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Tag: "malignant" at biology news

Common cancer gene sends death order to tiny killer

...3's uncanny ability to kill cells likely to become malignant because of damaged genes in their nuclei. MicroRNAs are small chains of ribonucleic acid (RNA) made by the same machinery that produces other types of RNA in the cell, such as the messenger RNAs that carry the instructions to make proteins. Once prod...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

... basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted for 27 per cent of all male c...d at all increased with age, with the exception of malignant melanomas, which showed a decrease in men aged 75 and over. “And there was a link between more pa...

Catching cancer's spread by watching hemoglobin

...hs would be very useful for distinguishing between malignant and benign skin tumors, and would remove the critical need for skin biopsies, which is especially helpful if there are multiple suspicious areas that need to be investigated. Since hemoglobin is highly concentrated in red blood cells, imaging the ...

Effect on breast tumors of DNA alternations in 3 genes described

... normal cell growth to produce proteins that cause malignant behavior, or unregulated cell growth. Until now, data has been very limited regarding the mechanism and causes of hypermethylation, especially for hypermethylation in breast cancer. The purpose of the current study was to determine how DNA hypermeth...

Hexavalent chromium in drinking water causes cancer in lab animals

...s that animals given hexavalent chromium developed malignant tumors. "Previous studies have shown that hexava... in laboratory animals. Male and female rats had malignant tumors in the oral cavity. The studies conducted in mice found increases in the number of benign and...

Gene thought to assist chemo may help cancer thrive

... had normal p53. In the study, researchers took malignant and benign ovarian tumors straight from the operat... didn't consider whether the patients actually had malignant tumors or had been treated with chemotherapy. However, they found that the gene expression profiles...

Leukemia drug turns mini-molecules up, cancer genes down

...uggest that these three miRNAs help re-program the malignant cells to a more normal state," Garzon says, "and that they are also important for normal differentiation." In this study, the researchers used leukemia cells grown in the laboratory and cells donated by patients to study how the drug ATRA affects...

UC Davis researchers use heated nanoprobes to destroy breast cancer cells in mice

...eek out and latch onto receptors on the surface of malignant cells. Three days later, the team applied an alternating magnetic field to the tumor region, causing the magnetic nanospheres latched onto the tumor cells to change polarity thousands of times per second, instantaneously generating heat. As soon a...

Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors

...iagnosed sarcomas were fibrosarcoma (13 patients), malignant fibrous histiocytoma (12), rhabdomyosarcoma (8), and liposarcoma (3). The authors calculated that there was a 184-fold increase in soft-tissue sarcomas among hereditary retinoblastoma survivors compared with the general population and a 390-fold incr...

Breakthrough vaccine to treat chemo-resistant ovarian cancer

...and lung cancer patients, as well as patients with malignant melanomas. ...

Molecular differences between early and advanced melanomas could provide new drug targets

...aling molecule Akt is a primary trigger that leads malignant melanomas on the skin's surface to begin growing vertically beneath the skin and turn into deadly invasive cancers, scientists have found. Understanding this key molecular difference between radial melanomas that spread on the surface of the skin an...

Vasectomy may put men at risk for type of dementia

...ou can use as a parallel," Weintraub said. Certain malignant tumors produce antibodies that reach the brain and cause an illness similar to encephalitis, she noted. The next step in Weintraub's research will be to launch a national study to see if her results will be confirmed in a larger population. "I...

New cell type identified in cancer development

...To cure cancer, we have to eliminate all potential malignant cells ?not just the ones within easy reach." ...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...way. TP53 gene is mutated or deleted in 50% of all malignant tumors. A recently discovered strategy for p53 activation targets the interaction of p53 with its negative regulator MDM2. This is based on a potent and selective small-molecule inhibitor of the p53–MDM2 interaction, the Nutlin-3a, originally discove...

HIV protein enlisted to help kill cancer cells

...e cell-killing effect of radiation. When mice with malignant tumors were treated with TAT-Bim, their tumors shrank, and they survived longer than mice that didn't get the treatment. After 40 days, 80 percent of mice receiving TAT-Bim were alive compared to 20 percent of mice that didn't get the treatment. Ha...

Scientists map key landmarks in human genome

...activity) within seven human cell lines, including malignant melanoma. Nucleosomes are spherical packing units for DNA. They consist of a length of DNA wrapped around a core, like ribbon around a spool that is made up of proteins called histones, and the nucleosomes are located along the chromosomes like be...

Scientists uncover new target in cancer mutation puzzle

...vement, and thus in the progression from benign to malignant cancer, are controlled by two well-known cancer ge...any other potent gene mutations cooperate to cause malignant tumors," said Land, who is professor and chair of the Department of Biomedical Genetics and scientif...

Reversing cancer cells to normal cells

... work led to the first molecular classification of malignant melanoma and may help to explain how, by becoming ...environment. Similarly, during cancer progression, malignant cells receive and release signals from their own microenvironment, cues that promote tumor growth an...

Why don't all moles progress to melanoma?

...lanocyte and triggers a response that prevents the malignant transformation of these cells," Soengas adds. A...oncogenes trigger the unfolded protein response in malignant and non-malignant skin cells. "By comparing what happens in normal melanoctyes with what happens in ...

Molecular 'marker' on stem cells aids research, perhaps therapies

...ells, as well as on embryonic carcinoma cells, the malignant counterparts of embryonic stem cells. Dr. Perlingeiro’s ongoing studies also suggest that the SSEA-4 molecule might be present in other tissues, leading to the intriguing possibility that the SSEA-4 molecule could be a marker for “stemness,?she sa...

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