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Tag: "mediates" at biology news

How A Latent Virus Eludes Immune Defenses

...erestingly, the MHV-68 episome maintenance protein mediates immune evasion even though it lacks the amino acid element that does the job for EBV. Future studies will have to determine the responsible MHV-68 epitope and the mechanisms that engineer immune avoidance. Since a majority of epitopes that killer T c...

Touching Molecules With Your Bare Hands

...erestingly, the MHV-68 episome maintenance protein mediates immune evasion even though it lacks the amino acid element that does the job for EBV. Future studies will have to determine the responsible MHV-68 epitope and the mechanisms that engineer immune avoidance. Since a majority of epitopes that killer T c...

Evolution of taste receptor may have shaped human sensitivity to toxic compounds

...a human gene encoding a bitter-taste receptor that mediates recognition of a class of naturally ubiquitous, but toxic, cyanide-releasing compounds. By analyzing sequences from a large sample of individuals representing 60 human populations, the researchers found evidence that specific variants of the receptor...

Attacks of King George III's madness linked to key metabolism molecule

PGC-1 mediates effects of nutrition on blood disease porphyria Dana-Farber Cancer Institute researchers say they have uncovered a molecular explanation for the episodic attacks of irrational and demented behavior in porphyria, the disease believed to have afflicte...

Energy management in cells may hold key to cancer defense

...also responds to changes in insulin or glucose and mediates impaired energy metabolism, a hallmark of type 2 diabetes. "This indicates that AMPK is a very tempting target for the treatment of some forms of diabetes and even obesity," said Witters. As Witters' laboratory continues to zero in on the central r...

Protein structure key for AIDS, cell function

...ittle. "For example, the mechanism of how a cell mediates calcium release is largely unknown," said the paper's senior author, Quan Hao, director of the Macromolecular Diffraction Facility (MacCHESS), the biomedical research arm of the Cornell High Energy Synchrotron Source (CHESS). "So this is a very funda...

Gradient guides nerve growth down spinal cord

...nts through a different receptor, called Ryk, that mediates repulsion by Wnts. Antibodies that blocked the Wnt-Ryk interaction blocked the downward growth of corticospinal axons when injected into the space between the dura and spinal cord in newborn mice. This knowledge, coupled with emerging stem cell tech...

Gene that helps mosquitoes fight off malaria parasite identified

...a to humans. "An immune-responsive serpin, SRPN6, mediates mosquito defense against malaria parasites" was written by Eappen G. Abraham, Sofia Pinto, Anil Ghosh, Dana L. Vanlandingham, Aidan Budd, Stephen Higgs, Fotis C. Kafatos, Marcelo Jacobs-Lorena and Kristin Michel. Abraham, Ghosh and Jacobs-Lorena are ...

Wolves' top-down effect

...e compelling finding of the paper, "Human Activity mediates a Trophic Cascade caused by Wolves" that appears i...rge predators," says Hebblewhite. "Human Activity mediates a Trophic Cascade caused by Wolves," Ecology 86 (8), August 2005 ...

Algal protein in worm neurons allows remote control of behavior by light

...at lacked the C. elegans ion channel that normally mediates backing behavior in response to touch. The researchers performed electrophysiological experiments to show that the effects they observed were indeed due to the inward flow of ions caused by activation of the ChR2 protein by light; this inward ion fl...

Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects

nterferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis. "Essentially, we found a way ...

Sea slug mixes chemical defense before firing at predators

...ous research, Derby's team determined that escapin mediates the chemical reaction with L-lysine and L-arginine that results in the defensive secretion. Using a variety of chemical and molecular techniques, the scientists identified L-lysine and L-arginine in the opaline gland, which produces the sticky white ...

New technique helps researchers determine amino-acid charge

...ic acetylcholine receptor, a membrane protein that mediates voluntary muscle contraction. "Our paper has implications that are specific to this receptor, but many of the findings can be extended to several other membrane proteins," said Claudio Grosman, a professor of molecular and integrative physiology at ...

Common bacteria pirate natural mechanism to get inside cells

...protein inside the cell to the active protein that mediates the fission of the vesicle inside the cell." Apparently, bacteria and viruses can increase nitric oxide levels to make this normally protective system work for them as well. Identifying this role of nitric oxide provides a new target for finding be...

Mice lacking social memory molecule take bullying in stride

...ain (ventral tegmental area), the relevant circuit mediates responses to emotionally important environmental stimuli via release of dopamine. Activity of this neurotransmitter is regulated in the circuit by brain derived neurotrophic factor (BDNF), which is known to play a key role in memory ( http://www.nim...

Protein found to control tumor growth in certain breast cancers

...ptor in vitro, further indication that the protein mediates the sensitivity of hormone-dependent breast cancer cells to tumorigenesis. "While still preliminary, our data adds another critical function to Nod1," Ulevitch said, "namely its ability to regulate the growth of estrogen-sensitive tumors formed by s...

Traditional Chinese medicine for diabetes has scientific backing

...nvestigate how berberine activates the enzyme that mediates these 'insulin-sensitising'effects. ...

Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience

...ybin act upon," Schuster says. "Understanding what mediates these effects is clearly within the realm of neuroscience and deserves investigation." "A vast gap exists between what we know of these drugs-mostly from descriptive anthropology-and what we believe we can understand using modern clinical pharmacol...

Meth promotes spread of virus in HIV-infected users

...e next question we want to answer. "Since meth mediates its effects through interacting with dopamine receptors present on the cells, and meth increases DC-SIGN, which are the HIV attachment receptors, use of dopamine receptor blockers during HIV infection in meth users could be beneficial therapeuticall...

Stomach receptor for H. pylori discovered

...es in infected mice, suggesting that this receptor mediates H. pylori-induced injury in the stomach." These findings suggest that drugs that interfere with DAF binding could be used to prevent or treat peptic ulcer disease or distal gastric adenocarcinoma. These new drugs will be a welcome alternative to the...

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