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Tag: "malarial" at biology news

The insect vector always bites twice

... to be associated with the risk of occurrence of a malarial attack in the following three months. These antisalivary antibodies consequently seem to be indicators of the risk of malaria in endemic areas, that could be used to improve strategies of prevention and care of young patients in the context of season...

Largest synthetic gene ever built offers insights into anti-malarial drug resistance

... tools necessary to molecularly understand how the malarial parasite Plasmodium falciparum (P. falciparum), has become resistant to most of the drugs that could once destroy it. They have already described and expressed two other genes known to confer drug resistance. "Now that we have these genes expresse...

New findings could lead to vaccine for severe malaria

...lopment of vaccines and therapies to combat severe malarial infections. During one particular phase of its lifecycle, the parasite enters human red blood cells, where it produces proteins that attach themselves to receptors in the wall of the blood vessels. This causes the red blood cells to accumulate in or...

Malaria vaccine prompts victims' immune system to eliminate parasite from mosquitoes

...ndividual. The vaccine would not prevent or limit malarial disease in the person who received it. An articl...dium falciparum causing the most severe form. The malarial parasite spends part of its life cycle in humans, and part in mosquitoes. The parasite is injected ...

How bad is malaria anemia? It may depend on your genes

...be most susceptible to this lethal complication of malarial infection and to identify treatments targeted to t...e of diseases, in this case the individual risk of malarial anemia. A number of human proteins, including MIF (which stands for migration inhibitory factor), ...

Malaria, potato famine pathogen share surprising trait

...s infected human red blood cells with the modified malarial pathogen. Results showed that malaria proteins could just as effectively enter and infect a cell when it contained the P. infestans leader sequence instead of its own. "Our findings show that very distinct microbes can share similar strategies for ...

Oxidation defense in mosquitoes benefits malaria parasite

... vector Anopheles gambiae, where XA also helps the malarial parasite reproduce. So stopping the oxidative defense could stop the parasite as well as make the insect a victim of oxidative stress. Rizzi's group at the University of Piemonte Orientale focuses on the structural characterization of enzymes involv...

Malaria parasites develop in lymph nodes

...sites remain in the skin of any mammal bitten by a malarial mosquito until immune cells come along to sweep them out, Ménard said. This second influx of parasites could prompt a somewhat different immune response in the host, and those parasites might have different fates. Parasites developing in the lymph no...

Seaweed yields new compounds with pharmaceutical potential

... battery of pharmaceutical drug targets, including malarial parasite, tuberculosis-causing bacteria, and several cancers. Typically, these tests involve exposing live, disease-causing cells -- parasites, bacteria or cancer cells -- to an extract and then assessing cell death compared to cells that were not...

Old drug, new tricks: Prospects for slashing the impact of malaria

...ergize and more successfully combat any subsequent malarial infection. We suspect that many toddlers who seem reasonably healthy might actually have low level malarial infections that are eliminated by Fansidar, allowing the immune system to develop to its full potent...

Reducing malarial transmission in Africa

...ildren had gametocytes - the infective form of the malarial parasite - in their blood. The numbers of gametocytes carried and how able they were to infect mosquitoes 7 days later was also reduced by the six dose regimen. Although the results are promising, some patients may have difficulty taking a six-dose ...

Scientists reveal molecular secrets of the malaria parasite

...e mosquito."The study highlights the genes in four malarial species that evolverapidly because of "selective p...enome of Plasmodiumfalciparum, the deadliest human malarial parasite.Hall says the Science paper is important because: * The study takes an"evolutionary approac...

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