Obese people are more sensitive to pain, suggests study
...ural nerve. When the brain senses pain, it sends a message to the body to contract and move the muscles in order to get away from the source of the pain. "This kind of evaluation is in some ways a more objective way of measuring the body's response to pain, as opposed to simply asking someone if they feel p...Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown
...ks the brain. The protein attacks myelin, disrupts message transfer through the axons and eventually can lead to the brain/mind-destroying plaques and tangles visible years later in the cortex of Alzheimer patients. The Apolipoprotein E (ApoE) genotype is the second most influential Alzheimer risk factor, a...Salmonella bacteria use RNA to assess and adjust magnesium levels
...an says. "But here we're talking about a part of a message that does not encode a protein. So why would it be conserved? There must be some important role that the sequence is fulfilling that is leading to its conservation, such as giving the cell expanded ability to sense and respond to magnesium levels." ...Novel method reveals how menthol discovery could point towards new or improved pain therapies
...al signal that alerts the neuron, which relays the message to the brain. Research Associate Michael Bandell, the lead author of the study, noted, "It's a well established method to mutate individual amino acid residues in an ion channel protein and examine the effect that these mutations have on the channel...Climate change drives widespread amphibian extinctions
...d reduce threats to species extinctions." But the message goes beyond amphibians, says Scheiner: global warming and the accompanying emergence of infectious diseases are a real and immediate threat to biodiversity and a growing challenge for humankind. The decline of amphibians in apparently pristine, prot...Cracking the genetic code for control of gene expression
...ars. But without a code or 'grammar' to reveal the message behind the sequence, the genomic DNA is merely a list of millions and millions of base pairs, A's, C's, G's and T's one after the other. Based on the universal code by which DNA encodes amino acids, we can make sense of the constantly increasing amo...Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
...in memory functions. But how the body delivers the message instructing the brain to step up its formation of new cells is yet unknown. The central nervous system (CNS), comprising the brain and spinal cord, has been considered for a long time as "a forbidden city", in which the immune system is denied entry...Study in Science holds promise for a new approach to drug therapy
...oteins subunits, in effect, pass on the biological message inside the cell sent by the ligand that activates a GPCR on the outside. The free G protein gamma-beta subunit can, for example, "turn on" key target enzymes like phospholipase C and phosphoinositide 3 kinase. In white blood cells, the beta-gamma sub...Bringing the zoos to the zebras
...ng their young. "Clearly the community took this message on board because when we returned a year later they had changed their behavior and allowed Grevy's zebras to walk with the livestock," added Rubenstein, principal investigator of the Earthwatch-supported Grevy's Zebras project. Since 2001, teams of ...Hooked on fishing, and we're heading for the bottom, says scientist
...er, Canada. "We don't need more science. This is a message that's different from many of my colleagues. Of co...ving the prize was one additional push to move his message from the open sea to the political beachhead. But he emphasizes that research alone won't solve the ...Infection 'alarm' yields clues to immune system behavior
... learned how a common protein delivers its warning message to cells when an infectious agent invades the body... or toxin in the body. They produce TNF to carry a message about this health threat to neighboring blood vessel cells, asking them to join in the fight. To sen...Free HIV tests cheaper than charging when goal is preventing AIDS
...Helen Chu. "I think there is an important policy message here," said Thielman, an associate professor of infectious diseases and medicine at Duke University Medical Center. "Providing free HIV tests increases the number of clients presenting for evaluation and makes HIV prevention more cost-effective. We c...Predators keep the world green, ecologists find
...on of top predators such as wolves. "The take-home message is clear: the presence of a viable carnivore guild is fundamental to maintaining biodiversity," the authors wrote. Information collected for the Journal of Ecology report is a five-year update of results published by Terborgh and 10 other scientists...MicroRNA may have fail-safe role in limb development
...or the human body, and RNA, which translates DNA's message into proteins - the building blocks of cells, organs and all of the various systems of the body. Unnoticed next to the main ingredients, microRNAs were considered to be "junk" DNA, leftovers from millions of years of evolution. More recently, this g...Carnegie Mellon U. transforms DNA microarrays with standard Internet communications tool
...the recipient's computer can determine whether the message was accurately received. If not, the recipient's computer asks the sender's computer to forward the message again. Bar-Joseph's method carries out a similar analysis of the microarray snapshots by "checking"...Technique offers new view of dynamic biological landscape
...rotein, reducing its lifespan by mutating the mRNA message lowers the amount of protein the cell can produce. The group called this approach "decreased abundance by mRNA perturbation" (DAmP). "The DAmP technique gave us a way of lowering the abundance of a target gene's messenger RNA while maintaining its ...Research: Snails were overlooked contributors to marsh destruction
...cosystem," Silliman said. "For marsh ecology, the message is even clearer: The long-standing paradigm that bottom-up forces rule is officially dead." Climate change aside, the study also falls in line with other recent studies highlighting the role of predators or other top-down animals. "This study adds t...Johns Hopkins flu expert calls for mandatory vaccination of health care workers
...the editorial, Perl concludes that, "'Shifting the message from self-interest to altruism in protecting patients may improve vaccination rates, but it won't fix the problem. From a hospital policy standpoint, this is a real patient safety issue and vaccination can be viewed as a means of protecting patients...Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer
...gest a receptor-mediated process. "The take home message is that you need to have a targeted entity to kill the cancer cells," Dr. Leuschner says. "Without the LHRH targeting moiety, the nanoparticle-drug construct doesn't kill the cancer cells and it's like a generally systemic chemotherapy drug." Aga......ntiomer composition, "you're actually changing the message signals, and you end up having a signal that is essentially different," Greenwood added. "It's not just a single message." The research team analyzed secretion samples from six male elephants and found that the pheromone is first detectable in the l...