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Tag: "metastasis" at biology news

Targeting sugar on blood vessels may inhibit cancer growth

...r death and an area where novel therapies to block metastasis are desperately needed, according to first author ...In cancer, angiogenesis sustains growth as well as metastasis of tumors. An important finding was that, not only could we inhibit the growth of tumors in these m...

How to steer a moving cell

...a better understanding of cell migration in cancer metastasis and inflammatory disease. The study will be published the week of May 7-11 in the journal Proceedings of the National Academy of Sciences (PNAS). Extra-cellular messengers called chemokines are families of small proteins secreted by cells that re...

Executable biology -- Computer science sheds light on animal development

...ortant implications in our understanding of cancer metastasis as well as normal development. Traditional biological models give a fairly static picture of cellular processes, and this limits understanding of the details involved. Biologists and computer scientists from the EPFL (Ecole Polytechnique Federale...

Scientists identify pancreatic cancer stem cells

... for the aggressive tumor growth, progression, and metastasis that define this deadly cancer. In the February 1 issue of Cancer Research, the researchers demonstrate that only 100 of these stem cells are needed to produce human pancreatic cancer in half of mice tested. They also found these cells are at least ...

Genes set scene for metastasis

...in this week's Nature, helps to explain how cancer metastasis can occur and highlights targets for therapeutic treatment. Metastasis ?the leading cause of mortality in cancer patients ?entails numerous biological functions that collectively enable cancerous cells from a primary site to disseminate and overtake...

A genetic 'gang of 4' drives spread of breast cancer

...enes for these four proteins and their behavior in metastasis led us to hypothesize that they might be cooperati...east cancer patients as being associated with lung metastasis manipulate blood vessels to give them an advantage both in the primary tumors and in the lung," he s...

Researchers urge monitoring of bone health during chemotherapy

...ts." Although G-CSF had a strong effect on bone metastasis in the experimental mice, early clinical trials in...gating bisphosphonates as a means to prevent tumor metastasis to bone in breast cancer patients. "We used G-CSF as a tool to understand the implications for tu...

Inflammation may play role in metastasis of prostate cancer

...ression of tumors actually plays a key role in the metastasis of prostate cancer. The research, appearing online March 19 in advance of publication in the journal Nature, identifies a mechanism which triggers metastasis, which is the spread of cancer in late stages of prostate cancer development. The findings ...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

...are associated with tumors; and the "M" designates metastasis of the cancer to other organs. The autopsy and other accounts indicate that the cancer was large, lymph nodes were present around the stomach and there were no tumors in other organs. Only 20 percent of patients with Stage IIIA gastric cancer survive...

Protein found to shield pancreatic cancer cells from self-destruction

...sms by which TG2 might promote drug-resistance and metastasis have remained elusive, the researchers note. In th...kB known to play a role in regulating cell growth, metastasis and apoptosis. This pathway, Mehta explained, could make TG2 an attractive target for other forms of...

Math model predicts cancer behavior

...igators have focused on the events of invasion and metastasis (movement of a tumor to distant sites), Quaranta s...r that particular tumor, what are the chances that metastasis is going to occur," Quaranta said. "Does that patient need to be treated very aggressively, or not s...

Antibody extends life of mice with breast cancer

...ic decline in the overall incidence of spontaneous metastasis to the lung -- 88 percent to 47 percent -- and fewer macroscopic metastatic lesions." The research group currently is determining if JAA-F11 could increase the effectiveness of existing cancer drugs, she said, as well as studying the possibil...

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis

...to classify various tumors and assess tumor stage, metastasis and patient survival rates, the evidence suggests that gene-based prediction for lung cancer is not yet entirely dependable. However, some results have been promising: gene profiling has reliably predicted patient survival for lung adenocarcinoma al...

World's smallest cancer detection device

...ovide deeper understanding of the causes of cancer metastasis and migration ? knowledge that is of critical importance in the treatment and, ultimately, prevention of cancer." Dr. Condeelis has used the multiphoton confocal microscope to directly observe cellular interactions in the tumor microenvironment of ...

Speeding discovery of the 'human cancer genome'

...vasive, identifying Nedd9 as a "bona fide melanoma metastasis gene." Nedd9's role appears to result from its interaction with another enzyme known to be important for cell's ability to migrate and take root. As further evidence, they also found that the Nedd9 gene was frequently expressed at higher levels in...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

...chanism that drives cancer movement -- also called metastasis -- can be understood well enough to manipulate it, new and better treatments can be developed for patients with metastatic cancers. Significance of the Mayo Clinic Research The Mayo researchers focused on odd protrusions observable by microscope ...

Researchers identify genes in fruitflies that may shed light on human cancer spread

...le in both border cell migration in fruitflies and metastasis in animal cancer cells; some that had long been suspected to play a role in cell migration, but have been more difficult to study because their functions are shared by other genes; and some that are well understood for their roles in other cellular...

Rewind, please: Nature paper shows that cell division is reversible

...prove important to controlling the development and metastasis of certain cancers. It also holds promise for the prevention and treatment of birth defects and a wide variety of other conditions. "Dr. Gorbsky's results provide elegant proof that the cell cycle must be precisely controlled," said Dr. Rodger McEve...

Tumor cells that border normal tissue are told to leave

...tatic tumor." Having created a model for studying metastasis of tumor cells, the research team has begun to loo...n their fruit fly model. "A drug that can prevent metastasis would be an important adjunct for cancer treatments," Cagan says. "It could cut a patient's risk of ...

New evidence supports century-old theory of cancer spread

...s the German pathologist Otto Aichel proposed that metastasis is caused by cancer cells fusing with macrophages. "There is now evidence to support all aspects of his proposition," said Pawelek. "Macrophages are among the most motile cells we have. By co-opting the macrophage's ability to move, the hybrid is ver...

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