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Tag: "mechanistic" at biology news

Neuronal 'traffic jam' marks early Alzheimer's disease

...said Goldstein. "This makes it clear there is some mechanistic connection between the transport deficit and plaque deposition. "So, our hypothesis is that in familial Alzheimer's disease -- or in disorders such as Down syndrome where beta-APP is overexpressed -- those defects cause early failure in cellular tra...

Needling Chromosomes Reveals Cell Division Secret

...odscience since we raise new questions. We lay the mechanistic groundworkfor the molecular explanations that have to be made. So, our colleagueswho do molecular work are both provoked and challenged by us," he said....

Effective Cancer Treatments Follow The Clock

...tivity to CY. “Thus, this paper gives us specific mechanistic insight into the role of circadian rhythms in sensitivity to such drugs,?said Takahashi. “This is not some vague metabolic difference between day and night. This is a tangible difference in the immune system that influences sensitivity.?/p> The f...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...f skin cancer progression than skin development, a mechanistic understanding of hair follicle development promises to shed light on how skin cancer develops as well. ...

Unraveling a stomach cancer puzzle

...F beta, and this allows cancer formation, and this mechanistic link is a world-first. Also, the gene differences identified in human stomach cancers are similar to those we would predict if the same thing, Stat3 hyperactivity shutting down TGF, happens in humans. So this is also the first time a connection betwe...

Scientists track stealth DNA elements in primate evolution

...tist Dr. Mark A. Batzer, provides the first strong mechanistic evidence for the evolution of Alu elements to date. It appears in the May issue of the journal Genome Research. Alu elements are short, 300-nucleotide-long DNA sequences capable of copying themselves, mobilizing through an RNA intermediate, and inse...

New understanding of jet lag

...for jet lag. This is the first time that we have a mechanistic understanding of the systematic coupling of the different parts of the clock. We are now on our way to suggesting strategies for shifting the clock more quickly in response to unnatural light cycle changes." Block said that future therapies, using t...

Genetic variation alters response to common anti-clotting drug

...s complete genetic analysis of VKORC1 provides the mechanistic framework and impetus for prospective studies in a clinical setting. Such studies could determine if knowledge of genetic variability truly improves patient treatment with this frontline anticoagulant drug." ...

UW-Madison scientists zero in on drugs' sweet spots

...chnique) is going to send us down some interesting mechanistic roads," Thorson notes. "Digitalis hasn't been aggressively pursued as an anti-cancer agent." According to Thorson, the technology can be widely applied: "We've already taken this chemistry and applied it to many different drug classes. It's possible...

A bug's life: Exceptional genomic stability yet rapid protein evolution in a carpenter ant mutualist

...ntists are currently uncovering the biological and mechanistic basis for these mutualistic associations. One of the primary genomic characteristics of obligate bacterial symbionts is a massive reduction in genome size compared to their free-living counterparts ?a phenomenon called "genome streamlining." Addition...

Max Planck researchers make a breakthrough in plant stem cell research

...reby identified four genes, which might serve as a mechanistic connection between plant hormones and the genetic regulatory elements in meristem. The researchers in Tübingen used gene expression analysis to show that the genes ARR5, ARR6, ARR7 and ARR 15, "Arabidopsis Response Regulators", are subject to genet...

Diverse tropical forests defy metabolic ecology models

... Muller-Landau and Condit are currently working on mechanistic models that attempt to better capture these complexities, and thereby attain a better understanding of what factors drive tropical forest structure and dynamics. Achieving such an understanding is particularly critical today, as tropical forests are ...

Macrophage signaling may affect hormone resistance in prostate tumors

...ance.Using cell biology methods, they discovered a mechanistic explanation for at least one form of resistance to...antagonists," said Rose. The research shows at a mechanistic level that the physical interaction of macrophages with prostate tumor cells activates processes in ...

Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure

...ded. "Bursac and Tung have presented a convincing mechanistic explanation for a clinically important phenomenon that they reproduced in a Petri dish," Igor Efimov and Crystal Ripplinger, both of Washington University in St. Louis, wrote in an editorial. "Their study showed that, as in clinical therapy, anti-tac...

Is the brain wired for faces?

...cessing, brain imaging and behavior, we now have a mechanistic model describing which neurons are involved and how they are behaving when we look at faces." Other authors on the paper include Xiong Jiang, PhD, Ezra Rosen, John VanMeter, PhD, and Tom Zeffiro, PhD, from Georgetown University Medical Center and Vo...

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...m Institute for Medical Research have discovered a mechanistic link between cellular stress caused by free radicals and accumulation of misfolded proteins that lead to nerve cell injury and death in neurodegenerative disorders such as Alzheimer's and Parkinson's Disease. That link is Protein Disulphide Isomer...

DOE JGI sequences, releases genome of symbiotic tree fungus

... climate change research and a step further toward mechanistic modeling of ecosystem responses," Rubin said. ...

Researchers uncover new mechanism of tumor suppressor

...ne repression. "Our findings have established the mechanistic principles by which the inhibitor of growth 2 tumor suppressor recognizes chromatin and regulates cell growth, proliferation, stress responses and aging. We hope this discovery opens up new opportunities to establish novel targets to prevent and trea...

Protein connections: A network to understand disease

...is for medical treatment. "Now we are providing a mechanistic basis for understanding why we treat symptoms," she said. In the future, treatments may be designed to interrupt the cellular missteps that lead to disease. Others who participated in this research include: Drs. Chad Shaw, Akash J. Patel and Josep...

Molecular DNA switch found to be the same for all life

... study suggests that there are likely to be strong mechanistic commonalities in the ways that initiators engage and remodel replication origins, as well as in how they facilitate replisome assembly." The idea that all three domains of life share the same DNA replication initiator is new and will require some ...

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