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Tag: "marker" at biology news

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

...inson's Disease, indicating that it is a potential marker for the disease as well as a potential therapeutic target. ...

High estrogen levels associated with dementia in older men

...igh levels of estradiol are a consequence or early marker of Alzheimer's disease rather than a cause. Some caution is needed when interpreting the results, as, due to death or refusal, some men could not be given a diagnosis of dementia or follow-up cognitive testing. In conclusion, the authors report, ...

Breast stem cells have features similar to 'basal' tumors

...s receptors for oestrogen and progesterone and the marker 'Her2', since these help define the subtypes of breast cancer; and also guide currentapproaches to therapy. The WEHI team, together with the Eaves group in Vancouver, have found that the breast stem cell in mice is 'triple negative' for oestrogen,...

Making a face: A new and earlier marker of neural crest development

...ral tissues. They also identify, Pax7, as an early marker of neural crest formation and prove that its function is required in the earliest stages of development. The neural crest is a population of stem cells that migrate extensively during development and give rise to many derivatives, including most of...

Prozac's target revealed

...en a mystery until now. By profiling the telltale marker proteins produced by different kinds of cells in the brains of adult mice, the researchers first defined discrete steps in the complex process, called neurogenesis, that converts unspecialized stem cells into mature, specialized neurons. Next, knowi...

Movie spies on malaria parasite's sneaky behavior

...y using parasites labeled with a green fluorescent marker and staining the mouse's blood vessels with a red fluorescent marker, Amino was able to record microscopic images inside the animal's liver. He found that not only did the structures Heussler's group saw on the liver cells in the culture dish, called...

AIDS vaccine research offers new insights on survival

...lper T-cells and suggest how they may be used as a marker to gauge the efficacy of these vaccines." The wor..."This second finding provides us with an important marker to use in gauging the vaccine's performance," says Letvin. "By measuring the levels of central memor...

Einstein researchers take the pulse of a gene in living cells

.... Dr. Singer and his co-workers used a fluorescent marker that sticks to the gene only when it is active. Under a microscope, this fluorescent marker appears when the gene turns on, then disappears (gene "off") and then appears again (gene "on"). Th...

Healing the heart with bone marrow cells

...w cells were modified to carry a green fluorescent marker allowing researchers to easily track them. The researchers demonstrated that these bone marrow cells are quickly mobilized to the damaged heart region following a heart attack. Once in the damaged area, the cells produce chemicals that trigger the gr...

A surprise about our body clock

...w cells were modified to carry a green fluorescent marker allowing researchers to easily track them. The researchers demonstrated that these bone marrow cells are quickly mobilized to the damaged heart region following a heart attack. Once in the damaged area, the cells produce chemicals that trigger the gr...

Cutting calories slightly can reduce aging damage

...to oxidative stress, RNA can be useful as an early marker of oxidative damage and even aging," said Arnold Y..., it is important to learn that RNA is a very good marker of aging damage. "I'd never really thought about RNA before," Holloszy said. "Research has always l...

'Smart' genetic therapy helps the body to heal itself

..." The scientists now intend to measure the actual marker of the disease, the very-long chain fatty acids in white blood cells and plasma. If these levels have normalised with valproate, they hope to be able to start a double-blind clinical trial in collaboration with Professor Patrick Aubourg of INSERM, ...

Study provides first look at the 'birth' of a retina cell

...S, Swaroop's team reports that NRL is the earliest marker of rod precursors, or cells that are fated to become rods. They achieved this unique and early view of rod development by creating a mouse model using an NRL regulatory DNA sequence to produce a protein that appears as fluorescent green when exposed ...

Mayo Clinic Cancer Center: Harnessing the measles virus to attack cancer

...alanis. "When the virus replicates, it produces a marker protein that we can detect in the blood using a clinically-available assay. Repeat brain tumor biopsies for this purpose are not always safe or ethically justified. Instead we can monitor viral propagation in the tumor with a blood test, allowing u...

Inflammation markers identify fatigue in breast cancer survivors

... Cancer Center. "We have detected a biological marker that is a composite of two immune response element...nse," Dr. Irwin said. The second component of the marker is an index measured by the level of T cells that are characterized by CD69, a cell membrane protein...

Found -- the apple gene for red

...nt breeders the opportunity to use these molecular marker tests to speed up apple breeding and select for improved fruit colour. Dr Walker believes that this research could open the way to breeding new apple varieties. "With a better understanding of how apple colour is controlled we can begin to breed ap...

Viral marker of human migration suspect

A benign virus previously used as a marker in tracing human migration may be unreliable, acco...populations, JCV has been widely used as a genetic marker for human evolution and migration," explained Shackelton, whose findings appear this month (October)...

High dopamine transporter levels not correlated with ADHD

...levels of a brain protein proposed as a diagnostic marker for attention-deficit hyperactivity disorder (ADHD) are not positively correlated with the disease. In fact, the study found lower levels of these "dopamine transporter" proteins in certain brain regions of ADHD patients compared with controls. The s...

New target for cancer therapy identified

...rase is not associated with benign tumours; it's a marker for malignant tumours only. "If we can control the production of telomerase we can prevent the immortality of cancer cells and therefore cancer formation." Associate Professor Liu and his colleagues have been investigating breast cancer cells to id...

Professors to develop hand-held pathogen testing device

...ashsham's device will be designed to look for such marker genes. "This technology is rugged and highly parallel; it can analyze lots of marker genes in a lot of samples, together with significantly lower false positives," Hashsham said. He ...

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