Muscle repair: Making a good system better, faster; implications for aging, disease
...increase with aging, and may explain, in part, the loss of repair capacity as we age. Koh plans to see whether manipulating PAI-1 levels can restore muscle repair in old muscles. * PAI-1 levels also appear to be higher in muscle diseases like Duchenne Muscular Dystrophy. In such diseases, muscle repa...Change in gene may be underlying molecular defect in some colorectal cancers
...eral subjects who did not have cancer. "Because a loss of MGMT protein function is a plausible predisposing factor for cancer through the increased occurrence of mutations? our data indicate that MGMT promoter methylation may qualify as a marker of the field defect in colorectal cancer," the authors writ...Researchers have discovered that the loss of a gene called p63 accelerates aging in mice. Similar versions of the gene are present in many organisms, including humans. Therefore, the p63 gene is likely to play a fundamental biological role in aging-related processes. "To study how the p63 g...Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models
...cientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that is crucial for the development of Alzheimer's disease. "What we are showing is a proof of principle that stopping the synthesis of a protein that is necessary for the formation of the telltale plaques reverse...Newly Discovered Role for Heart Response Enzyme May Yield Better Heart Failure Therapy
... exercise or stress, as well as in the progressive loss of heart function that is heart failure, the resea... Rockman, M.D., of Duke. "If we could prevent this loss of heart receptors, we might improve heart function in patients with heart failure." The enzyme the...Hanging baskets of sex and death help fruit growers
...in a very targeted way to other moths and prevents loss of populations of other beneficial insects such as the red spider mite which would occur if growers used pesticides. Extended virus life - The virus does not fare well in direct sunlight. Growers who currently spray the virus find it quickly becomes...Use of high hydrostatic pressure to inactivate Hepatitis A virus in oysters studied
...ction is characterized by fatigue, malaise, fever, loss of appetite, nausea, vomiting, joint and muscle aches, and abdominal pain, coupled with the onset of jaundice, a yellowing of the whites of the eyes, and dark urine. The disease generally runs its course in two months, but can linger as long as six. ...Traditional models underestimate extinction rates
... extinction. The biggest threat to most species is loss of habitat. And as habitat loss and degradation proceed nearly unabated, the need to accurately predict the population dynamics and ...From a Few Wild Ancestors, a Citrus Cornucopia
...he area of origin because of the threat of habitat loss and the political challenges surrounding international exchange of plant materials.?/p> Citrus In Situ In situ preservation—conserving plants and organisms in their indigenous habitats—offers research opportunities available nowhere else. Like o...Stem cells bring fast direct improvement, without differentiation, in acute renal failure
...most serious form of ARF is caused by ischemia, or loss of blood supply to the kidneys caused by shock, bl... ARF therapy for decades. "Basically, catastrophic loss of kidney function has remained treatment-resistant despite dialysis and intensive care. Treating pa...Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure
... between the severity of the infection and greater loss of brain matter. In methamphetamine abusers who are also HIV-positive, decreased volumes are correlated with increased cognitive impairment in one brain region, the hippocampus. Dr. Jernigan explains that the changes seen in brain structures could ...Disappearing arctic lakes linked to climate change
... completely they shrank significantly. The overall loss of lake surface area was a loss of approximately 6 percent. In addition, 125 lakes vanished completely and are now re-vegetated. La...... system. This stress, together with the continuous loss of circulating bacteria throughout the system, reduces the formation of biofilm even at extremely low levels ?and maintains this to such an extent that the fixing of "legionella" bacteria or any other micro-organisms needing biofilm in order to grow ...Acid water in East Java threatens biodiversity and local welfare
...the river at various locations. She determined the loss dry matter over a period of several months. Solution According to Lohr, one possible solution for the acidification problem is simply to prevent the crater water from mixing with both neutral rivers. She believes that this could be realised by c...Israeli scientists successfully transplant frozen-thawed ovaries in sheep
...sing this technique[3]. However, adhesions and the loss of blood to the ovarian follicles that occurs duri...transplants, as well as helping women who face the loss of their fertility." The research may also have far-reaching applications for animals. The team rec...Researchers discover new tumor defense system
...blished tumors for a number of reasons including a loss of the ability of the cytotoxic T lymphocytes to recognize the tumor and a physical barrier separating the lymphocytes and the tumor. Now, Dr. Alan M. Kleinfeld and Clifford Okada of the Torrey Pines Institute for Molecular Studies in San Diego, CA,...Exercise aside, genes may ultimately dictate seniors' mobility
...lity, are common aspects of aging that can lead to loss in quality of life, Pahor said. Understanding the ... ID genotype displayed the lowest rate of mobility loss in any exercise category. In contrast, weight trainers with the II genotype developed physical limit...Quick identification needed to save Florida's citrus industry from devastating disease
...on methods are needed to reduce the amount of crop loss caused by this disease, say plant pathologists with The American Phytopathological Society (APS). Citrus greening is a bacterial disease that affects the phloem system of citrus plants causing the infected trees to yellow, decline, and possibly die w...Birds and bats sow tropical seeds
...a destructive cycle of land fragmentation, habitat loss and -- even with replanting using wind-dispersed trees -- species loss. Howe and his colleagues will lease 16 land parcels in Veracruz located near or adjacent to forest remnants or UNAM's protected rainforest to observe what trees grow, and why. So......to explore the causes of human deafness. "Hearing loss is a major pathology that humans deal with," said Bass. "And we don't understand that mechanism very well. Observing what these neurons do may offer insights into what leads to hearing deficits." Only a few fish vocalize, but male plainfin midshipma...