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Mayo Clinic Researchers Create 'Obedient Virus'; First Step To Use Measles Virus Against Cancer

An international team of Mayo Clinic-led researchers is first to devise a system that consistently converts the measles virus into a therapeutic killer that hunts down and destroys cancer cells -- and cancer cells only. Their research findings appear as an advanced electronic article of Nature Biotechnology. .. The researchers harnessed the viral trait for attacking and commandeering cells, and t...

Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot

Mayo Clinic researchers have found that the cause of chronic sinus infections lies in the nasal mucus -- the snot -- not in the nasal and sinus tissue targeted by standard treatment. The findings will be published in the August issue of Journal of Allergy and Clinical Immunology and . "This strikingly teaches against what has been thought worldwide about the origin of chronic sinus infection: th...

Mayo Clinic collaboration discovers protein amplifies DNA injury signals

A Mayo Clinic-led research collaboration has discovered that the protein MDC1 amplifies weak DNA injury signals so genetic repair can begin. Once amplified, even low-level damage signals become strong enough to activate the cell's natural repair processes while the injury is most tractable to repair. . http://www.molecule.org/). The research was conducted in collaboration with colleagues from Ha...

Mayo Clinic researchers challenge sepsis theory

A Mayo Clinic research team has challenged the accepted theory on the cause of sepsis -- a condition in which the body's cells generate fever, shock and often death. Sepsis is thought to occur when poisons from bacterial infection interfere with the cells. . . Their findings suggest that sepsis begins with a change in certain...

Mayo Clinic researchers discover cancer cells may move via wave stimulation

Mayo Clinic researchers have uncovered a new cellular secret that may explain how certain cancers move and spread -- a feature of cancers that makes treatment especially difficult. If the mechanism that drives cancer movement -- also called metastasis -- can be understood well enough to manipulate it, new and better treatments can be developed for patients with metastatic cancers. . .. The Mayo r...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

Mayo Clinic researchers report that the expression of two novel genes within the tumors of women with early stage breast cancer may allow identification of women who are and are not at risk for early relapse or cancer-related death. Results of the study are published in the April 1 issue of Clinical Cancer Research. . "The HOXB13 and IL17BR gene profile was previously discovered as a potential m...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

Mayo Clinic Cancer Center has opened a new clinical study using a vaccine strain of the measles virus to attack recurrent glioblastoma multiforme, a largely untreatable brain tumor. This is the second of several pending molecular medicine studies in patients using measles to kill cancer. . "We are looking at better ways to treat some of the most lethal cancers," says Eva Galanis, M.D., oncologis...

Mayo Clinic collaboration mining of ancient herbal text leads to potential new anti-bacterial drug

A unique Mayo Clinic collaboration has revived the healing wisdom of Pacific Island cultures by testing a therapeutic plant extract described in a 17th century Dutch herbal text for its anti-bacterial properties. Early results show that extracts from the Atun tree effectively control bacteria that can cause diarrhea, as claimed by naturalist Georg Eberhard Rumpf, circa 1650. He documented his tra...

Mayo Clinic study suggests that a central nervous system viral infection can lead to memory deficits

In one of the first known laboratory studies that explores memory deficits associated with a viral infection of the central nervous system, Mayo Clinic researchers have evidence that this infection can lead to memory loss late in life. The study, which was conducted in animal models, suggests that over the lifetime of an individual, a picornavirus-related infection could possibly have a permanent...

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis

While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung cancer patients. . The interest in and the knowledge of gene expression profiling in medical science h...

Mayo discovers protein as potential tactic to prevent tumors

Mayo Clinic researchers have found that a protein that initiates a "quality control check" during cell division also directs cell death for those cells damaged during duplication. This knowledge represents a potential "bulls eye" for targeting anti-tumor drugs. The findings appear in the current issue of Science. . The researchers examined a protein called cyclin-dependent kinase 2 (CDK2), which...

Mayo researchers discover HIV dependence on a human protein

Mayo Clinic virologists have discovered that a specific human protein is essential for HIV to integrate into the human genome. Their findings show that when HIV inserts itself into a chromosome, a key step that enables it to establish a "safe haven," it requires a specific protein -- LEDGF/p75 (p75). This protein forms a molecular tether between chromosomes and HIV's integrating protein (integras...
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