A bacterial genome reveals new targets to combat infectious disease
...us, understanding the details of this relationship may help identify new strategies for controlling disea...arrying iron component of hemoglobin. The nematode may require heme for synthesis of developmental hormones, so Wolbachia's heme pathway may be an inviting...Spider Venom Could Yield Eco-Friendly Insecticides
...ins do not affect the mammalian nervous system, it may be possible to use them to create environmentally ...kinds of venom and uncover insecticide leads, they may be able to target insects that transmit new and emerging human diseases, such as Lyme disease and Ro...New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
...nity to switch patients early on to a therapy that may be more effective. Results of the study appear th...r did not respond to the treatment, a new approach may be tried. Using diffusion MRI and the functional diffusion map, the U-M researchers were able to pr...Gene variations explain drug dose required to control seizures
...oth anti-epileptic drugs tested, the SCN1A variant may be of particular importance for understanding pati...rove dosing decisions, he added. In particular, it may be clinically relevant to determine whether physicians can safely increase drug doses more rapidly f...Solution to Pollution: New Bacteria Eats Toxic Waste
... tells us a lot about the history of the world and may even help us with its future,?said Joanne Hughes, ...e the PAHs and survive in the soil. Such knowledge may help researchers better understand and utilize the organisms to destroy PAH contaminants in the envi...Scientists collaborate to assess health of global environment
...he global view gives averages, and global averages may be misleading," he said, noting that different ecosystems face different issues--overfishing in the Caribbean, for example, versus groundwater usage in Chile's Atacama Desert or wood fuel harvesting in Zambia. Overall, the diminishing capacity of se...Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
...ne therapy methods that specifically target muscle may reverse the symptoms of a rare form of muscular dy... approach of targeting corrective genes to muscles may have application in treating other muscular dystrophies. Patients with Pompe disease have a defect ...Enzyme shown to help protect genomic stability
... other DNA segments. In the telomeres, such events may accelerate aging or trigger cancer in humans." "We have identified a molecular mechanism to explain how this enzyme helps keep telomeric DNA silenced and potentially protects the genome from destabilizing activity," says N.C. Tolga Emre, a graduate ...BRCA1 causes ovarian cancer through indirect, biochemical route
...cer is the result of some biochemical problem that may be correctable or preventable. That's what makes this finding so exciting." Dubeau points out that women with BRCA1 mutations are also predisposed to cancers of the fallopian tubes, and that the mice with mutated BRCA1 genes in their granulosa cells...Scientists decipher genome of fungus that can cause life-threatening infections
...posons (moveable elements)within the genome, which may account for the genome rearrangementsoften observed between different Cryptococcus isolates.TIGR's Fraser says the Cryptococcus genome sequence will benefit a widerange of biomedical research into the increasingly significant humanpathogen. Stanford'...Needling Chromosomes Reveals Cell Division Secret
...the cell. Nicklasbelieves that the twin chromatids may still have some entanglementsbetween the corresponding DNA strands on each chromatid. DNA, whichmakes up genes in the cell, replicates itself as a central process inchromosome duplication."So, we’re left with the mystery of what molecules hold the ch...Poplar trees redirect resources in response to simulated attack
...at compounds are formed." Ferrieri believes there may be an increase in compounds that resist microbial attack after plants have soaked up atmospheric carbon dioxide, therefore countering the effects of fossil-fuel combustion. This is a strategy of carbon sequestration -- the provision of long-term stor...Scientists discover the cellular roots of graying hair
...cells shortlyafter birth and quickly went gray. It may be that people who grayprematurely have mutations that knock out Bcl2 activity, Fisher says.“This tells us there is a requirement for Bcl2 in normal hair folliclecycling,?adds Fisher. “So the question is: what in the hair follicleis signaling the ste...Researchers identify target for cancer drugs
... discovered a missing puzzle piece, a finding that may present drug makers with a significant new cancer ...le that can block the mTOR/rictor complex, then we may be able to prevent Akt from becoming active and contributing to tumor formation." ...Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
...cells shortlyafter birth and quickly went gray. It may be that people who grayprematurely have mutations that knock out Bcl2 activity, Fisher says.“This tells us there is a requirement for Bcl2 in normal hair folliclecycling,?adds Fisher. “So the question is: what in the hair follicleis signaling the ste......cells shortlyafter birth and quickly went gray. It may be that people who grayprematurely have mutations that knock out Bcl2 activity, Fisher says.“This tells us there is a requirement for Bcl2 in normal hair folliclecycling,?adds Fisher. “So the question is: what in the hair follicleis signaling the ste...Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
...tags, and various proteins that interact with them may one day be useful for understanding, diagnosing, and even developing new treatments for some cancers." ...New research questions basic tenet of neuron function
...nctional differences of these two sets of vesicles may be the result of differences in the protein and/or...ions, as their findings suggest, those differences may make it possible to independently regulate spontaneous and activity-dependent neurotransmitter relea...Vital step in cellular migration described by UCSD medical researchers
... used by alpha4 integrins to localize Rac activity may participate in a wide variety of cell migratory and pathfinding events. In addition to Nishiya and Ginsberg, additional authors were William B. Kiosses, Ph.D., The Scripps Research Institute, La Jolla, California; and Jaewon Han, Ph.D., UCSD Departm...U-M scientists find genes that control growth of common skin cancer
... to normal hair follicle stem cells from whichthey may arise.If the results of this study are applicable ...coveryof residual tumor cells and tumor recurrence may be particularlyimportant given the current efforts to develop Hh pathway inhibitors asa means of com...