Decoding protein structures helps illuminate cause of diabetes
...n trying to understand diabetes, "people have been looking at the fibers, but they should be looking at their formation," he says. "Somehow that mechanism is causing holes [in pancreas cells], which c...Iowa State scientists demonstrate first use of nanotechnology to enter plant cells
...t’s going on inside the cell. We’re on the outside looking in. This gets us inside where we can study the biology per se," Wang said. ...Biodegradable microspheres deliver time release vaccines, stimulate different immune response
... and her colleagues initially began their research looking for a way to eliminate the need for booster vaccinations, by developing a vaccine delivery system that released the vaccine into the system slowly over time. They chose a biodegradable polymer, called polyandydride, in a microsphere formulation. Th......microscopy" to compare healthy brains with others, looking at structure, gene expression and the distribution of different proteins. They will enable better understanding of the organization of normal brains, and could help researchers in identifying fine morphological and chemical abnormalities underlying A...Discovery of 'master switch' for the communication process between chloroplast and nuclei of plants
...Howard Hughes Medical Institute. Koussevitzky, looking at the end of the signaling pathway, found the cor...y be the ‘master switch?that researchers have been looking for." The discoveries are critical to future research efforts in designing new generations of plan...Deconstructing brain wiring, one neuron at a time
...ure out how the machine's electronic chip works by looking down at it; there is no way to figure out how things are connected," Callaway says. "If you were given a wiring diagram, you could begin to understand how the chip moves electricity and how that operates the computer." Neuroscientists also want to...It's never too late to get it back! Aging interrupted
...tterns which are induced by low calorie diets, and looking for drugs which mimic these changes. They are searching for drugs which will have these beneficial effects and slow ageing, even when they are given late in life. One drug, normally used to treat diabetic patients, seems to produce many of the bene...Investigating the measles virus as a tool to kill multiple myeloma
...nti-tumor activity. Dr. Russell’s team also is looking at ways to use the measles virus to combat other cancers, including breast, pancreatic and liver cancer. ...Risk of HIV transmission highest early in infection
... virus as it spreads from one person to another by looking at the evolution of viral genetic material in infected individuals. Drs. Brenner, Wainberg, and colleagues found that 49 percent of early infections formed phylogenetic clusters—very close branches on the family tree. This indicated that a large ...Heart failure: Intervention possibilities from imaging programmed cell loss
... care problem," said Hofstra, "and researchers are looking at novel ways to improve patient care." With heart failure, a person's heart no longer pumps sufficient blood to the body's organs. Nearly 5 million Americans are living with heart failure—a long-term condition that tends to gradually worsen—and 550,...Sandia researchers take new approach to studying how cells respond to pathogens
...rch into how immune cells respond has been done by looking at large cell populations. The Sandia researchers say information gathered from a large population of cells may mask underlying mechanisms at the individual cell level. "Cells have different life cycles, just like any living being. And not all cel...Ancient genes used to produce salt-tolerant wheat
... genes straight away, otherwise we might have been looking for years." The team used their knowledge of the two genes to construct molecular markers, which are now in use in CSIRO's wheat breeding program. A durum wheat variety as salt-tolerant as bread wheat is in advanced field trials and could be comm...Gut research yields new anti-cancer approach
...covery of the anti-cancer effect, researchers were looking for new ways to reduce inflammation seen in Crohn's disease and ulcerative colitis, bowel diseases that cause pain and diarrhea. Specifically, they were comparing the effect on inflammation of encouraging the action of the PPARgamma protein (with act...Veterinary scientists explore poultry virus as cancer killer
... Veterinary Medicine (VMRCVM) at Virginia Tech are looking at how a genetically modified variant of Avian Newcastle disease virus (NDV) can treat human prostate cancer. Dr. Elankurmaran Subbiah, assistant professor in the Department of Biomedical Sciences and Pathobiology, was awarded a prestigious resear...MIT model helps researchers 'see' brain development
...ct abnormal development in diseases like autism by looking at folding differences,?said Fischl. This tool may also be used to shed light on other neurological diseases such as schizophrenia and Alzheimer's disease. ...Hybrid molecule causes cancer cells to self-destruct
...Hopkins team members are expanding their research, looking for new drug-delivery methods and preparing for animal testing. The researchers believe the hybrid molecule will have minimal effect on healthy cells. Through the Johns Hopkins Technology Transfer Office, they have filed an application for a U.S. pat...Nanotechnology meets biology and DNA finds its groove
...uctions for virtually all life, is a twisted knot, looking more like a battered ball of yarn than the famous double helix. To study it, scientists generally are forced to work with collections of molecules floating in solution, and there is no easy way to precisely single out individual molecules for study. ...Synthetic peptide targets latent papilloma virus infections
...nt for the viral infection. "We didn't start out looking for a way to develop a drug, but we stumbled across a way to get the peptide taken up by the cell, and it works," said Voitenleitner. "So far, though, we've only shown that it has a short term effect of releasing the DNA from chromosomes, and this is...A genetic 'gang of 4' drives spread of breast cancer
...r can undergo, and therefore researchers have been looking for specific genes that propel metastasis. In the newly published experiments, the researchers also found that they could reduce the growth and spread of human breast tumors in mice by simultaneously targeting two of the proteins produced by these......e years we'll be finished the animal trials and be looking at clinical trials in humans." Professor Timms said Sanofi-Pasteur's funding would allow QUT to evaluate the effectiveness of Chlamydia prevention methods developed at the university, as well as compare and test possible prevention methods being d...