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Tag: "metastasized" at biology news

Dealing deadly cancers a knockout punch

...on of Reolysin in patients with sarcomas that have metastasized to the lung. For patients with deadly soft tissue sarcoma, the lungs are the most common site of metastatic disease. To date, surgery has been the only effective therapy for metastatic sarcoma. The multi-center, Phase II study follows successful c...

A genetic 'gang of 4' drives spread of breast cancer

...e four genes in human breast cancer cells that had metastasized to the lung, and then tested these cells in mice. To silence the four genes, the scientists used a technique called RNA interference, in which RNA molecules are tailored to suppress expression of target genes. "We found that depriving aggressive me...

'Trojan Horse' agent halts bone metastasis in mice

...to grow and may inhibit blood vessel growth to the metastasized tumor, Rosenblum says. "The fact that this form of VEGF targeting works on different cell receptors in blood vessels and in bone cells is a unique finding that could be clinically significant, not only to treating cancer but other bone disorders,"...

Bones hold the key to blood renewal

...porosis, autoimmune arthritis, and cancer that has metastasized to the bone, for instance, the osteoclasts demolish bone faster than it is built up. This study suggests the effects of such an imbalance may reach well beyond the bone. ...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

...to tumors, it cannot "find" tiny cancers that have metastasized and have not yet "recruited" a substantial system of blood vessels to feed them. To counteract that, researchers have fused a nanoshell to an antibody; the idea behindsuch "immunonanoshells" is to have a targeted nanoshell that can find a specific ty...

Disease progression model of pancreatic cancer developed by Penn researchers

... studied cell lines derived from primary tumor and metastasized cells. From this, the researchers established the occurrence of genomic instability in the mouse model. Genomic instability–continuous formation of mutated chromosomes–leads to widespread genetic changes throughout the affected cells. Genomic instabi...

UCLA scientists transform HIV into cancer-seeking missile

... AIDS virus in new clothes enables it to hunt down metastasized melanoma cells in living mice, reports a UCLA AIDS Institute study in the Feb. 13 online edition of Nature Medicine. The scientists added the protein that makes fireflies glow to the virus in order to track its journey from the bloodstream to new tum...

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