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Tag: "lupus" at biology news

Genes In The Interferon System Important In Systemic Lupus Erythematosus

... very strong associations withthe disease systemic lupus erythematosus (SLE) have been identified bya team of scientists headed by researchers at the Department of MedicalSciences at Uppsala University. The findings are being published todayon the Web page of the highly prestigious American Journal of Huma...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

...tself, as in autoimmune disorders such as systemic lupus erythematosus. When viruses activate innate B cells, the body destroys the B cells to protect against autoantibodies that could cause autoimmune disease or other harm. The second immune system category is adaptive B cell immunity, a slower response ...

Multi-purpose protein regulates new protein synthesis and immune cell development

...mmune diseases, like myasthenia gravis or systemic lupus erythematosus." Results from the study will be published in the Feb. 1 issue of the Journal of Clinical Investigation. Kaufman studies fundamental signaling pathways involved in the production of new proteins in the cell's endoplasmic reticulum (...

New Lab Research May Help Those Deafened By Immune System Attack

... people with systemic autoimmune disorders such as lupus or rheumatoid arthritis. Such people may be prone to losing all or part of their hearing due to an overzealous autoimmune reaction. All eight study participants who had systemic autoimmune diseases showed signs of antibodies against IESCA. Six of the...

Yale scientists identify structure for RNA quality control

...ity control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known ...ity control. In the autoimmune disorders systemic lupus erythematosus and Sjogren's syndrome, Ro is known to be an autoantigen, and autoimmune disease devel...

Langerhans cells regulate immune reactions in the skin

... underlying many skin disorders such as psoriasis, lupus and skin cancer. Dendritic cells are found throu...esult in chronic inflammatory skin conditions like lupus and psoriasis, said Shlomchik. "This is the new theory we would now like to test." The findings co...

Infection 'alarm' yields clues to immune system behavior

...m-related ailments including septic shock, cancer, lupus and rheumatoid arthritis. Their findings, which focused on how a large protein molecule called tumor necrosis factor, or TNF, triggers an immune response, were reported in the February issue of the Journal of Biological Chemistry. "We were surprise...

Researchers map of genetic variations implicated in disease

...e of diseases, including type 1 diabetes, systemic lupus erythematosus and myasthenia gravis. The PGF haplo...r diseases such as multiple sclerosis and systemic lupus erythematosus. The QBL haplotype is positively associated with Graves' disease and type 1 diabetes. ...

U-M scientists identify major psoriasis susceptibility gene

...e also used for other autoimmune diseases, such as lupus and rheumatoid arthritis. These drugs turn off the immune response, which leaves the body vulnerable to infection. Now that U-M scientists have identified HLA-Cw6 as being the PSORS1 gene, Elder says scientists can concentrate on finding ways to bloc...

How can we protect patients with weakened immune systems from influenza?

...n abnormal immune system turns on itself: systemic lupus erythematosus and Sjogren's syndrome. Core research facilities will assist all the projects in systematically measuring T cell and B cell counts and developing specialized assays. The researchers will begin enrolling patients this fall under the fiv...

Epstein-Barr virus may be associated with multiple sclerosis

...o other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the body's own tissues, the authors conclude. "A fine understanding of the mechanisms that c...

Big hips, big belly? It's in your genes, Joslin-led study shows

...o other autoimmune diseases, particularly systemic lupus erythematosus (lupus), suggests that Epstein-Barr virus may have a broad role in predisposing to autoimmunity," or failure of the immune system to recognize the body's own tissues, the authors conclude. "A fine understanding of the mechanisms that c...

Can you hear me now? Scientists find previously unknown receptors on adult stem cells

...treating leukemias and autoimmune diseases such as lupus and rheumatoid arthritis. "We have long known tha...hat could provide a powerful tool to fight cancer, lupus and many other diseases." ...

A single sugar found responsible for an antibody's ability to treat inflammation

...matory autoantibodies in autoimmune diseases, like lupus and arthritis, less inflammatory. The next logical step then, Ravetch says, was determining how the IgG molecules in IVIG preparation could have an anti-inflammatory effect. Because a therapeutic, anti-inflammatory response to IVIG requires a co...

Drug dials down the energy within cells, UM researchers find

...es effects of arthritis and the autoimmune disease lupus in mice and may be useful in treating psoriasis. Unlike conventional drugs for these conditions, which can't discriminate between healthy and disease-causing cells, Bz-423 is highly selective, homing in on disease-causing cells. In an attempt to bet...

Research suggests beta agonists may alter the immune system

... worsen diseases such as asthma, heart failure and lupus that involve inflammation. The scientific team led by Raymond Penn, Ph.D., and Matthew Loza, Ph.D, found that beta-agonists, such as those used in the treatment of asthma, increase the accumulation of type 2 T cells, a type of white blood cell that ...

New insights into autoimmunity and depression

Systemic lupus erythomatosus (SLE), often simply called lupus, is a complex autoimmune disease marked by joint pain, skin rashes, extreme fatigue, and depression, among other symptoms. Some studies have described a possible link between SLE’s most severe psychiatri...

A revolution in the monitoring of unborn babies

...e diabetes, autoimmune conditions such as systemic lupus erythematosus and Sjogren’s syndrome and obstetric cholestasis. It will also be useful in monitoring fetuses identified as growing poorly or where it is suspected that the placenta is unhealthy and hence the fetus may become compromised due to lack o...

Cracking open the black box of autoimmune disease

Autoimmune diseases such as type 1 diabetes, lupus and rheumatoid arthritis occur when the immune sys...ciated with type 1 diabetes, rheumatoid arthritis, lupus and Graves' disease, but the gene had not been previously linked to regulatory T-cell function," say...

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