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Tag: "loss" at biology news

Insight into DNA's 'weakest links' may yield clues to cancer biology

...merase exhibited higher frequencies of chromosomal loss and aberrations than normal, resulting when broken chromosomes re-joined with others to form novel arrangements, the researchers reported. Through further examination of breakpoints in a small region of one chromosome, the researchers found that the...

Chromosome Deletion Predicts Aggressive Neuroblastoma

...location designated chromosome 11q23. However, the loss of material at that site apparently removes the protective effect of a tumor suppressor gene, and thereby allows the tumor to grow. Patients in the study with the chromosome deletion had a three-year overall survival rate of 66 percent, compared to 8...

UCSD research reveals mechanism involved with type of fatal epilepsy

...nd malin, but the molecular mechanism defining how loss of laforin or malin causes Lafora disease has remained unclear. Jack E. Dixon, Ph.D., UCSD dean of scientific affairs and professor of pharmacology, and colleagues at UCSD investigated the role of malin in Lafora disease and found that malin physica...

NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses

... the p21 gene accelerated tumor formation and that loss of this gene eliminated the ability of sulindac to...rous polyps. They found that on the AIN-76A diet, loss of one APC gene but retention of the "wild-type" (normal) p27 genes was enough to induce tumor forma...

Putting ecology back into river restoration

...le, a channel modification project should minimise loss of native vegetation during river reconstruction, and should avoid the fish spawning season for construction work," Palmer explains. The final criteria is ecological assessment. According to Palmer: "It is critical that the broad restoration communit...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...first study, M. D. Anderson researchers found that loss of the CDK2 enzyme strongly correlated with a cancer's sensitivity to Tarceva. That means testing activity of CDK2, the enzyme that drives cell division, can reveal whether or not a tumor will respond to Tarceva, says Naoto Ueno, M.D., Ph.D., an ass...

Cellular Defects in Premature Aging Disease are Reversible

...ths, and physical symptoms include stunted growth, loss of hair and body fat, joint stiffness, osteoporosis, and heart problems. The condition is fatal, with heart disease being the leading killer, and affected children usually die before they reach their late teens. Less than two years ago, NIH-led rese...

Man-made wetland's effectiveness similar to natural marsh

...n the last two centuries, compared to a 50 percent loss overall in the lower 48 states. About 577,000 acres of wetlands have already been created or restored under current conservation programs, Mitsch said. But about 10 to 25 times that many are needed in the Mississippi watershed region in order to see...

Of mice and men's (and women's) contraceptives

...roduce no functional sperm, and females show early loss of eggs and defects in ovulation. The MSY2 protein is part of a family of proteins, called Y-box proteins, that are present in most organisms, ranging from bacteria to humans. In the nuclei of developing germ cells, MSY2 enhances synthesis of a sele...

Tendency to hair loss inherited from the mother

...gs are also interesting for the aspect of how hair loss is inherited. The gene for the androgen receptor l...or more volunteers. "Men under 40 with severe hair loss can take part," Dr. Kruse says. "If they have a brother who is affected and the parents are also pre...

Gene keeps neural cells on correct developmental path

...nts of as many as 1,000 genes at once. The gradual loss of REST in differentiating neurons probably orchestrates a precise sequence of genes sensitive to different levels of REST, Mandel speculates. REST has been a difficult gene to study. Using knockout technology -- a popular technique for determining ...

Too much water may be as dangerous as too little during long-distance athletic events

...r developing hyponatremia, a condition marked by a loss in the body's sodium content that can result in ph... always include enough sodium to offset the body's loss of the mineral during exercise. The drinks often carry more water with smaller concentrations of sal...

Bush, Cheney and Rumsfeld are now species of slime-mold beetles -- but strictly in homage

...r developing hyponatremia, a condition marked by a loss in the body's sodium content that can result in ph... always include enough sodium to offset the body's loss of the mineral during exercise. The drinks often carry more water with smaller concentrations of sal...

New design : complete

...r developing hyponatremia, a condition marked by a loss in the body's sodium content that can result in ph... always include enough sodium to offset the body's loss of the mineral during exercise. The drinks often carry more water with smaller concentrations of sal...

Currents could disrupt ocean food chain

...and in some areas, such as the North Atlantic, the loss could hit 50 percent. The study was conducted by Andreas Schmittner, an assistant professor in the College of Oceanic and Atmospheric Sciences at Oregon State University. In his sophisticated computer model, Schmittner does not predict that the Atla...

Important discovery about second most fatal cancer

...ancers often occur in young subjects and result in loss of many years of life. An appreciation of the problem can lead to cancer prevention by a combination of prevention or detection of early cancer. 2. High-risk families provide an opportunity for investigating novel approaches of cancer prevention by ...

Molecular messengers perform a crucial role in the ability of injured nerve cells to heal themselves

... vimentin, which protects them from dismantling or loss of the phosphorus. Vimentin links up to motor proteins that carry the message along the axon, and thanks to this linkage and protection, the messengers can safely transmit their message, thus bringing the injured axon's call for help to the cell body...

Primates on the brink

...t of Brazil, and Western Ghats-Sri Lanka. Habitat loss due to the clearing of tropical forests for agriculture, logging, and the collection of fuel wood continues to be the major factor in the declining number of primates, according to the report. Hunting for subsistence and commercial purposes also is a...

Internet viruses help ecologists control invasive species

...redation by the spiny water flea causes an average loss of three zooplankton species. Thus, as the species spreads, it could cause loss of thousands of populations of zooplankton species in Ontario alone. ...

A probe, not an echo

...more, or slightly less of the pulse through -- the loss is called "attenuation," and varies according to the type of tissue, and the frequency of the pulse. "Typically the resulting images represent minute variations in relative attenuation over various frequency bands and they define the different secti...

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