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Tag: "macaques" at biology news

Jefferson scientists find rabies-based vaccine could be effective against HIV

...approach against HIV and related diseases. Four macaques were immunized with both vaccines, while two animals received only a weakened rabies virus. After they gave the animals an initial vaccination, they then tried two different immune system boosts, but didn’t see enhanced immune responses. They then de...

Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps

...dvance in macaque genetics will enhance the use of macaques for the study of genetic diseases of man. ...

Vaccine combined with short-term postexposure antibiotics protects monkeys from inhalational anthrax

...hrax attack. In the study, two groups of rhesus macaques were exposed to very high amounts of anthrax spore...eriod after aerosol exposure. In one study, rhesus macaques were protected during a 30-day course of antibiotics after aerosol exposure. However, some animals ...

Rhesus monkeys in Nepal may provide new alternative for HIV/AIDS research

...he University of Washington report that the Nepali macaques are more closely related genetically to rhesus macaques from India than rhesus macaques of China. This is important because Indian-origin animals have be...

HIV-1's high virulence might be an accident of evolution

...lly susceptible to disease, Kirchhoff said. Rhesus macaques infected with the mutant virus had extremely low viral loads and "either no pathogenicity, or a markedly protracted disease course." Similarly, humans infected with nef-defective HIV-1 progress to disease symptoms slowly, if at all. Several Nef func...

Most human-chimp differences due to gene regulation ?not genes

...enes between humans, chimps, orangutans and rhesus macaques ?representing about 70 million years of evolution. To make the samples comparable, the researchers studied tissue from the liver -- one of the most homogeneous sources -- from five adult males from each of the four species. They focused their search...

A clue from macaques yields evidence for impaired retroviral defense genes in humans

...d because the version of TRIM5 possessed by rhesus macaques allows them to resist HIV infection, whereas the human version does not. Instead, the human version appears to respond to evolutionarily older viruses that are related to now-extinct viruses that are resident in the human genome. Previous studies h...

'Executive' monkeys influenced by other executives, not subordinates

...were pretty striking," said Shepherd. "Low-ranking macaques are extremely fast to follow gaze, while the high-ranking monkeys were pretty blasé about it, being slower to respond." Said Platt, "So, now we have an excellent model of how temperament or status can modulate the strength of these two seemingly ind...

Genetic and environmental influences on alcohol consumption among rhesus monkeys

...onsumption among the non-human primates. "Rhesus macaques provide a good model for many human diseases due in part to their phylogenetic closeness," said Joseph G. Lorenz, research associate at the Coriell Institute for Medical Research and corresponding author for the study. "Also, like humans, they are h...

Diabetes researchers pioneer islet cell xenotransplantation in primate studies

...ch Center for transplantation into diabetic rhesus macaques using an anti-rejection protocol developed by Drs....ity derivative of CTLA4-Ig)9-11 on diabetic rhesus macaques transplanted with neonatal porcine islets. ...

Performing monkeys in Asia carry viruses that could jump species to humans

...he researchers drew blood from 20 urban performing macaques in Jakarta, Indonesia, and tested those samples fo... simian viruses. They found that about half of the macaques tested positive for simian foamy virus (SFV), a primate retrovirus that so far has not been shown to...

Key brain regulatory gene shows evolution in humans

...bonobos, gorillas, orangutans, baboons, pig-tailed macaques and rhesus monkeys. They found significant mutational changes in the regulatory sequence leading to humans that indicated preservation due to positive evolutionary selection. They also found an "evolution-by-association," in which sequences near the ...

'Perception' gene tracked humanity's evolution, scientists say

...es, gorillas, orangutans, rhesus macaques, pigtail macaques and guinea baboons. The researchers found that high genetic variation in the prodynorphin promoter was unique to humans. Other primates' promoters were far more homogeneous. Exactly how prodynorphin influences human perception is unknown. Evidence ...

Primate virus jumps species barrier to humans for first time in Asia

...of simian foamy virus (SFV), a retrovirus found in macaques and other primates that so far has not been shown ...r around a temple in Bali, as well as samples from macaques in the area. They found antibodies for simian foamy virus in the blood of one 47-year-old farmer who...

Norovirus, AIDS vaccine and Hepatitis Virus

... (a protein the virus requires to replicate). Four macaques were injected with the noninfectious vaccine, whil...re challenged with SHIV. All four of the immunized macaques became infected with the challenge virus, but three survived. The two control subjects died. "The r...

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