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Tag: "metastatic" at biology news

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...ole new weapon in the fight against tough-to-treat metastatic disease, according to Weill Medical College of Cor...grastatin analogues, prevented 91 to 99 percent of metastatic breast cancer cells in mice, and are the first to target only metastatic cells. "They're unbelievab...

Used in a new way, RNA interference permanently silences key breast cancer gene

...njection or at distant sites typically involved in metastatic breast cancer in this mouse model. Arlinghaus poi...ause of the many problems associated with treating metastatic breast cancer. But he says that proof that RNAi can be used to permanently silence such critical gen...

Nanoparticle Breast Cancer Drug Approved by FDA

...ctable suspension), indicated for the treatment of metastatic breast cancer. "The approval means that women with metastatic breast cancer no longer need to endure the toxicities associated with solvents and will no longer ne...

FDA Works To Speed The Advent Of New, More Effective Personalized Medicines

...velopment of targeted therapies like Herceptin for metastatic breast cancer, Gleevec for chronic myeloid leukemia and Erbitux for metastatic colorectal cancer. "FDA's efforts will bring us one step closer to 'personalizing' medical treatmen...

Turning viruses into allies against cancer

...s to other parts of the body. "This aims to treat metastatic disease and reduce tumor recurrence," said Robert Coffin, Ph.D., chief scientific officer at Biovex Ltd. While this has not been demonstrated in patients, the approach has show promise in pre-clinical studies. In a phase I/II clinical trial, the sci...

Study reveals dramatic difference between breast cancers in US and Africa

...he drug Herceptin, which was recently approved for metastatic breast cancer. It is over-expressed in about 23 percent of Caucasians and 19 percent of Africans. Breast cancer strikes fewer women in Africa, "but it hits earlier and harder," said Olopade. In America, most breast cancer occurs after menopause, usu...

Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer

...or patients with previously untreated recurrent or metastatic breast cancer ?cancer that has spread from the bre... a major advance in the treatment of patients with metastatic disease," said Study Chair Kathy D. Miller, M.D., of the Indiana University Medical Center in Indian...

Disease progression model of pancreatic cancer developed by Penn researchers

...ltiple levels. "In terms of clinical presentation, metastatic burden, and histological changes in tissue, this m...ts are required to create and support invasive and metastatic disease, we hope to translate our findings into better therapies," states Hingorani. The study was ...

Unchecked DNA replication drives earliest steps toward cancer

...s or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An important scientific question, and one with significant clinical implications, has been what happens after the initial mutation that leads to dangerous late...

Characterizing Skin Cancer by Microarrays

...ng in increased risk of metastasis. However, some metastatic tumors retained a gene expression pattern characteristic of the radial growth phase, which implies that both radial and vertical melanomas can metastasize. The authors identified over 2,000 genes that distinguished the stages of melanoma progression....

NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma

...timulated, white blood cells can have an impact on metastatic melanoma tumors in patients who do not respond to other therapies. "The results of this study are encouraging, and suggest that some patients with melanoma who do not respond to conventional treatments may get a durable benefit from treatments based ...

New understanding of cell movement may yield ways to brake cancer's spread

...priate cell migration, including the types seen in metastatic cancer cells." ...

Scientists turn tobacco against cancer

...rectal cancer cells and have been used in treating metastatic disease and in preventing recurrence in certain high-risk patients. But the technology to produce large amounts of antibody is expensive, and researchers would like to find alternatives. Dr. Koprowski, Dr. Ko and their co-workers had previously shown...

Treatments have same target, different responses for lung cancer patients with genetic mutation

... cetuximab, which is approved for the treatment of metastatic colorectal cancers that overexpress EGFR. Cetuximab targets EGFR by preventing its activation by extracellular signals, or signals occurring outside of the cell, as opposed to the intra-cellular signal blocking of drugs like gefitinib. The researc...

Columbia scientists develop cancer terminator viruses

... an anti-tumor immune response against the distant metastatic cancer cells. In the PNAS paper, Dr. Fisher and the team describe the production of a virus conceptually similar to the "terminator" virus, which selectively replicates and kills breast cancer cells in mice. Human breast tumor xenografts were estab...

Vaccine targets tumors where they live

...being designed to battle cancer, but their use for metastatic melanoma is a challenge. Effective vaccines against established tumors require tumor-reactive T cells to traffic to the sites of the tumors and are locally activated there in order to kill cancer cells. A problem is that the T cells lose their tumor-...

Breast tumors in mice eradicated using cancer vaccine

... an alternative and more humane way of controlling metastatic disease than current chemotherapies." The Listeria vector is currently being prepared for a clinical trial targeting a tumor antigen associated with cervical cancer by Advaxis Inc., a cancer vaccine biotech company that has licensed Penn patents on ...

Optimizing cell therapy against tumors is a balancing ACT

...nsfer (ACT) therapy is used to treat patients with metastatic solid tumors. ACT involves the removal of some of the patient's cancer cells, and some of their immune T cells. When the cells are mixed together, specific parts of the cancer cells that stimulate the T cells to cause an immune attack can be identifi...

Eleven gene 'signature' reliably predicts cancer prognosis

...ly displays a stem cell-like expression profile in metastatic tumors in a mouse cancer model as well as metastatic tumors from prostate cancer patients. The results show that a stem cell-like expression profile of t...

Neurotransmitters signal aggressive cancer, offer potential for early diagnosis

...dicine in St. Louis. The researchers investigated metastatic neuroendocrine tumors, which include aggressive ty...fy substances, like GABA, that are associated with metastatic tumors. Usually these tumors are diagnosed only after they have spread to other parts of the body, b...

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