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Tag: "melanoma" at biology news

Sun exposure early in life linked to specific skin cancer gene mutation

...). The results indicate that different subtypes of melanoma are associated with different risk factors "The findings suggest that melanoma subtypes have different causes. This is important for learning more about how to prevent and treat s...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

...l carcinoma, squamous cell carcinoma and malignant melanoma - accounted for 27 per cent of all male cancers an...cent more likely than men to suffer from malignant melanoma - the least common, but most serious skin cancer - which averages 186 cases a year. Being well-of...

Researchers publish first marsupial genome sequence

...ability to learn more about the molecular basis of melanoma and its progression, as well as explore development of new therapies and preventive treatments. The opossum genome sequence also provides researchers with a fresh perspective on the evolutionary origins of the human genome. It sheds light on the ...

Dealing deadly cancers a knockout punch

...splatin, a standard chemotherapy agent, in a mouse melanoma model that included both cultured cells and live a...ective than cisplatin or reovirus alone at killing melanoma cancer cells in a mouse model. The investigators intend to explore the mechanism of this promising ...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

...CTLA-4, began to be tested in patients in 1999. In melanoma treatment, between 15 and 20% of clinical objectives have been reached (reduction or disappearance of the tumor), which the researchers see as a positive sign to continue with the research. Currently, the researchers study its benefits in cancer s...

'Guardian of the genome' protein found to underlie skin tanning

...t light from the sun, it deters the development of melanoma skin cancer, the fastest-increasing form of cancer...sk of melanoma. "The number one risk factor for melanoma is an inability to tan; people who tan easily or have dark pigmentation are far less likely to devel...

Study calculates patient time costs associated with cancer care

...21.1 and 20.8 days) and shortest for patients with melanoma (2.2 days), prostate cancer (3.8 days) and breast ...h medical care varied, ranging from 17.8 hours for melanoma to 351.3 hours for gastric cancer and 368.1 hours for ovarian cancer. When the researchers applied t...

A genetic 'gang of 4' drives spread of breast cancer

...in metastasis of other cancers -- such as sarcoma, melanoma and colon cancer -- to the lung, said Massagué....

Molecular differences between early and advanced melanomas could provide new drug targets

...sts introduced the gene for Akt into radial growth melanoma cells, the cells expressed nearly eight times as m... tumors and lead to unregulated cell growth. When melanoma cells overexpressing Akt were introduced into immunocompromised (nude) mice, the mice developed aggr...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

.... In working to identify a key tumor antigen in melanoma and other cancers, scientists at The Wistar Instit...and Immunology programs at Wistar. "Most of the melanoma vaccines currently in development work to activate a type of white blood cell called cytotoxic T-lym...

UCSF brain tumor vaccine trial shows promising results

...e Food and Drug Administration for both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). Reviewing the presentation at AANS, Henry Brem, MD, director of neurosurgery at the Johns Hopkins Medical Institutions, noted, “This is an encouraging study of a therapeutic cancer vaccine t...

Researchers urge monitoring of bone health during chemotherapy

...one tumor growth. When the researchers injected melanoma or breast cancer cells into mice, those getting G-CSF developed a two-fold increase in tumor burden, a measure of the size and severity of tumors, compared to those that did not receive G-CSF. Interestingly, mice treated with a bisphosphonate, an an...

Scientists map key landmarks in human genome

...s derived from several cancer cell lines including melanoma and breast cancer, as well as several normal human cell types. A critical component of the analysis involved processing the data using computational algorithms devised by Dana-Farber faculty member X. Shirley Liu, PhD, and her postdoctoral fellow Jun...

How T lymphocytes attack

...y at the Institute: one in patients with choroidal melanoma and the other in women with cervical cancer. ...

Reversing cancer cells to normal cells

... Hendrix and colleagues discovered that aggressive melanoma cells (but not normal skin cells nor less aggressive melanoma cells) contain specific proteins similar to those found in embryonic stem cells. This groundbreakin...

Why don't all moles progress to melanoma?

...65 Americans born this year will be diagnosed with melanoma at some point during their lifetime. Scientists know that 30 percent of all melanomas begin in a mole. They know that 90 percent of moles contain cancer-causing mutations. What scientists didn't know is how melanocytes stop these mutations from tri...

Science researchers genetically transform immune cells into tumor fighters

...s in humans. Two of the 17 people with advanced melanoma who received the experimental treatment saw their ... therapy has only been used in this small group of melanoma patients, but Rosenberg says his team has demonstrated ways to engineer similar immune cells in the ...

Who gives stem cells their marching orders?

...ity seems to confirm this, showing that aggressive melanoma cells secrete the Nodal protein. Understanding the activity of this gene in embryonic development may hold the key to finding a way to control its activity in tumor cells. "We need to separate the aspects of Nodal function, and how this protein is re...

Vaccine for brain tumors shows promising results

...he Food and Drug Administration in both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). The UCSF clinical trial is a phase1/2 study designed to establish the feasibility, safety and preliminary efficacy of vaccination in patients with recurrent, high-grade glioma. The trial inv...

Scientists tie several cancers to common 'oncogene engine'

...d that the MITF gene is amplified in 20 percent of melanoma tumors. In addition, Fisher and Scott R. Granter, MD, of Children's Hospital Boston ?also an author of the Cancer Cell article ?previously found that MITF was present in a dangerous type of soft-tissue tumor ?clear cell sarcoma ?that develops near m...

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