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Tag: "mature" at biology news

Fox Chase Cancer Center scientists identify immune-system mutation

...scure. "The mutant HD mice are unable to generate mature helper T cells, even though their immature T cells carry the CD4 protein," Kappes explained. "Instead, the mutation redirects them to the killer-cell pathway. "Our new study identifies this defect as a point mutation in the zinc finger transcription...

Researchers Uncover Key Step In Manufacture of Memory Protein

.... The protein is known as mBDNF, which stands for mature brain-derived neurotrophic factor. In an earlier study, another team of NICHD researchers had shown that mBDNF is essential for the formation of long-term memory, the ability to remember things for longer than a day. “Understanding how BDNF is made ...

Genome-wide mouse study yields link to human leukemia

...id of defective cells before they have a chance to mature and divide. When tumor suppressor genes lose that ability ?as they can if they are silenced through methylation or some other process, it gives cancer a chance to establish a foothold and spread. Caligiuri says much more work needs to be done, but a...

Researchers reveal the infectious impact of salmon farms on wild salmon

...omes a moving cloud of contagions. Sea lice larvae mature and reproduce on the seaward salmon with each louse producing 300-800 eggs. This second round of lice larvae can re-infect the fish in the school and can spread to other previously unexposed populations coming from geographically disparate regions. ...

Enzyme allows B cells to resist death, leading to leukemia

...is characterized by theprogressive accumulation of mature B lymphocytes in the blood, bonemarrow, and lymphatic tissues. It is believed that in the early stagesof disease, B-CLL is the result of an undefined defect in theprogrammed signals that trigger normal B cell death (apoptosis). LivioTrentin and colle...

First real-time view of developing neurons reveals surprises, say Stanford researchers

...While the research showed neurons firing in a more mature way than expected, it also revealed that neurons t... time, the network of branches stabilized into the mature form. "We're looking at a dynamic process that nobody has ever seen before," Smith said. Understan...

Scientists identify new model Of NK cell development

...ntrast, B cells, which make antibodies, remain and mature in the bone marrow. Until now, scientists thought NK cells did the same. But Caligiuri, working with Aharon Freud, the lead author of the study and a doctoral candidate in Caligiuri's laboratory, had noted other work showing that mice lacking lymph ...

UCSD team discovers specialized, rare heart stem cells in newborns

...he cells are capable of differentiation into fully mature heart tissue. Called isl1+ cells, these cardiac p...more, the cardiac muscle cells formed were totally mature and had the complete array of function that one would expect in completely differentiated heart tiss...

Children's taste sensitivity and food choices influenced by taste gene

...egetable consumption that often occurs as children mature into adulthood. This is definitely an area that merits more research." The bitter receptor genotype also predicted children's sweet preference, along with their preference for sweet-tasting beverages and foods. Children with a bitter-sensitive allel...

LUCA technologies confirms real-time methane generation

...years ago, when the hydrocarbon deposits were less mature and closer to the surface of the earth. Luca scientists, employing the tools of modern biotechnology and genomics, have now shown that living methane generating, microbial consortia are present and actively forming methane within some of these hydro...

Hirsute Or Hairless? Two Proteins May Spell The Difference

...mal papilla, and both structures contribute to the mature hair follicle. During development, cells are constantly bombarded with external signals. The trick is figuring out which signals trigger the transcriptional and behavioral properties in cells that spur bud formation. In previous experiments, Fuchs a...

Programmable cells: Engineer turns bacteria into living computers

...o patterns that become the various body parts of a mature organism. In fruit fly embryos, for example, the first cells are thought to differentiate into the head, abdomen and other parts based on the concentration of chemical signals that are emitted from the ends of the embryo. In addition to conducting l...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

...s these blood cells develop, the gene protects the mature cell against HIV infection. The UCLA AIDS Institute already has completed a Phase I clinical trial using adult stem cells. Embryonic stem cells also could be engineered for this strategy to avoid the need for isolating patients' cells, ease transplan...

Stem cells from brain transformed to produce insulin at Stanford

...quence that they knew might prod the stem cells to mature into insulin-producing cells. After some trial and error, they found the right combination and sequence. The end result was a dish full of cells that could produce insulin and release it in response to sugar added to the environment. These cells don...

Multi-purpose protein regulates new protein synthesis and immune cell development

...d immune cells in the transplanted mice, but their mature B lymphocytes were defective. Without IRE1, lymphocytes don't develop a B cell receptor and don't have the right rearrangements of immunoglobulin genes to function properly. "Our findings show that IRE1 is required for both the early and late stages...

New insight into regulation of blood stem cells

...sible to study the role of the gene of interest in mature animals. Dr. Michael P. Cooke and colleagues from the Genomics Institute of the Novartis Research Foundation in San Diego found a way around this problem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defec...

Solutions that reduce death of marine life reeled in by International Smart Gear Competition

... metal grids and net meshes that catches and sorts mature shrimp and finfish while allowing juvenile shrimp and fish to swim away unharmed. Sorting mature shrimp and finfish between the lower and upper parts of the net helps to reduce the time the trawler...

Infants With Rare Genetic Disease Saved by Cord Blood Stem Cells

...cal procedure. Finally, cord blood cells are less mature than adult bone marrow cells and thus do not need to perfectly match the patient's immune-related blood proteins, called antigens, said Kurtzberg. Only four of six cord blood "antigens" must match for a transplant to have a reasonable chance of succe...

Genetic defects give the immune system the green light to attack the pancreas

...hymus gland, T-cells begin as “precursor?cells and mature ?during this time, receptor sites on their outer membrane are shaped to dock with each invader and destroy it. “As T-cells form, it is not uncommon for a few to randomly develop with the potential ability to attack the body’s own cells,?said Dr. Hol...

Technique may allow cancer patients to freeze eggs, preserving fertility before starting treatment

...vitrified. For egg freezing to work, it must be a mature oocyte, which means a woman must have 14 days of hormone treatments to stimulate mature egg production. This could limit its applications for some women. Researchers question if it is appr...

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