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Tag: "lymphocytes" at biology news

How 'memory' T cells curb the spread of viruses throughout the body

...ccurs when the immune system produces cells called lymphocytes that specifically attack and eliminate the virus a...fection. After the infection subsides, most of the lymphocytes die but some remain in the body as “memory lymphocytes” and protect the body from recurrence of the ...

Major gene study uncovers secrets of leukemia

...es. Normally, the body eliminates differentiated B lymphocytes that have failed to assemble the right genes to ma... supposed to attack. However, if these defective B lymphocytes do not differentiate because of the mutations, the body will not recognize them as defective immune ...

Scientists learn the origin of rogue B cells

...evelopment, for instance, then you would only have lymphocytes that don't express self-receptors at all," he says. For now, the step forward to understand where these self-directed cells are coming from is a big one. "Our objective is to understand the ins and outs of this process," says Casellas. ...

Antibody therapy prevents type 1 diabetes in mice

...ice because the researchers were still able to see lymphocytes in their pancreatic islets, a tell-tale sign of pancreatic inflammation and autoimmunity. In addition, when the researchers isolated cells from the spleens of the antibody-treated mice and injected these cells into immune-deficient NOD mice, seven of...

Mechanisms involved with tumor relapse identified

...tion or cancers. Production of interferon gamma by lymphocytes against tumors is considered a sign of good prognosis; however, recent study findings indicate that this may not be the case. The findings were reported in the March 2007 issue of the European Journal of Immunology, the official journal of the Europe...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

...d stimulate a response in helper T cell clones and lymphocytes in four out of nine melanoma patients. The antigen created no response in cells taken from healthy donors. The study also showed that RPL8 might contain multiple regions that are capable of eliciting an immune response, suggesting that RPL8 may be...

Common blood test can help distinguish between mononucleosis and tonsillitis

...od tests were performed to determine the number of lymphocytes (a particular type of white blood cell involved in the body's immune response) and overall white blood cell count. Total white blood cell count was significantly increased in the tonsillitis group compared with the mononucleosis group (16,560 cell...

How T lymphocytes attack

...e, for the first time in vivo and real-time, how T lymphocytes infiltrate a solid tumour in order to fight it. T...rounds. The rapidity of the advance achieved by T lymphocytes is indicative of either the absence of an adversary, or defeat of the immune system in the battlefie...

Interaction between lymph and liver cells may affect immune response

...first study investigating the interactions between lymphocytes (T cells), liver sinusoidal endothelial cells (LSE...f the images showed a large number of intrahepatic lymphocytes (IHLs) that had extensions similar to the dimensions of the fenestrations of the LSECs. These extens...

Early-stage immune system control of HIV may depend on inherited factors

... of viral protein those molecules display to the T lymphocytes that usually destroy infected cells. In a report ...ss I molecules, which activate the CD8 cytotoxic T lymphocytes that usually destroy infected cells. Although the CD8 response against HIV is ultimately ineffectiv...

Science researchers genetically transform immune cells into tumor fighters

...he patients' immune systems. "We can take normal lymphocytes from patients and convert them to tumor-reactive cells," Rosenberg says, adding that the engineered cells could be tailored to fight tumors other than melanoma. "We've identified T cell receptors that will now recognize common cancers," he notes. T...

Early HIV treatment fails to restore memory T cells

...ry quickly following infection, before the bulk of lymphocytes capable of countering the infection are lost. ...

Environmental toxins may cause body's defenses to worsen lung disease

... says. This will help scientists determine which lymphocytes are important for regulating damage in the lungs, ... ways to "tweak" the immune system and prevent the lymphocytes from causing additional damage to already-injured tissue. Borchers says understanding these pathwa...

Protein splicing upsets the DNA colinearity paradigm

...ly infected, or donated by another person - when T lymphocytes recognize antigenic peptides displayed on the cell surface. The antigens are created by 'proteasomes,' components of the cell machinery that cut foreign proteins into peptides that are then displayed on the cell surface for recognition and destructio...

PNAS study reveals why organs fail following massive trauma

...gned to attack the invader at hand. Unfortunately, lymphocytes too are capable of mistakenly destroying human cells. Thus, they have developed quality control mechanisms where they can choose to stop expanding into an army (anergy) or to commit suicide (apoptosis). The PNAS study offers new evidence that an ov...

Effective HIV control may depend on viral protein targeted by immune cells

... to control HIV focus on the activity of the CD8 T lymphocytes that recognize and destroy virus-infected CD4 T cells, the fact that even patients in the last stages of AIDS can have measurable CD8 responses indicates that those responses are not always effective. To investigate how variations in CD8 response al...

Three-in-one virus killer prevents common, often fatal infections

... of its kind, called Trivirus-specific cytotoxic T lymphocytes (CTLs), which control infections caused by three commonplace viruses ?cytomegalovirus (CMV), Epstein-Barr virus (EBV), and adenovirus. Although benign in people with normal immune systems, the viruses can cause life-threatening illnesses in transplan...

Montreal researchers identify defects of immune cells

...e succeeded in demonstrating that defective CD4+ T lymphocytes primarily determine the susceptibility to oral can...ents who suffer from candidiasis. Defective CD4+ T lymphocytes have long been suspected to be the leading cause of candidiasis, however, it never had been directly...

First human study confirms that immune cells can be a primary cause of bone loss in gum disease

...and his colleagues had found that B cells (B and T lymphocytes are immune cells) can contribute to increased periodontal bone loss coordinating with activated T-cells. Both cell types had previously been found to manifest a host immune response to the bacteria causing bone loss in animal models, by his group. ...

Retinol for combating leukemia cells

... the lymphoblastic cells without affecting healthy lymphocytes nor the rest of the normal cells. Made-to-measure treatment With the molecular action mechanism understood, researchers investigated why retinamide did not affect healthy cells and they discovered other factors to explain the phenomena. So, apart...

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