macrophages 2 2

Tag: "macrophages" at biology news

Chlamydia parasite lives off our fat

...ions, the researchers say. For example, lipid-rich macrophages ("foam cells") are a symptom in chlamydial pneumonia. Because foam cells are a key element in development of atherosclerosis, lipid droplet co-option also suggests a possible explanation for the association between chlamydial infections and heart dis...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

...tsburgh NMR Center for Biomedical Research, tagged macrophages with nanometer (USPIO)- or micrometer (MPIO)-sized...cles. Using MRI, the researchers then track tagged macrophages that infiltrate transplanted hearts. The locations of the tagged macrophages are highly defined and ...

Newly identified mechanism helps explain why people of African descent are more vulnerable to TB

...minent in humans, and the mechanism by which human macrophages kill the tubercle bacillus has remained an additio... from fruit flies to humans. A set of receptors on macrophages in humans called Toll-like receptors contribute to innate immune responses. The researchers describe...

UCSB researchers discover shape matters to macrophages

...t of the body's innate immune system, depends on macrophages ?the cell's clean-up crew. The macrophages find and frequently remove particles from the body. Prior to this discovery, it was believed that th...

Researchers reveal lung's unique innate immune system

...mally on the alert for invaders to kill. Alveolar macrophages are unique among macrophages in the body, because their activation is inhibited by TGFb, a compound expressed in the lung by epit...

Macrophage signaling may affect hormone resistance in prostate tumors

...ween prostate cancer cells and immune cells called macrophages may be a source of inflammatory signals capable of...lored the possibility that external signaling from macrophages in the prostate tumor microenvironment might affect hormone resistance.Using cell biology methods, t...

Researchers map out networks that determine cell fate

...eloped into one of two types of white blood cells: macrophages or neutrophils. Macrophages are the long-lived garbage disposals of the immune system, indiscriminately engulfing and digesting cellular debris and pathogens. The shorter-lived neutrophils are the immune system's vultures, flocking to the site of an ...

Gene transfer using mutant form of good cholesterol cuts vascular plaque and inflammation

...hey facilitate the removal of cholesterol from the macrophages in the plaque and deliver it to the liver for elim...experiment and all three methods demonstrated that macrophages containing the apo A-I Milano gene were more effective in effluxing cholesterol out of them, compare...

Finding the right mix: A biomaterial blend library

...ow two types of model cells--immune cells known as macrophages and bone cells known as osteoblasts--responded to changes in the composition of thin films made of these tyrosine-derived polymers. In practice, many biomaterials are made from blends of polymers to achieve specific material properties. Optimizing th...

Human testis harbors HIV-1 in resident immune cells

...finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological sanctuary—many anti-retroviral drugs have difficulty penetrating this organ and may be present at sub-therapeutic levels. Thus, although HAART may achieve undetectable virus levels in th...

Discovery in the evolution of the immune system absorbing cells

...that there is an evolutionary relationship between macrophages and cells by which both cell types derive from a common, ancestral cell with functional properties of both cells. So though the B cells of lower vertebrates (fish and amphibians) are still capable of phagocytis while they are producing antibodies, th...

White blood cells of cancer-resistant mice overwhelm natural defenses of cancer cells

...ll types of the innate immune system ?neutrophils, macrophages and natural killer cells ?all infiltrate the tumor site in a multi-pronged killing response. "Each cell type had independent killing activity against the cancer cells," the authors said, using different molecules. Macrophages, for instance, have to...

Microbes start immune response by sneaking inside cells

...experiments that exposed mouse immune cells called macrophages to bacteria, Thirumala-Devi Kanneganti, Ph.D., a U-M research investigator in pathology, and Mohamed Lamkanfi, Ph. D, a U-M research fellow, the study’s co-first authors, find that cryopyrin’s call to action inside the cells occurs without requiring ...

In mice, drug protects against diabetes and atherosclerosis

...bes in the blood stream. The aP2 signals encourage macrophages to load up on cholesterol and become "foam cells" that adhere to artery walls, creating dangerous plaques that eventually may rupture and trigger a heart attack. In mice lacking these lipid chaperones, there was no sign of heart disease. Next, the...

1 2