Mosaic mouse technique offers a powerful new tool to study diseases and genetics
...r by environment--nature or nurture. Our discovery makes us feel that cerebellum wiring is more genetically determined than previously thought." Powerful approach In a companion article published in the same edition of Cell, scientists Todd E. Anthony and Nathaniel Heintz of Rockefeller University descri...Depression gene may weaken mood-regulating circuit
...common versions: short and long. The short version makes less protein, resulting in less recycling, increased levels of serotonin in the synapse, and more serotonin-triggered cellular activity. Previous NIMH-supported studies had shown that inheriting the short variant more than doubles risk of depression ...Motor transport in bio-nano systems
... to the size of its legs. In one second, the motor makes about 100 steps which leads to a velocity of about one micrometer per second. The absolute value of this velocity is not very impressive, but relative to its size, the motor molecule moves very fast: indeed, on the macroscopic scale, its movement wou...Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief
... of medical marijuana. In theory, the new research makes it possible to design a pill that will have the same pain relieving effects as smoked marijuana, but through an indirect mechanism that could also reduce unwanted psychoactive side effects and not have the same political baggage. "There is no prescr...Deep sea algae connect ancient climate, carbon dioxide and vegetation
...press. "Through the energy we consume, each of us makes a contribution to increasing greenhouse gasses, such as carbon dioxide and methane, in the Earth's atmosphere," said Pagani. "To understand the implications of these actions for the future, scientists look to the past to gain a better understanding o...Invasive parasite destroying fish species
...press. "Through the energy we consume, each of us makes a contribution to increasing greenhouse gasses, such as carbon dioxide and methane, in the Earth's atmosphere," said Pagani. "To understand the implications of these actions for the future, scientists look to the past to gain a better understanding o...Stem cells grown in lab mirror normal developmental steps
...press. "Through the energy we consume, each of us makes a contribution to increasing greenhouse gasses, such as carbon dioxide and methane, in the Earth's atmosphere," said Pagani. "To understand the implications of these actions for the future, scientists look to the past to gain a better understanding o...Scientists succeed in cloning human embryos from eggs matured in the lab
...oocytes undergo intensive micromanipulation, which makes it even harder to develop good quality blastocysts... we consider this research is important because it makes best use of more easily available biological material ?in this case, immature oocytes." ...Biologists determine genetic blueprint of social amoeba
...on information we find to humans," Kuspa says. "It makes Dictyostelium a better model for looking for targets against which drugs can act." Key collaborators in the project at Baylor included Richard Gibbs and George Weinstock, co-directors of Baylor's Human Genome Sequencing Center, and Richard Sucgang, ...Invitrogen Launches i-Path -- A Unique Systems Biology Platform at BIO 2005
...oocytes undergo intensive micromanipulation, which makes it even harder to develop good quality blastocysts... we consider this research is important because it makes best use of more easily available biological material ?in this case, immature oocytes." ...Malaria killing a million a year
...challenges as the mosquito-borne parasitic disease makes a comeback, the first joint malaria report from th...ro. "This is just my second day at UNICEF, but it makes sense that my first public statement helps make the case for fighting a largely preventable and utte...Researchers develop new method for facile identification of proteins in bacterial cells
...rchers, is a "shortcut" for preparing samples that makes PMF faster and more economical. By reducing the cost of protein identification, they believe PMF can become an economical tool for monitoring and evaluating the effectiveness of microorganisms used in environmental cleanup. The researchers used a dio...New tool reveals secrets of migrating cells
...escent dye and then hitting them with a laser that makes the dye glow and the cells light up. A certain energy or color of laser light is needed to make the dye, in this case green fluorescent protein, glow. But high-frequency, short-wavelength visible light, like green, doesn't penetrate tissue as deeply ...A virus-like hitchhiker may trigger bacterial meningitis
...One such bacterium, called Neisseria meningitidis, makes its home in the upper respiratory tract, usually without consequence. But certain strains of N. meningitidis -- known as 'hyperinvasive' strains -- occasionally find their way into the blood stream and then into the brain, where they trigger a potent...Fluorescing lab worms signal longer life spans
...ng them, we should ultimately be able to find what makes an animal robust to many different insults." Johnson authored a milestone paper in 1988 showing that mutating a single gene in roundworms could double their life span -- the first evidence that the lifespan of an animal could be increased by genetic...Insects develop resistance to engineered crops
...s express the bacterium in the plant tissue, which makes Bt plants especially effective against insects that bore into stems, such as the European corn borer, which causes more than $1 billion in damage annually in the United States. In greenhouses at the New York State Agriculture Experiment Station in G...Attacks of King George III's madness linked to key metabolism molecule
... PGC-1 alpha, in cells of the liver. The gene that makes PGC-1 alpha was isolated in 1998 in the laboratory...s controlling the activity of the ALAS-1 gene that makes a protein that's crucial to the normal manufacture of heme. A defect in this genetic signaling pathw...Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
...low researchers wrote in the study. The planarian makes an ideal biological model for three important reas... fewer genes to carry out specific functions. This makes it easier to identify a gene's function by silencing it and will help how researchers target their e...New protein vital for immune response is found in surprise location
...s located within the membrane of the mitochondrion makes sense for a couple of reasons, Dr. Chen said. First, proteins housed within the mitochondria have been shown by researchers, such as UT Southwestern biochemist Dr. Xiaodong Wang and others, to play a role in apoptosis, or programmed cell death. The......o the cell's nucleus. The chemical structure of RA makes it hydrophobic, meaning it is barely soluble in water. But the path from the cell cytoplasm, where RA is made, to the nucleus requires passage through water, a difficult journey for a hydrophobic compound. For RA to rapidly enter a cell's nucleus, it...