Tag: "macrophage" at biology news

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

...ound. The molecule, called apoptosis inhibitor of macrophage or AIM, inhibits cell death in macrophages, which ...arteries. "The oxidized lipids are cleared out by macrophage cells, but the lipids themselves are very toxic to cells and promote apoptosis (cell death)," Dr. Mi...

Iron exporter revealed that may explain common human disorder

...he iron into hemoglobin. When red blood cells die, macrophage cells consume them and recycle the iron they contain. Macrophages and liver cells also store any excess iron. Earlier work had identified a single protein that imports iron into cells. However, the evidence for ferroportin's role in exporting iron b...

Turning viruses into allies against cancer

...mor immunity stimulant called GM-CSF, (granulocyte macrophage colon stimulating factor). Its job is to induce an immune response to any surviving cancer cells released during the initial viral attack, essentially preventing the spread of these cells to other parts of the body. "This aims to treat metastatic di...

Why do aneurysms form? New studies suggest leading role for white blood cells

.... Days after the injury, far fewer neutrophils and macrophage whit blood cells were present in the aorta walls of the rats that lacked L-selectin. "Much further research is needed, but it's possible that a treatment based on L-selectin could be developed to prevent AAA development in high-risk patients," says ...

Muscle repair: Making a good system better, faster; implications for aging, disease

...a good idea if they're inhibiting repair-promoting macrophage functions; they may give some short-term relief fo...stances. PAI-1 deficient muscles showed "increased macrophage accumulation (and) the extent of macrophage accumulation correlated with both the clearance of (dama...

Scavenger cells could be key to treating HIV-related dementia

...r disease progresses. But understanding the routes macrophage cells take in the brain could help researchers fin...s likely the oldest (form of the) virus lives in a macrophage in the brain and most virus strains evolve from that," McGrath said. "Imagine having cells, already ...

Dangerous tricksters: Some bacterie use immune cells to reproduce

...n = to eat) cuts itself off into the inside of the macrophage and is now the point on which all the macrophage's...sor Haas says, 'since they can then grab a passing macrophage and colonise fresh material.' The next aim of the Bonn researchers is to investigate which bacteria...

Shorter colds, milder flu may follow from newly revealed immune mechanism

...e, it is the opposite. Preventing the death of the macrophage allows the host to ultimately clear the viral debris and so finally halt the infection. Balancing these cell death and survival pathways can determine whether the virus or the host wins the battle." Next, the researchers will look further at precise...

How does Mycobacterium tuberculosis infect the lung?

...ways. They concentrated on a type of cell called a macrophage (the natural target of Mycobacterium) and found that macrophages from patients with TB had much more the DC-SIGN protein on their surface than macrophages from patients with other diseases or from the control individuals. They then took macrophages...

Carnegie Mellon develops non-invasive technique to detect transplant rejection at cellular level

...s transplant rejection non-invasively by observing macrophage accumulation in heart tissues using MRI. "We were able to use MRI to visualize individual macrophages. By tracking individual cells, we also were able to observe, for the first time, that rejection progresses from the outside of the heart to the in...

UCSB researchers discover shape matters to macrophages

...s discovery, it was believed that the ability of a macrophage to process a particle through phagocytosis was dependent solely on its size. Previous studies have been performed only with spherical samples because it was presumed that size was the main issue in phagocytosis, and because fabrication of non-spheric...

Researchers reveal lung's unique innate immune system

...eola is a delicate one, it would be damaged if the macrophage immune system was in a constant battle-ready statu...veola possess a complex immune system in which the macrophage is repressed in its steady state, activated when called upon to fight invading microorganisms, and t...

Researchers map out networks that determine cell fate

...n two related cell types -- in this case between a macrophage and a neutrophil. Then one of two rival "second... of PU.1, they found that the cells activated both macrophage and neutrophil genes. "This showed for the first time how this mixed lineage pattern is set up," S...

Movie spies on malaria parasite's sneaky behavior

...he laboratory have shown that the liver's resident macrophage immune cells happily gobble up free-moving merozoi...chemical "death signal" that would normally tell a macrophage to ingest it. "The parasite did not evolve this complex system for nothing," Ménard commented. "I...

Inhibiting blood to save the brain

..., but an active participant. Fibrinogen activates macrophage cells in the brain called microglia, causing inflammation which damages myelin. The scientists sought to design a therapeutic strategy that would block the damaging effects of fibrinogen without affecting its beneficial blood coagulation. Studyin...

Researchers discover 'acquired' DNA key to certain bacterial infection

...nding the mechanism by how M. avium penetrates the macrophage and infects humans may eventually lead to interventions that can prevent, or at least, reduce the chance of infections, though Bermudez cautioned that it is early in the process. “We still don’t know what most of the individual genes do,” he said,...

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