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Tag: "metastasis" at biology news

Telling axons where to go - and grow

...as been implicated in biological processes such as metastasis and invasion of cancer, Dr. Bach points out that "�these results indicate that Rnf6 not only plays an important role in coordinating neuronal development but may be also involved in oncogenesis." ...

Minimally Invasive Cancer Treatments Highlighted

...l in patients with small solitary colorectal liver metastasis treated with RFA shows that their survival was ext...enefit many of the 100,000 people who develop bone metastasis in the United States each year. Heating (RFA) or freezing (cryoplasty) the tumor kills the tumor and...

Eleven gene 'signature' reliably predicts cancer prognosis

...an cancers predicts a marked predisposition toward metastasis and a high probability of poor therapy outcome. In an accompanying commentary, Gordon Mills and others write, "such a "magic marker" [will] have a major impact on patient care." TITLE: Microarray analysis identifies a death from cancer signature pre...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...nt can substantially enhance patient survival once metastasis has occurred." To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest layer of the skin...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...nt can substantially enhance patient survival once metastasis has occurred." To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest layer of the skin...

Engineered skin offers clues to melanoma development

...nt can substantially enhance patient survival once metastasis has occurred." To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest layer of the skin...

Physical and functional interaction of key cell growth molecules linked to cancer

... cells. Increased EGFR activity has been linked to metastasis and treatment resistance for aggressive human tumors and, as a result, the EGFR has been identified as an attractive target for cancer therapeutics. However, the precise role of EGFR in cancer cell biology has remained elusive. Recent studies have s...

MIT engineers an anti-cancer smart bomb

...ing them to create new blood vessels and instigate metastasis and other self-survival activities. The next obvious solution would be combining chemotherapy and anti-angiogenesis--dropping the bombs while cutting the supply lines. But combination therapy confronted an inherent engineering problem. "You can't de...

New understanding of cell movement may yield ways to brake cancer's spread

...ation can help develop treatments that halt cancer metastasis and immune disorders like arthritis and asthma. "Previous studies by us and others have identified how a migrating cell 'gets its wheels' and, mechanistically, is able to move. In this study, we have now determined how these wheels become pointed in...

Whole-body MRI Takes Less Than 20 Min To Scan A Patient's Entire Body For Cancer Spread To Bone

...he entire skeleton in patients with suspected bone metastasis (cancer that has spread to the bone from other par...nsitivity and higher specificity in detecting bone metastasis than other methods,?said Joan C. Vilanova, MD, lead researcher for the study. In addition to all it...

Used in a new way, RNA interference permanently silences key breast cancer gene

...alled TWIST that is known to be involved in cancer metastasis was drastically reduced in the STAT3 knockdown cells, thus greatly reducing the ability of these cancer cells to invade normal tissues like the lung. "Somehow STAT3 is controlling TWIST expression, and this is important to know with regards to activa...

Study of genomic DNA leads to new advances in cancer diagnostics

...ions must be aberrant for abnormal cell growth and metastasis to occur. Indeed, Dr. Maniotis and his colleagues found that the extracellular matrix (ECM), or the microenvironment surrounding the cell, influenced whether the cell's chromatin was sensitive or resistant to Alu I. The group also implicated the cell...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

...o recently the idea of targeting cell migration -- metastasis -- has become an alternative strategy that's gained a lot of interest among researchers." If compounds could be found that slowed or halted cancer spread, doctors could gain valuable time in shrinking the primary tumor. "If we had the luxury of time...

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