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Tag: "machinery" at biology news

Carnegie Mellon University research reveals how cells process large genes

...mal cell behavior. But just how a cell's molecular machinery eliminates long introns without making errors has puzzled scientists for years. Now, investigators at Carnegie Mellon University have discovered that a novel mechanism, called recursive splicing, removes long introns by steadily paring them down in...

Gambling monkeys give insight into neural machinery of risk

...ved they have isolated one component of the neural machinery of risk, they do not believe they have mapped the entire circuitry. "We don't think the posterior cingulate cortex is by any means the only area that's important for assessing risk, for deciding what's valuable and for actually making a choice based...

Researchers devise new technique for creating human stem cells

...promise of the fusion technique is in studying the machinery of genetic reprogramming of somatic cells by embryonic cells. "It is extremely difficult to study the reprogramming process using eggs, because in the case of humans it is very difficult to obtain eggs in any quantity and difficult or impossible to g...

Retroviral resistance gene found

...m. We hope that learning more about this transport machinery might reveal a new target for antiviral drugs in the treatment of HIV-1 disease." ...

Genomic sequences processed in minutes, rather than weeks

...Laboratory is speeding up our understanding of the machinery of life -- bringing us one step closer to curing d...llow researchers to understand the body's cellular machinery and discover clues to some types of cancer. And it will help in developing drugs or detection method...

How monarch butterflies are wired for navigation

... path southward. But details of their navigational machinery have remained a mystery. Now, researchers, led by Steven Reppert of University of Massachusetts Medical School, Ivo Sauman of the Czech Academy of Sciences and Adriana Briscoe of the University of California at Irvine, have explored the infinitesima...

It's electric: Cows show promise as powerplants

...e the methane released by livestock waste to power machinery and lights. But converting methane into electricity requires costly equipment : one California farmer reportedly spent $280,000 to convert his operation to a methane digester system. "Methane still needs to undergo combustion, which creates issues w...

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

...ng signals from outside of a cell to the molecular machinery within the cell. GPCRs are the largest family of proteins that serve as drug targets. It has been estimated that at least 40 percent of all medicines on the market act on this family of receptors. ...

Program finds lost genes in nematode genome

...mportant for finding exons, which house the coding machinery of proteins. While getting intron length is helpful for gene annotation, the process is 15 times slower than the typical, less accurate methods. Being able to define intron length has implications for the human genome, which is much larger than C. el...

Cancer drug slows poxvirus in mice

... virus. "This study helps illuminate the cellular machinery used by poxviruses to exit infected cells, and also provides new support for the concept of treating viral infections by targeting specific host cell molecules rather than the viruses themselves," says NIAID Director Anthony S. Fauci, M.D. The senio...

New understanding of cell movement may yield ways to brake cancer's spread

... direction. Guided by this fragment, the molecular machinery needed for cell movement begins accumulating at the leading edge, or front of a cell in response to a variety of chemical messengers, and begins the directed process of migration. The study, led by associate professor and Burnham Cancer Center Acting...

U. Iowa researchers improve Huntington's disease symptoms in mice

...on of toxic protein levels allows the brain cells' machinery to "catch up" with the disease-causing protein and clear out the damage caused by the mutant protein. The genetically engineered or transgenic mouse model used by the UI team carries a section of the human HD gene. These mice quickly develop movemen...

New Species of Coral Discovered Off Southern California

...he marker protein will be produced by the cellular machinery and appended to the desired site. To observe the interaction of HIV with the host cell, there had also been attempts to label the virus with GFP. However, the genetic modifications impaired the formation of virus particles or their infectiousness, t...

Virologists make major step towards understanding the process of HIV infection

...he marker protein will be produced by the cellular machinery and appended to the desired site. To observe the interaction of HIV with the host cell, there had also been attempts to label the virus with GFP. However, the genetic modifications impaired the formation of virus particles or their infectiousness, t...

Natural Killers Could Lead to New Hepatitis Treatments

...nfections, as well as the nature of the regulatory machinery of crawling and stopping. The chemical the researchers used in their experiment is a general immune activator and does not reflect what occurs during an actual infection, he noted. Such knowledge would offer important insights into the mechanism of i...

To Stop Evolution: New Way Of Fighting Antibiotic Resistance Demonstrated By Scripps Scientists

...mmals have evolved to make as few as possible. The machinery inside our cells has the ability to replicate our ...one to some level of damage because no replication machinery is perfect, and with large genomes of billions of bases of DNA to be copied many billions of times o...

Gene therapy cures inherited liver disease in rats

...erm effect. It does not become part of the genetic machinery of the cell and poses no risk of causing cancer, said Lee. "This approach would be applicable to many diseases where you are trying to put something back, targeting the liver," he said. He is hesitant to predict when the treatment can be tried in h...

Researchers develop assay that could be applied to drug screening

...d French scientists, provides new insight into the machinery cells use to internalize cell surface receptors. ...cer and neuro-degenerative disease and the protein machinery of CME has been co-opted by several viruses, including rabies, as a means of entry into healthy cell...

Cellular Defects in Premature Aging Disease are Reversible

...to the mutant splice site and prevent the splicing machinery from cutting in the wrong place. "You can think of it as a molecular Band-Aid®," said Misteli. The researchers inserted their oligonucleotides into the progeria cells and observed that after four days almost all the mutant lamin A transcripts had bee...

Secret of smallpox's success may lead to bioterror cure

...m Jacobs believes that he can turn the biochemical machinery of the pox viruses against themselves ?and protect the public against catastrophic bioterror attacks. And if he is correct, Jacobs may not only be able to create a vaccine that can cure smallpox infections in their early stages, but he may also have...

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