No small feat: First ever gene therapy success for muscular dystrophy achieved
...inin alpha-2 gene is not possible because its size makes it impossible for researchers to get it to squeeze inside viral vectors ?disarmed viruses that are used to shuttle genes into cells. But the team found a good stand-in in a similar protein called agrin that when miniaturized could be inserted inside ......s -- all in one dynamically overlayable package -- makes BiblioSpherePE even more powerful and essential for molecular biology research." ...Researchers Create DNA-Based Sensors for Nano-Tongues and Nano-Noses
...y. The specificity of single-stranded DNA is what makes these sensors so capable. These biomolecules can be engineered, in a process called directed evolution, to recognize a wide variety of targets, including small molecules and specific proteins. Likewise, the nanotubes are ideal for signalling when th...UCSD discovery may provide novel method to generate medically useful proteins
...y. "Because of its stability, the phage protein makes a better model to create protein diversity in a test tube," explained Jason Miller, a graduate student in Ghosh's lab who conducted much of the research. "Our discovery shows that nature has provided at least two completely different methods to gene...Scientists use gene transfer technology and common virus to block neuropathic pain in animals
...e fibers to reach the neural cell's nucleus, which makes it the perfect gene delivery vehicle for use in th... eight rats in the study. Tying off the nerve root makes the nerve degenerate and release substances that cause pain, according to Fink. A second group of ei...Researchers develop gene therapy to reverse pulmonary arterial hypertension
...tractive target for selective intervention. "This makes the proliferation of lung blood vessels in this di...nge in treating PAH is the fact we don't know what makes the cells in the lung blood vessel wall grow excessively," says the University of Alberta cardiology...Trio of plant genes prevent 'too many mouths'
...ny Mouths, so called because when absent the plant makes too many stomata, or mouths. Scientists were searching for a single stomata gene that had to be working in concert with Too Many Mouths to get an efficient distribution of stomata, Torii says. No one was considering that more than one gene could be ...Cells direct membrane traffic by channel width
...they show that the main structural difference that makes an aquaporin a glycerol channel is a channel that is just a hundred-millionth of a centimeter -- an angstrom -- wider than a normal water channel. So even if glycerol molecules line up properly, as do water molecules to pass through a pure water cha...Genetic variation alters response to common anti-clotting drug
... gene: vitamin K epoxide reductase (VKORC1), which makes a protein that helps control clotting and is the key target of warfarin. The researchers analyzed the VKORC1 gene's DNA sequence in 186 patients on a stabilized dose of warfarin. They searched for common DNA variations responsible for changing the ge...LIAI scientists make major finding on potential smallpox treatment
...ime protects against a bacterial infection. "This makes Dr. Crotty's research even more interesting because his findings appear to offer a way to successfully treat the virus," Kronenberg said. "This could be very important should people become infected before they have a chance to be vaccinated." ...Scientists use gene transfer technology and common virus to block neuropathic pain
...e fibers to reach the neural cell's nucleus, which makes it the perfect gene delivery vehicle for use in th... eight rats in the study. Tying off the nerve root makes the nerve degenerate and release substances that cause pain, according to Fink. A second group of ei...Scientists discover genetic pathway responsible for breast cancer cell growth
...ever, is the molecular mechanism by which estrogen makes breast cancer cells grow. "Until this is solved, we will be no closer to figuring out how to prevent and cure breast cancer," Dr. Giguère noted. Over the past two decades researchers have identified around 20 estrogen-activated genes that play a rol...Fluoride poisoning in China due to clay, not coal
...ide poisoning from consuming too much fluoride. It makes their teeth discoloured and fragile, and in severe cases can distort bones, stiffen joints and lead to paralysis. In Guizhou province, where the problem is most serious, there were 10.5 million cases of dental fluorosis and just over half a million c...Tiny avalanche photodiodes target bioterrorism agents
...t use external filters to become solar-blind. This makes secure battlefield communication possible utilizing a combination of compact, inexpensive UV LEDs and UV APDs both developed at the Center for Quantum Devices. The technology for the realization of solar-blind APDs is based on wide bandgap AlGaN com...How fish hear and make sounds at same time
...n decreases its messages to the ear, which in turn makes the ear more receptive to external sound again. In fact, for an instant following a vocalization, the ear may actually become more sensitive than it was prior to the voicing. By better understanding these complex systems, the study offers new avenue...DDT-resistant insects have additional genetic advantage that helps resistance spread
... in doing so they develop a genetic advantage that makes them and their offspring more likely to thrive even when spraying is abandoned. Researchers warn that the same process may be going on when doctors across the world prescribe antibiotics to cure infections. Antibiotic resistance may potentially conf...UW scientists report a new method to speed bird flu vaccine production
...ibes an improved "reverse genetics" technique that makes it easier to make a seed virus in monkey kidney cells, which, like tiny factories, churn out millions of copies of the disarmed virus to be used to make vaccines. In nature, viruses commandeer a cell's reproductive machinery to make new virus parti...Tiny roundworm's telomeres help scientists to tease apart different types of aging
...tay put just like the cells in adult worms. "That makes our findings relevant for age-related decline in mental function and neurodegenerative diseases, such as Alzheimer's," says Karlseder. "Making people live longer is not enough, we want them to grow old healthy," he adds. "To prevent accelerated agin...Drug resistant avian influenza viruses more common in Southeast Asia than North America
...dvantage in a particular environment and therefore makes the organism more likely to survive and multiply; or a trait that makes it vulnerable to something in the environment, and therefore more likely to become extinct. The inc...... 14, with 7 being neutral. Anything that lowers pH makes the solution more acidic. The scientists calculated that over the past 200 years, the pH of the surface seawater has declined by 0.1 units, which is a 30% increase in hydrogen ions. If emissions of CO2 continue to rise as predicted by the Intergovern...