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Tag: "lymphomas" at biology news

Mutating the entire genome

...es. Many cancers – certain sarcomas, leukemias and lymphomas – start with translocation. Existing methods result in the desired translocation of two chromosomes in one of every 1 million to 10 million cells cultured, Capecchi says, while the new method produces the desired result in one of every 100 cells....

Risk of lymphoma increases with hepatitis C virus infection

...CV) are at an increased risk of developing certain lymphomas (cancers of the lymphatic system), according to a ...preceded development of the lymphoma. The risk of lymphomas in HCV-infected patients was charted across more than five years of follow-up. "This is one of th...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

...imary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki have discovered that activation of the p53 pathway offers a novel effective treatment modality for KSHV-infected lymphomas. The fin...

Short chromosomes put cancer cells in forced rest

... and very long telomeres. These mice all developed lymphomas by the time they were 7 months old. The researchers then continued breeding the mice to see what would happen in later generations. By the fifth generation, the researchers discovered that the mice had short telomeres and stopped developing lymphomas...

Turning a cellular sentinel into a cancer killer

...am used a different technique to reactivate p53 in lymphomas and sarcomas. In their experiments, the researcher...aw two distinct tumor phenotypes," said Jacks. "In lymphomas the responses were rapid, extensive and were accompanied by the induction of apoptosis. In the sarco...

Clue found to Epstein-Barr virus' ability to form and sustain tumors

...s of human cancers, including Hodgkin's lymphomas, lymphomas in AIDS patients and organ transplant recipients as well as nasopharyngeal carcinomas. The SMPH researchers, based at the McArdle Laboratory for Cancer Research, focused on a viral protein they had previously found to be necessary to keeping Burkitt...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

...phoma. It was already known that many human B-cell lymphomas over-express the MYC gene, either because the tumo...ion," Grosveld said. "In fact, all TEL2/MYC B-cell lymphomas had lost their p53 function." Grosveld's team found that this sequence of events modeled in the mou...

Newly Discovered Compound Blocks Known Cancer-Causing Protein

...ounds have shown promise in treating leukemias and lymphomas and are now under consideration for final approval by the U.S. Food and Drug Administration. Since that time, Casey and his colleagues have been studying another key player in the pathway, the Icmt enzyme. Icmt adds a chemical tag called a "methyl g...

Potential Cure for Lymphoma in HIV patients

...rsity ofChicago notes, "The treatment of malignant lymphomas in HIV-infectedindividuals remains challenging, due to both the high incidence ofrefractory disease and the high risk of treatment-relatedcomplications. The ability of high dose chemotherapy as demonstrated inthis pilot study to effectively treat eve...

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