors. In fact, with inhibition of Nodal, the metastatic melanoma cells are reverted to a more benign skin cell without the ability to form tumors. Findin...

Nanoparticles for delivery of prostate cancer treatment

...ause the Icon acts through the blood, it can reach metastatic tumors throughout the body, which is critical for ... ?to deliver the therapy in animal models of human metastatic prostate cancer. "While we can directly inject the purified Icon molecule into the bloodstream, ...

Protein found to shield pancreatic cancer cells from self-destruction

...connected TG2 overexpression to drug-resistant and metastatic breast cancer, pancreatic cancer and melanoma. Expression of TG2 is tightly regulated in a healthy cell, Mehta says, and is temporarily increased in response to certain hormones or stress factors. "However, constitutive expression of this protein ...

Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer

...he gene, FUS1, also was found to be active in the metastatic non-small cell lung cancer tumors. "We've treated 13 patients in this first-in-human study and we've seen an exciting proof of concept with no significant drug-related toxicity," says principal investigator Charles Lu, M.D., associate professor in...

Inflammation may play role in metastasis of prostate cancer

...ed with prostate cancer, and one in 33 will die of metastatic disease. Early tumors confined to the prostate ca...ted, but no effective treatments are available for metastatic disease, according to Steven L. Gonias, M.D., Ph.D., professor and chair of the UCSD Department of P...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

... been previously shown to be effective in treating metastatic colorectal cancer. Dr. Laurent-Puig and his c... cancer drug that was recently approved for use in metastatic breast cancer under the name Tykerb. The study, a collaboration with GlaxoSmithKline, evaluated ...

UCSF brain tumor vaccine trial shows promising results

...ons from the Food and Drug Administration for both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). Reviewing the presentation at AANS, Henry Brem, MD, director of neurosurgery at the Johns Hopkins Medical Institutions, noted, “This is an encouraging study of a therapeutic cancer ...

New protein inhibitor impedes growth of cancerous cells

...nical studies of patients with locally advanced or metastatic cancers in order to address the therapeutic potential of the compound. In the companion paper, Lenart et al. use BI 2536 as a tool to probe the functions of Plk1 in normal cells. The availability of a specific Plk1 inhibitor is particularly useful...

Genetic pathways to curable and incurable forms of pancreatic cancer identified

...n of genetic events, and culminate in invasive and metastatic disease that can ultimately kill patients, one route is 100 percent fatal while the other is 50 percent curable," Hingorani said. "Until now we didn't understand why. What these studies suggest is that it's not just the total complement of mutations ...

A genetic 'gang of 4' drives spread of breast cancer

...arget genes. "We found that depriving aggressive metastatic tumor cells of these genes decreased both their ab...d how loss of the four abnormal genes affected the metastatic capability of the cells in the lung. They injected cells deficient in the four genes directly into t...

Genes set scene for metastasis

...coded by these genes may prove useful for treating metastatic breast cancer. ...

Dealing deadly cancers a knockout punch

...sue sarcoma, the lungs are the most common site of metastatic disease. To date, surgery has been the only effective therapy for metastatic sarcoma. The multi-center, Phase II study follows successful completion of systemic administratio...

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