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Tag: "mediated" at biology news

A new mechanism of regulating RNA degradation

...egulated by cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip of the iceberg" for Staufen1's function in mammalian ce...

FDA Approves Human Hookworm Vaccine for Phase I Safety Trials

...egulated by cell signaling pathways, such as those mediated by changes in growth conditions." That would allow the cell to differentially control the level of SMD-target RNAs, while leaving the NMD-regulated RNAs untouched. This is likely to be the "tip of the iceberg" for Staufen1's function in mammalian ce...

U of M researcher examines newly emerging deadly disease

...curs. In addition, because toxic shock syndrome is mediated by superantigens, it is possible that intravenous immunoglobulin therapy may be indicated. Of the five patients observed in the Minneapolis-St. Paul area during the period of 2000-2004, four of the patients were previously healthy and four of the pat...

Yale researchers identify molecule for detecting parasitic infection in humans

...nition of T. gondii by the innate immune system is mediated by a new member of the TLR family, TLR 11, that we discovered last year," said Sankar Ghosh, professor of immunobiology at Yale School of Medicine. "We further found that the specific recognition molecule was Toxoplasma profilin. The innate immune sy...

Stopping smallpox in its tracks: A new anti-viral approach

...apy ?a low molecular weight inhibitor of signaling mediated by the smallpox growth factor (SPGF). SPGF targets the erbB-1 signaling molecule, which normally initiates an intracellular cascade that facilitates viral replication. This study shows that drugs that interfere with erbB-1 signaling inhibit SPGF-in...

Key mechanism in genetic inheritance during cell division identified

...at binding between the ring and the microtubule is mediated by flexible domains, and is largely electrostatic in nature. This could allow for lateral sliding or diffusion of Dam1 rings along microtubules. Analysis of the Dam1 rings after disassembly of microtubules, revealed an accumulation of rings at the en...

Researchers develop assay that could be applied to drug screening

...rtant routes for cargo internalization is clathrin mediated endocytosis (CME). CME is of fundamental importanc...merization. "The role played by actin in clathrin mediated endocytosis has been controversial for a long time," Zenisek said. "We've now shown in live cells th...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...atented Red/ET Recombination, also known as lambda mediated cloning, enables cloning and precise manipulation and modification of DNA molecules regardless of restriction sites and is particularly useful for the rapid generation of targeting vectors, modification of BACs and E. coli chromosomes, as well as vir...

When in danger humans are similar to a deer in the headlights

... species when confronted with threatening stimuli, mediated by neural circuits that promote defensive survival," author Eliane Volchan explains. This study is published in the current issue of Psychophysiology. Media wishing to receive a PDF of the full article please contact journalnews@bos.blackwellpublish...

Stem cells bring fast direct improvement, without differentiation, in acute renal failure

...IGF-1, all known to improve renal function in ARF, mediated by their antiapoptotic, mitogenic and other cytokine actions," the paper said. "Specifically, these as yet incompletely defined paracrine actions of MSC result in the renal downregulation of proinflammatory cytokines IL-1-beta, TNF-alpha, and IFN-ga...

Studies on human genome variation provide insight into disease

...lves a deletion on chromosome 22. The deletion is mediated by rare repetitive sequences that flank genes crucial for proper development of the heart, face, and upper thorax. Dr. Bernice Morrow and her colleagues describe in this month's issue of Genome Research how they examined these flanking repetitive ...

Housecat-sized Siberian tiger cubs get collared

...lves a deletion on chromosome 22. The deletion is mediated by rare repetitive sequences that flank genes crucial for proper development of the heart, face, and upper thorax. Dr. Bernice Morrow and her colleagues describe in this month's issue of Genome Research how they examined these flanking repetitive ...

Plant gene related to cancer treatment may foster new oncology drugs

... that both the uptake and release of molecules are mediated by interaction between the PGP transporter proteins and PIN facilitator proteins," Murphy said. ...

Membrane research opens window to benefits for plants, humans

...e two types of closing events, both mechanisms are mediated through the same structural elements of the protein -- that is by plugging the cytoplasmic entrance of the channel with an eolongated intracellular loop." By atomic scale, the structural difference between open and closed channels is telling. When ...

Synthetic Protein Eases Arthritis Symptoms in Mice

... both TNFRs and thereby inhibit beneficial actions mediated by TNFR-2. The scientists next aim to develop a more stable form of P60 PLAD. Ultimately, they hope to test the protein in clinical trials. The research was also supported by the National Institute of General Medical Sciences, part of the NIH. ...

Have a taste for fat? Yes! A sensor in the mouth promotes preference for fatty foods

...at and the changes in gastrointenstinal secretions mediated by oral delivery of lipids. These findings unveil one potential pathway mediating fat taste. The data suggest that an alteration in the fat perception system might increase obesity risk through feeding dysregulation. In an accompanying commentary...

UCSD study finds anthrax toxins also harmful to fruit flies

...similar mechanistically to wound healing, which is mediated by the same signaling pathway in humans. The EF toxin is also lethal when applied to fly larvae and can cause severe malformation in the wings of adult fruit flies--an effect that can also be understood as an interruption of another unrelated signal...

Common bacteria pirate natural mechanism to get inside cells

...ystem," says Dr. Daaka. "We think their hiding is mediated through dynamin. This is not only applicable to this particular pathogen but for many more." Dr. Daaka, who studies receptor signaling, likens receptors to television antennae that control relay of signals from outside the cell to inside by turning ...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

...glycoforms showed significantly increased antibody mediated cell killing compared to Rituxan®. "By controlling the sugar structures on antibodies we have shown that the antibodies ability to kill cancer cells can be significantly improved and that therapeutic proteins can be optimized by controlling their su...

Darkness unveils vital metabolic fuel switch between sugar and fat

...time delays pointed to the gene's expression being mediated by something in the blood. Another lab test showed elevated levels of 5'-AMP in the blood of mice exposed to constant darkness compared to those kept in the regular light-dark cycle. To confirm the connection, the team injected 5'-AMP into mice exp...

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