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Scratch no more: Gene for itch sensation discovered

...s team became interested in GRPR because they were looking for genes in the pain pathway. Among potential pain-sensing genes they identified, GRPR stood out because it is present in only a few nerve cells in the spinal cord known to relay pain and/or itch signals to the brain. So they began to study some mic...

Common cancer gene sends death order to tiny killer

... and genetic medicine. Mendell and his team are looking for missing miR-34a in other cancers. If it's a widespread phenomenon, the work could lead to treatments that aim to restore the missing microRNA to cancer cells. ...

Researchers discover inherited mutation for leukemia

...rapies, working to identify other CLL families and looking for other predisposing genes. In 2005, other Ohio State Comprehensive Cancer Center researchers discovered a germline mutation in a gene for a microRNA that is implicated in CLL, suggesting that this may also be a predisposing mutation for the di...

Cigarette smoke alters DNA in sperm, genetic damage could pass to offspring

... Association for Cancer Research. “Here we are looking at male germline mutations, which are mutations in the DNA of sperm. If inherited, these mutations persist as irreversible changes in the genetic composition of off-spring.” said Carole Yauk, Ph.D., lead author of the study and research scientist in ...

Simulations unravel outer membrane transport mechanism

...aid. “As we get more computational power, we’re looking less at single proteins and more and more at the interaction of proteins,” he said. “And this is going in the direction of what’s called systems biology. This is essential because none of these proteins actually works alone. Each works in concert wit...

Studies to find better ways to preserve human eggs, ovarian tissue under way

...ro fertilization a lot more affordable. Others are looking for ways to ensure there are no cancer germ cells in salvaged tissue. If all goes as hoped with this study, the next step will have Drs. Song and Emmi taking ovarian tissue from cancer patients, vitrifying it then, after they are sure it’s cancer...

New study finds genetically engineered crops could play a role in sustainable agriculture

...s sprayed with insecticides, the Bt crops come out looking quite good. But when Bt crops are compared to crops without insecticides, there are reductions of certain animal groups that warrant further investigation.” What is clear is that the advantages or disadvantages of GM crops depend on the specific goal...

Could fungal collection hold the key to new life-saving drugs?

...This is a really exciting collaboration and we are looking forward to working with the expertise of the scientists at SIDR. We are hopeful that our partnership will prove the winning formula for discovering new pharmaceutical drugs to fight cancers, diseases and resistant strains of infections such as MRSA....

Gene responsible for common hearing loss identified for first time

... SNP (single nucleotide polymorphism) analysis, or looking at DNA sequence variations occurring in a single nucleotide, A, T, C or G, to study a large patient and control population from Belgium and The Netherlands. They found significant results for an amino acid changing SNP inTGBF1, and that this remained...

UCF nanoparticle offers promise for treating glaucoma

... National Science Foundation. Reshetnikov started looking into the possibilities of using nanoparticles as drug delivery tools. Subsequent research with his advisors led to the specific application for glaucoma. In their paper on the research, which was also supported by the National Science ...

Surprising origin of cell's internal highways

... the centrosome," said Kaverina. "So if you're not looking at it precisely, it is hard to distinguish between the centrosome and Golgi." To get a close look, Kaverina and colleagues tagged the growing ("plus") ends of microtubules in human retinal epithelial cells with a fluorescent molecule, videotaped ...

Mule deer moms rescue other fawns

... mule deer as superior mothers, the motivation for looking out for other fawns is likely based not on altruism but on simple survival, said Lingle. "Having a rigid and aggressive response to the simple sound of a fawn distress call may ensure effective defence of a female's own offspring, even though this...

Lessons from the orangutans: Upright walking may have begun in the trees

...ou can't rely on bipedalism to tell whether you're looking at a human or other ape ancestor. It's been getting more and more difficult for us to say what's a human and what's an ape, and our work makes that much more the case." Crompton and his colleagues, Susannah Thorpe and Roger Holder of the Universit...

Resistant HIV quickly hides in infants' cells

...e resistance tests would miss. Earlier studies looking at infants treated with antiretrovirals in an unsuccessful attempt to prevent mother-to-child transmission found the virus quickly developed resistance, but levels of resistant virus declined over time to undetectable levels. In the current study, ho...

Ecology in an era of globalization

...nment explores ecology in an era of globalization, looking at the impacts of human migration, production systems, and invasive species on ecosystems and people throughout North, Central, and South America. Scientists from throughout the Americas gathered last year in Merida Mexico and held a conference on t...

A frown or a smile? Children with autism can't discern

...vity in this region of the brain whether they were looking at faces with a direct or an indirect gaze. “T...thinking,?Davies said. “When responding to someone looking straight at you, as compared to someone who’s looking away, the brain discerns a difference. When th...

Traumas like Sept. 11 make brains more reactive to fear

...ubjects had psychiatric disorders. "We know that looking at fearful faces in normal adults tends to activate the amygdalae relative to looking at neutral faces," said Ganzel. "So we were looking to see if people who have had a very bad experie...

Anthrax paralyzes immune cells with lethal toxin, UF research shows

...cultures that can take days to complete. "We're looking for approaches to detect anthrax earlier in the bl...caped Southwick's research team as well, which was looking for proteins that interacted directly with the toxin. "I would say it's the scientific equivalent...

Scientists identify prion's infectious secret

...misfold—rather like an origami swan that comes out looking and acting instead like a vulture. But prions have another characteristic that enables them to wreak havoc. They recruit other, properly folded proteins into misforming along with them, a process Lindquist calls a "conformational cascade." In many...

LIAI scientists make important finding on cytomegalovirus transmission

...y to the idea that the medical community should be looking at IL-10 as a molecular candidate that might be used to control persistent viral infections." Ware and Croft’s next step will be conducting animal studies with the IL-10 suppression and the OX40 enhancement combined into one treatment. "We tested...

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