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Tag: "marker" at biology news

Drug That 'Tags' Decision-making Areas Of The Brain May Aid

...ceptors over time, Nifrolidine couldbe a potential marker for early diagnosis of Alzheimer’s disease,?Mukherjee said.Scientists have known that nicotine’s action on these receptors elicitsdopamine in various brain regions implicated in nicotine addiction andother disorders. Nicotine acts by opening specific...

Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine

...ccording to the review, measurement of one protein marker called ZAP-70 is becoming more widely available. The authors note that ZAP-70 may actually be the most reliable indicator of prognosis known to date. After discussing B lymphocytes -- the type of white blood cell that gives rise to CLL, the biology ...

Researchers trace evolution to relatively simple genetic changes

...ch to focus intense research, using the armor as a marker to see how evolution occurred. Sticklebacks that still live in the oceans are virtually covered, from head to tail, with bony plates that offer protection. In contrast, some freshwater sticklebacks have evolved to have almost no body armor. "It's ra...

Octopuses occasionally stroll around on two arms, UC Berkeley biologists report

...ch to focus intense research, using the armor as a marker to see how evolution occurred. Sticklebacks that still live in the oceans are virtually covered, from head to tail, with bony plates that offer protection. In contrast, some freshwater sticklebacks have evolved to have almost no body armor. "It's ra...

UCSD team discovers specialized, rare heart stem cells in newborns

...he patient. Furthermore, the developmental lineage marker which identifies undifferentiated cardiogenic precursors suggests the feasibility of isolating isl1+ cardiac progenitors from mouse and human embryonic stem cell systems during cardiogenesis." "We think that these cells normally play an important ro...

Increased risk of osteoporosis associated with gene that one in five people have

...ad a higher than normal urinary concentration of a marker that indicates bone resorption and had significant...linked to osteoporosis may be an important genetic marker for evaluating that risk. "Ideally, you want to start early to avoid osteoporosis," Villareal says....

Scientists identify molecule that regulates well-known tumor suppressor

...ors go on to suggest that DJ-1 may be a prognostic marker for cancer patients and be useful as a target for development of future cancer therapeutics. Interestingly, DJ-1 may play a role in other disease states, as it has also been recently identified as a predictive diagnostic for early-onset, autosomal re...

Test for early detection of prostate cancer shows promise

...ncer in its earliest stages. At the same time, the marker successfully avoids the problem of false positive results that plagues prostate-specific antigen (PSA) testing. Study results appear in the May 15, 2005, issue of Cancer Research. The lead author is Robert H. Getzenberg, Ph.D., professor of urology ...

Decoding the logic of olfaction

...map neural activity by measuring the activity of a marker gene called c-Fos in individual neurons across this entire structure. "We found that a single odorant does not just stimulate one or two spots in the cortex," said Buck. "Instead it stimulates a very small subset of neurons that are sparsely distrib...

Genpathway and Baylor College of Medicine Identify New Genes in Breast Cancer

...map neural activity by measuring the activity of a marker gene called c-Fos in individual neurons across this entire structure. "We found that a single odorant does not just stimulate one or two spots in the cortex," said Buck. "Instead it stimulates a very small subset of neurons that are sparsely distrib...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

... not known whether telomerase activation is just a marker for cancer cells or involved in causing it, telomerase is an attractive target for development of anti-cancer drugs by pharmaceutical companies. The research, which was federally funded by the National Science Foundation and the National Institutes ...

Study reveals dramatic difference between breast cancers in US and Africa

...e slightly less likely to express the cell-surface marker HER2. HER2 is the target for the drug Herceptin, which was recently approved for metastatic breast cancer. It is over-expressed in about 23 percent of Caucasians and 19 percent of Africans. Breast cancer strikes fewer women in Africa, "but it hits e...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...pe is to be able to use this system as a molecular marker to assess whether an anti-cancer therapy is workin...and validated, "a CDK2 test would provide the best marker yet for effective use of Tarceva," he says. The only experimental predictive test currently availabl...

Mutation in clams protects against paralytic shellfish poisoning but raises human health risk

...e of that resistance has been shown. We now have a marker that can be used to determine if clams have this mutation. It's easy to use and could help reduce the time of clam flat closures (related to red tide)." Betty Twarog, a neurophysiologist who works at UMaine's Darling Marine Center in Walpole, Maine,...

Virologists make major step towards understanding the process of HIV infection

...tein (GFP) into its genetic information. There the marker protein will be produced by the cellular machinery and appended to the desired site. To observe the interaction of HIV with the host cell, there had also been attempts to label the virus with GFP. However, the genetic modifications impaired the form...

New Species of Coral Discovered Off Southern California

...tein (GFP) into its genetic information. There the marker protein will be produced by the cellular machinery and appended to the desired site. To observe the interaction of HIV with the host cell, there had also been attempts to label the virus with GFP. However, the genetic modifications impaired the form...

Stem cells in bone marrow replenish mouse ovaries

... colleagues discovered. Expression of a germ cell marker in bone marrow fluctuated regularly with the female mouse's estrous cycle, much like the cyclical rise and fall of certain hormones. Further results suggest that the ovary itself is sending out a chemical signal to the bone marrow, readying the proge...

Combination therapy leads to partial recovery from spinal cord injury in rats

...ientists used a modified virus to insert genes for marker proteins that make the cells visible. Some cells also received a gene called D15A. This gene produces a protein with activity similar to growth factors called neurotrophin 3 (NT3) and brain-derived neurotrophic factor (BDNF). Both NT3 and BDNF help m...

Improved statistical tools reveal many linked loci

...inkage between all pairs of a large set of genomic marker sites. The authors found that two-dimensional analysis is not only more computationally demanding than their new method, but also generates ambiguous results because it can be difficult to distinguish whether one or both of the loci being tested are ...

Using nanoparticles, in vivo gene therapy activates brain stem cells

...for example -- took up and expressed a fluorescent marker gene, demonstrating the ability of nanoparticle technology to deliver effectively genes to specific types of cells in the brain. Using a new optical fiber in vivo imaging technique (CellviZio developed by Mauna Kea Technologies of Paris), the UB res...

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