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Tag: "lymph" at biology news

Spelling out cancer on the nanoscale

... levels of MYC, BCL2, ERK, and AKT proteins in the lymph nodes obtained from patients with Burkitt’s, mantle cell, or follicular lymphoma. The nano-fluidic system reported that MYC was overexpressed in Burkitt’s, while BCL2 was overexpressed in mantle cell and follicular lymphoma patients. In parallel, tra...

Novel mechanism of action of new drug for MS identified

...reventing the egress of white blood cells from the lymph nodes into the blood. The article was pre-published as a First Edition Paper in Blood, The Journal of the American Society of Hematology, which appeared online on Sept. 28. In this study, the research team observed that FTY720 also inhibited the ac...

Novel vaccine shows promise against early-stage breast cancer

...ants received four weekly vaccinations into normal lymph nodes in their groins and were evaluated both pre- and post-vaccination for immune response, level of HER-2/neu expression, and cell infiltrates. The researchers found that most patients responded well to the vaccination. Nearly all patients (11 o...

Radiation after surgery doubles survival time for some lung cancer patients

...ts with lung cancer that has spread to mediastinal lymph nodes ?located between the chest, breastbone and s... overall survival in cancer that has spread to the lymph nodes. In this study, radiation was not randomized nor mandatory but only recommended for patients w...

Interaction between lymph and liver cells may affect immune response

...ture that allows T cells normally activated in the lymph system to become activated by liver cells. Normall...t as APCs, activating T cells independently of the lymph system, a process which makes them less efficient. However, the question remains as to how T cells ...

Short chromosomes put cancer cells in forced rest

...er. A closer look showed microtumors in the mice’s lymph nodes that had begun the road to cancer, but stopped, falling instead into a state of senescence. "They don’t die, they don’t divide, they just sit there in permanent rest," says Greider. Greider, who won the Lasker Award in 2006 for her discover...

Lab research may one day lead to cancer treatment using patient's own immune cells

...s on identifying and harvesting T cells within the lymph nodes of patients, activating these T cells and growing them in culture in the laboratory over one to two weeks. The T cells are activated with molecular agents called interleukin-2 and anti-CD3 antibody (OKT3). It is hoped that results from thi...

Napoleon's mysterious death unmasked, UT Southwestern researcher says

...es cancer size; the "N" designates the presence of lymph nodes, which are associated with tumors; and the "...other accounts indicate that the cancer was large, lymph nodes were present around the stomach and there were no tumors in other organs. Only 20 percent of p...

Why doesn't the immune system attack the small intestine?

...-Farber identify an unlikely group of peacemakers: lymph node cells that instruct key immune system cells t...ack," says Turley. "Because the cells are found in lymph nodes throughout the body, they may offer a way of suppressing a variety of autoimmune diseases," wh...

Molecular differences between early and advanced melanomas could provide new drug targets

...idly, to 64 percent if the disease has reached the lymph nodes and 16 percent if it has spread to other organs. The discovery of Akt's significant role in the progression of melanomas was made by scientists in the Department of Dermatology at Emory University School of Medicine and published in the Marc...

Woven scaffolds could improve cartilage repair

...ause the tissue lacks a supply of blood, nerve and lymph and has limited capacity for repair. Current strategies for treating cartilage damage, such as surgery or cartilage implants, are fairly limited, said Farshid Guilak, Ph.D., director of orthopedic research at Duke and senior member of the research...

Anthrax paralyzes immune cells with lethal toxin, UF research shows

...nthrax often suffer hemorrhages in their lungs and lymph nodes. "No one understands why, and it could very well be due to paralysis of platelets." During and Southwick are currently looking for additional proteins targeted by anthrax. They hope to develop a diagnostic blood test that detects the bacterium ...

How 'memory' T cells curb the spread of viruses throughout the body

...onal Academy of Science Online Early Edition shows lymph nodes are not just organs where immune cells resid...lls normally reside in lymphoid organs such as the lymph nodes. It was thought that to protect from disease, memory CD8 T cells needed first to multiply in ...

Migration alert -- How tumor cells home in on the lymphatic system

...erapeutically, it indicates that a drug target for lymph node metastases could be blocking the signaling molecule or its receptor on the tumor cell.”...

New bacterium discovered -- related to cause of trench fever

... scratch disease, an infection that causes swollen lymph nodes and fever after a cat scratches its owner or an unlucky visitor. They were again surprised to find that this microbe is the second Bartonella species to cause infection in AIDS patients. Like trench fever, cat scratch disease had been desc...

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