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Tag: "lymph" at biology news

Scientists directly view immune cells interacting to avert autoimmunity

Using a new form of microscopy to penetrate living lymph nodes, UCSF scientists have for the first time vie...ning microscopy, was able to focus deep within the lymph node of a diabetic mouse, allowing the researchers to show that immune cells known as T regulatory, ...

Source of crucial immune cell in the skin discovered

...antigens present in the skin and transport them to lymph nodes, activating the immune system to protect the...ely on these cells to transport the antigen to the lymph nodes to trigger an immune response against the tumor." Once Langerhans cells transport an antigen,...

New evidence questions the simple link between prion proteins and madcow disease

...e first tissues to accumulate infectivity would be lymph nodes in the throat or the tonsils. But we don't tend to see this in animals, and have no reason to believe it would be different in humans," comments Jeffrey. ...

Simple idea to dramatically improve dengue vaccinations

... infected cells and brings pieces of them into the lymph node for targeting. Within a few days of infection...e by taking advantage of the relative isolation of lymph nodes throughout the body. Each person has hundreds of lymph nodes. Deem believes vaccinations at fo...

Researchers reverse juvenile diabetes in animal model

...to the abdominal/pelvic area near the pancreas and lymph nodes, blocks the T cells as they travel to the pancreas to destroy beta cells. "We did this in mice, giving them six injections over the course of several weeks. The injections interrupted the T cell and beta cell interaction, allowing the beta ce...

Malaria parasites develop in lymph nodes

...e parasites developing in an unexpected place: the lymph nodes. The parasites' presence in the lymph nodes almost certainly has implications for the mammalian immune response, said Robert Ménard, a How...

Front-line immune cells mature in four stages, study shows

...s in secondary lymphoid tissue such as tonsils and lymph glands. Key discoveries made decades ago in anim...The next step is to figure out why they develop in lymph tissue and whether patients with cancer have altered NK cell development." Scientists have known f...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...h a microscope to document what happens inside the lymph nodes of a living mouse shortly after a vaccinatio...of understanding how CD8+ T cells move through the lymph nodes and become activated. Once active, CD8+ T cells roam throughout the body destroying cells infe...

Avian influenza virus in mammals spreads beyond the site of infection to other organ systems

...digestive tracts, liver, kidney, heart, brain, and lymph nodes. Furthermore, examination of infected tissues revealed cellular damage at sites containing viral proteins, providing an explanation for the increased severity of disease in humans. These data underscore the potential for influenza virus to sp...

Scientists discover a new disease-causing bacterium in an immune-compromised patient

...stem. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death....lated the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism ...

Soil-bound prions that cause CWD remain infectious

...stem. In the patient, the bacterium caused fever, lymph node inflammation, and weight loss, but not death....lated the new bacterium from the patient's swollen lymph nodes and demonstrated its pathogenesis. "Our first concern was to determine whether this organism ...

Molecular force field helps cancer cells defend against attack

...e protein is tied to the growth of channels in the lymph system that serve as cellular superhighways for cancer spread and is found in breast, colon and thyroid tumors. Cance and colleagues were the first to pull FAK out of human tumors and to show that human cancers make the molecule in large quantities....

Newly discovered killer cell fights cancer

...e main messenger center of the immune system - the lymph nodes. Here, they found approximately 35 percent of the original group of IKDCs now secreting communication molecules signaling a switch to messenger-mode. Simultaneously, Housseau's colleagues in France, led by Laurence Zitvogel at the Institut Gu...

APS lecturer shows rare video of 'teacher-student' immune cell interactions in live animal

...ed a real-time look at what happens inside a mouse lymph node when a foreign microbe enters the body. The v... footage "Before this, what had gone on inside the lymph node was largely a black box." His team published their first work using the new approach in January...

Mayo Clinic study finds two genes predict outcome for breast cancer patients

...tifying women with a higher risk in the setting of lymph node-negative breast cancer." The study, which ... marker of early breast cancer relapse or death in lymph node-negative breast cancer. "We believe that these findings are clinically important and corrobora...

New genetic test for breast cancer

...itive breast cancer that has not yet spread to the lymph nodes. The standard treatment is surgery to remove the tumor, plus radiation and hormonal therapy, which cures about 80 to 85 percent of patients. Adding chemotherapy can further reduce the risk of recurrence by about 25 percent, but it benefits ...

First-ever genomic test predicts which lung cancer patients need chemotherapy to live

...ize of the patient's tumor, whether it has invaded lymph nodes and whether it has spread to other organs. They use this staging method to prescribe the best treatment options. But staging parameters are general, at best, and do not accurately define who should receive chemotherapy, Nevins said. "Instead...

Tumor wizardry wards off attacks from the immune system

...ase in T-reg cells in both the blood stream and in lymph nodes leading from the tumors. When the research...cells were no longer present in the tumor-draining lymph nodes, suggesting that this signaling molecule, referred to as TGF-beta, has an important role in we...

Second opinion yields treatment changes for half of patients

...y to make breast conservation possible or sentinel lymph node biopsy, a new technique to determine whether cancer has spread beyond the breast. Thirty-two percent of patients had their surgery recommendations changed based on a multidisciplinary approach to surgical management The researchers found radi...

HIV exploits competition among T-cells

...he approach capitalizes on the fact that different lymph nodes ?the sites where T cells compete to be chose...ecause it takes 4-5 days for T cells produced in a lymph node to begin to leave it, the possibility exists to set up simultaneous, independent competition ag...

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