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Tag: "lung" at biology news

Discovery could aid fight against cystic fibrosis infection

...their lungs. Once a PA infection in a CF patient's lung has been established, these hardy bacteria are difficult or impossible to clear, which over many years eventually results in the death of the patient. Our paper provides evidence that the protein secretion system we discovered represents at least one...

NYU algorithm enhances ability to detect cancer genes

... map the set of tumor-suppressor genes involved in lung cancer. The algorithm uses data from Affymetrix's gene-chips that can scan hundreds of patients' genomes to find gains and losses in gene-copies. The findings will appear in the July issue of the American Journal of Human Genetics. The study was con...

Mouse study reveals new clues about virulence of 1918 influenza virus

...topsy samples show extreme and extensive damage to lung tissues. This observation gave rise to the hypothe...ncontrolled inflammatory response leading to rapid lung failure and death. To test this idea, Dr. Tumpey infected mice intranasally with one of four type...

Combination therapy shows promising results in patients with advanced lung cancer

...oduced promising results in patients with advanced lung cancer, researchers at UCLA's Jonsson Cancer Cente...ammatory drug Celebrex increased response rates in lung cancer patients by about three-fold, said Dr. Karen Reckamp, an assistant professor of hematology/on...

New finding points way to foiling anthrax's tricks

...e bacteria succeed by forming capsules that invade lung cells, then capturing iron in order to reproduce, and finally, manufacturing a toxin that kills the cells and releases thousands of new spores into the bloodstream. Because the iron-capture stage is critical to growth, it has become a recent focus...

Killing brain tumors from within: A 'Trojan horse' approach

...o successful therapy in treating leukemia and some lung cancer patients....

Minorities, uninsured less likely to receive care at high-volume hospitals

... esophageal cancer resection, hip fracture repair, lung cancer resection, cardiac valve replacement, coronary angioplasty, pancreatic cancer resection, and total knee replacement. According to this database, a total of 719,608 patients received 1 of the 10 operations. The researchers found that "in gene...

Halving daily cigarette quota has no health benefit

...an 15 cigarettes a day). Among men, deaths from lung cancer and cancers associated with smoking were not significantly lower in those who had cut back compared with heavy smokers. But this was not true of women who cut back, where the reverse was true. And men who cut back only had slightly lower de...

Novel EGFR ectodomain mutations in glioblastoma

...n to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers have catalogued and characterized the mutations in the EGFR gene that occur in glioblastoma, a deadly type of brain tumor. The researchers sequenced the whole coding sequence of the EGFR gene in mo...

Very low birth weight linked to reduced quality of life in pre-school children

...general, children with low birth weight had poorer lung function, appetite and motor function than normal birth-weight children, as well as being more anxious, less positive and less lively. Premature babies delivered before 28 weeks were much more likely to have a lower quality of life when it came to ...

Gene therapy for hereditary lung disease advances

...ficiency, a common hereditary disorder that causes lung and liver disease, has caused no harmful effects i...y counteracting inflammatory products that destroy lung tissue. But about 100,000 Americans have alpha-1 antitrypsin deficiency, according to the Miami-base...

Cigarette smoking impedes tendon-to-bone healing

... physical problems, from cardiovascular disease to lung disorders. Many of us probably don't think about smoking's effects on orthopaedic conditions, but several studies have shown that nicotine interferes with healing of bone fractures and also inhibits bone fusion processes -- many spine surgeons, for e...

Common cold virus leads to death in lung transplant patients

... of most common colds, struck two immunosuppressed lung transplant patients, leading to progressive respir... infection and its potential clinical impact on 69 lung transplant recipients at two centers. Over a 19-month period, they screened all lung transplant pati...

Antioxidant protects against lung damage in silicosis

... levels correlate significantly with their primary lung function test level and vital capacity. (Vital cap... after a maximum inhalation, showing the status of lung tissue.) The authors believe that if serum HO-1 derives primarily from lung lesions, it could als...

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis

...sis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not ...of conventional methods used to assess survival in lung cancer patients. The interest in and the knowledge of gene expression profiling in medical science ...

'Tribbles' protein implicated in common and aggressive form of leukemia

...shan, "C/EBPa defects have also been identified in lung cancer and other tumors, suggesting the possibility that Trib2 dysregulation may be identified in other tumors. Furthermore, linking Trib2 to human cancer adds further support to the notion that targeting the protein degradation machinery will be a u...

Abnormal overexpression of p53 is a predictive molecular biomarker

...e when used with radiation to treat non-small cell lung cancer. ...

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

...GFR mutations that are responsible for one form of lung cancer. These cancers can be treated with the targeted therapies Gleevec and Tarceva, respectively, which shut down the affected oncogenes. The test involves taking a sample of fresh or frozen tumor, amplifying its DNA, and then searching for 250 kn...

Successful lung cancer surgery not enough to break nicotine dependence in many smokers

... 154 smokers who had surgery to remove early stage lung cancer picked up a cigarette again within 12 month...er said. No such programs are currently offered to lung cancer surgery patients, he added. At least seven studies of non-small cell lung cancer patients ...

Researchers discover that sheep need retroviruses for reproduction

...ogenous Jaagsiekte Sheep Retrovirus or JSRV causes lung tumors in sheep and led to the death of Dolly, the world's first mammal cloned from an adult cell. The idea that endogenous retroviruses are important for reproduction in mammals has been around for about 30 years, Spencer said. Studies in cultured c...

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