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Tag: "melanoma" at biology news

Researchers unveil strategy for creating actively-programmed anti-cancer molecules

...d the chemically programmed antibody approach in a melanoma model, dramatically enhancing the effectiveness of a small molecule drug (International Journal of Cancer 119 (5), 1194-1207, March 28, 2006). In the new study, the researchers used a self-assembly process to link small synthetic molecules and a we...

Buckyballs boost antibody's chemotherapy payload

...ZME-018 can be used to deliver drugs directly into melanoma tumors, and work at Rice has shown that Taxol can be chemically attached to a buckyball. "The idea that we can potentially carry more than one Taxol per buckyball is exciting, but the real advantage of fullerene immunotherapy over other targeted the...

Speeding discovery of the 'human cancer genome'

...'s group examined genetically engineered mice with melanoma that had developed an increased potential to sprea...ked the protein in both mouse and human metastatic melanoma cells. Cancer cells without active Nedd9 lost their ability to invade. Similarly, primary melanomas,...

Malignant melanoma cells secrete protein required for embryo formation

...sity research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to...le embryonic growth factor by injecting aggressive melanoma cells into developing zebrafish embryos, which were used as "biosensors" for tumor cell-derived sign...

Researchers find molecular 'brake' to cell death

... that quickly become resistant to therapy, such as melanoma and ovarian tumors, do so because they have found ways to prevent mitochondria from releasing a lot of CC, he says. Tumor cells also don't want to decrease their nucleotide pool, because they need ATP for continued functioning, he says. "An optimal ...

Can dogs smell cancer?

...t of a dog alerting its owner to the presence of a melanoma by constantly sniffing the skin lesion. Subsequent studies published in major medical journals confirmed the ability of trained dogs to detect both melanomas and bladder cancers. The new study, led by Michael McCulloch of the Pine Street Foundation...

Melanoma vaccine strategy shows promise in laboratory experiments

A novel approach to creating a vaccine to treat melanoma has demonstrated promising effectiveness in a new ...earchers at The Wistar Institute. About a third of melanoma patients might benefit from such a vaccine. The study appears in the current issue of Cancer Researc...

Canine cancer vaccine program shows early promise

...rease its anti-cancer activity. "Not all dogs with melanoma respond to this treatment," cautions Ilene Kurzman...nventional treatment, 75 percent of dogs with oral melanoma will die within one year. But about 40 percent of dogs with a melanoma tumor present responded to a...

Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs

...ls and is mutated in the majority of patients with melanoma and in a minority of patients with colon, breast, and lung cancers. The findings, available in an advance online publication of Nature, represent a potential targeted therapy tailored for patients whose tumors contain this mutation. The researchers ...

New evidence supports century-old theory of cancer spread

...en they created hybrids in the lab by fusing mouse melanoma cells with mouse macrophages. "Their behavior wa...ls were extraordinarily motile compared to unfused melanoma cells. They spread rapidly when implanted in mice. Even though the idea is virtually unknown to canc...

Model identifies genes that induce normal skin cells to become abnormal

...nteracting with the microenvironment of metastatic melanoma cells induces normal skin cells to become similar ...sional collagen matrix preconditioned by malignant melanoma cells. Hendrix is president and scientific director of the Children's Memorial Research Center, pro...

Stem cell microenvironment reverses malignant melanoma

...ESC) lines (federally approved) induced metastatic melanoma cells to revert to a normal, skin cell-like type w...r to hESCs. The researchers also showed that these melanoma cells were less invasive following culture on the microenvironments of hESCs. "Our observations hig...

Nanoparticles, nanoshells, nanotubes: How tiny specks may provide powerful tools against cancer

..., such as colon, lung, and ovarian, as well as for melanoma and non-Hodgkin's lymphoma. The next step is to...ncreatic, breast, bladder, colon, cervical, brain, melanoma and lung cancers. Since the nanocomplex systemically targets both primary tumors and metastases, ...

Magnetic probe successfully tracks implanted cells in cancer patients

...es to locate therapeutic cells injected into eight melanoma patients. "Our results show that the MRI-based technique was more accurate than tracking the cells using radioactivity and that ultrasound failed to accurately guide injection of the cells into lymph nodes in half of the patients," says Bulte, an a...

Researchers discover why melanoma is so malignant

About 60,000 Americans will be diagnosed with melanoma this year, says the American Cancer Society, and 1... will be fatal. If not caught in the early stages, melanoma can be a particularly virulent form of cancer, spreading through the body with an efficiency that fe...

Vaccine targets tumors where they live

...ned to battle cancer, but their use for metastatic melanoma is a challenge. Effective vaccines against establi...easible to use for local delivery into established melanoma lesions. 2 of the injected lesions showed a partial response and 3 were stable. One patient remained...

Researchers discover how tumor suppressor gene works

...ered how a gene that suppresses the development of melanoma and other human cancers works. The study points th...r Biology. A critical event in the development of melanoma and other human cancers is the inactivation of a gene known as "p16." Normally, p16 keeps cells from...

Newfound roadblock to interferon effectiveness against malignant melanoma

...uting factor to interferon resistance of malignant melanoma cells. The finding represents a step forward in un...ie resistance to established therapies. Malignant melanoma is the deadliest form of skin cancer, and if not treated successfully, it can spread to affect the l...

Researchers use RNAi libraries to identify regulators of apoptosis and chemoresistance

...h multiple genetic alterations are associated with melanoma development, scientists have not been able to esta...ytes. Over the past four decades, the incidence of melanoma has risen 15-fold, a more rapid increase than that of any other cancer. "The only current treatment...

Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

...h multiple genetic alterations are associated with melanoma development, scientists have not been able to esta...ytes. Over the past four decades, the incidence of melanoma has risen 15-fold, a more rapid increase than that of any other cancer. "The only current treatment...

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