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Tag: "master" at biology news

Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state

...control of a gene called Oct4 considered to be the master regulator of the stem cell state. A comprehensive ...enes whose expression was also correlated with the master stem cell regulator gene Oct4. They also applied very rigorous analysis methods, using data from Ste...

Master regulatory gene of epithelial stem cells identified

...uding breast, prostate, and urogenital tract. This master regulator of epithelial stem cells turns out to be...ntial for these epithelial stem cells, while other master regulators have been identified for blood stem cells and spermatocyte stem cells, suggests a fundame...

Dinosaur hearing, listening to muscle noise, quieter cubicles

...udents to improve their singing. California-based master voice instructor Lisa Popeil ( lisa@popeil.com ) will explain how a singer can hear and produce three important frequency bands of harmonics: ring (2500-3500 Hz), which helps singers to project their voices in an unamplified setting; brightness (5-15...

Major gene study uncovers secrets of leukemia

...ency of mutations involving genes that function as master regulators of normal B-cell development and differentiation. A report on this work appears in the March 7 online edition of "Nature." "The results of our study demonstrate that it is possible to significantly speed the identification of the g...

New player in commitment to life as a fat cell

...-gamma a transcription factor considered to be the master regulator of fat production since it is both necessary and sufficient for adipose differentiation both in vitro and in vivo, the researchers said. Treatments that inhibited XOR activity in cells blocked fat formation and PPAR-gamma activity, the r...

Common gene version optimizes thinking -- but with a possible downside

...effects of variation in the human gene for a brain master switch, DARPP-32. The researchers identified a common version of the gene and showed how it impacts the way two key brain regions exchange information, affecting a range of functions from general intelligence to attention. Three fourths of subj...

Keeping the body in sync -- The stability of cellular clocks

...locks that are reset on a daily basis by a central master clock in the brain. The operation of the cellular ...ork like this: the cell receives a signal from the master pacemaker in the hypothalamus, and then these clock genes respond by setting up concentration gradie...

Researchers discover gene crucial for nerve cell insulation

...of Health have discovered how a defect in a single master gene disrupts the process by which several genes interact to create myelin, a fatty coating that covers nerve cells and increases the speed and reliability of their electrical signals. The discovery has implications for understanding disorders of m...

Cracking open the black box of autoimmune disease

... regulatory T cells are themselves controlled by a master gene regulator called Foxp3. Master gene regulators bind to specific genes and control their level of activity, which in turn affects the behavior of cells. In fact, when Foxp3 stops functioning, the body can no longer produce working regulatory T ce...

'Exercise pill' switches on gene that tells cells to burn fat

...ns is now able to chemically switch on PPAR-d, the master regulator that controls the ability of cells to bu...ns discovered the role of the gene for PPAR-d, the master regulator of fat metabolism. By permanently turning on this delta switch in mice through genetic eng...

Virginia Tech's System X supercomputer provides super tool for simulation of cell division

... Panning, who is from Tulsa, Okla., received his master of science in computer science in May 2006 and is currently working as a programmer in Germantown, Md. Watson, of Blacksburg, is professor of computer science in the College of Engineering and professor of mathematics in the College of Science. Allen...

Molecular atlas provides new tool for understanding estrogen-fueled breast cancer

...f -- operated by the cells' estrogen receptor, the master regulator of cell growth in the most common form of breast cancer. The map, which includes thousands of such control regions, provides scientists with a new tool for understanding how genes are regulated, and may eventually help doctors match patient...

'Super' enzyme may lead way to better tumor vaccines

...ng the lives of dendritic cells, the immune-system master switches that promote the response of T-cells, whi...ng) T-lymphocytes." "The dendritic cells are the master switch in the immune system. They decide whether there will be a robust immune response or a tempere...

From a lowly yeast, researchers divine a clue to human disease

...nctions of a key protein that allow it to act as a master regulatory switch -- a control that determines gene activity and that, when malfunctioning in humans, may contribute to serious neurological disorders. The work, published in the Dec. 8 issue of the journal Molecular Cell, shows how a mutation in a ...

Gene therapy research switches off joint inflammation; switches on genetic process of joint repair

...nical products called Reparagen have turned on the master repair gene, IGF-1, which is responsible for growi...hat to rebuild a functional wall that you need the master bricklayer and not just the simple approach of getting more bricks." Elaborating Bobrowski said, "By...

Signaling for cartilage

... cells differentiate into cartilage cells when one master gene actually suppresses the action of another, sa... fibroblasts. “The big question is what are the master genes that make a stem cell go one way versus another,?said Lee. Both SOX9 and RUNX2 are master t...

Jefferson researchers uncover new way nature turns genes on and off

...ioning of homeotic, or HOX, genes, which guide the master developmental plan of the organism. "We think that this new mechanism operates early in embryogenesis," says Dr. Mazo. According to Dr. Mazo, the researchers found that one of the likely mechanisms behind ncRNAs' ability to regulate essential c...

Found -- the apple gene for red

...requires light to be activated." "By identifying master genes that were activated by light, Adam was able to pinpoint the gene that controls the formation of anthocyanins in apples, and we found that in green apples this gene is not expressed as much as in red apples." In collaboration with apple breede...

New angiogenesis finding may help fight cancer growth

...genesis inhibitor. "It's premature to call it a master switch, but intriguingly, it regulates at least four different processes, each of which individually would be anti-angiogenic," says Bresnick. Angiogenesis inhibitors, Bresnick observes, are a fast-growing field of medicine. This June, the Food an...

'Molecular assassin' targets disease gene

... 'one-size fits all' therapy, because it targets a master regulator gene called c-Jun which appears to be in...g the same technology, but focusing on a different master regulator, Egr-1, has also been published this month by Professor Khachigian's group in the Journal ...

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