Promising new West Nile therapy cures disease in mice
...s or coma. "We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them," says Washington University senior investigator Michael Diamond, M.D., Ph.D., who headed the research team, which is supported in part by the NIAI...Microbial forensics: The next great forensic challenge
...ercial sources. In addition, "A perpetrator can be long gone by the time a disease takes effect, and the original crime scene could be difficult to locate and link to suspects," Murch said. Additionally, the biological and ecological complexity of most biothreat agents present forensic microbiologists wi...Newly discovered pathway might help in design of cancer drugs
...special chemical characteristics and exposed it to long wavelength light that selectively switches on the DNA damage process. He said that the synthetic DNA is very similar to that which is produced when cells are exposed to radiation, with one exception: Greenberg's team's DNA was damaged at only one pl...Buying Time Through Hibernation on Demand
...ancer treatment we're killing off the normal cells long before we're killing off the tumor cells. By inducing metabolic hibernation in healthy tissue we'd at least level the playing field," he said. The delivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with ...U-M team recovers ancient whale in Egyptian desert
...ancer treatment we're killing off the normal cells long before we're killing off the tumor cells. By inducing metabolic hibernation in healthy tissue we'd at least level the playing field," he said. The delivery of such treatment could be as simple as an intravenous infusion of saline solution mixed with ...Love's all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
...?the sex drive, romantic love, and attachment to a long term partner," Fisher said, "and our results suggest how feelings of romantic love might change into feelings of attachment. Our results support what people have always assumed ?that romantic love is one of the most powerful of all human experiences....To control germs, scientists deploy tiny agents provocateurs
...ections in cystic fibrosis patients. Biofilms have long baffled researchers because of their stupefying capacity to behave like a "super-organism" that vetoes the normal characteristics of a bacterial cell in favor of new group behaviors. "It's amazing that such simple organisms as bacteria can form these...Researchers make gains in understanding antibiotic resistance
... the genetic information on messenger RNA into the long strings of amino acids called polypeptides that are used to build the cell's enzymatic machinery. "These antibiotics are clinically very important, and resistance to such antibiotics is a major health problem," said Steitz. "It is becoming critical ...Small species back-up giant marsupial climate change extinction claim
...stralia's past, something integral when developing long term strategies for a sustainable future." ...Defenseless plants arm themselves with metals
... and then we work backwards." A question that has long stymied Salt and his colleagues centers on the origins of this trait. While essential as micronutrients, metals are toxic in high levels. Most plants have mechanisms that keep metals in the environment out of their tissues. So what would have driven ...Mystery Blood Vessel Disorder Implicated In 'Mini' Strokes
Physicians have long been puzzled by a condition called intracranial arterial dolichoectasia, in which the larger arteries of the brain become elongated and misshapen. Typically, it has been considered a complication of atherosclerosis ("hardening of the arteries"), and ...Potential Drug Target For Treating Cocaine Abuse Found
...e of pleasure ?the cocaine high. Researchers have long searched for "a molecule that would block cocaine's effects on the transporter without inhibiting the transporter by itself," notes Eric Nestler, chair of psychiatry at the University of Texas Southwestern Medical Center in Dallas. "This article rep...Study reveals new technique for fingerprinting environmental samples
...ith studying genes important in disease processes, long before the completion of the entire human genome. "EGT fingerprints may be able to offer fundamental insights into the factors impacting on various environments," said DOE JGI Director, Eddy Rubin, who led the research team. "With EGTs we don't actu...Used in a new way, RNA interference permanently silences key breast cancer gene
...he cell population continues to expand. "We are a long way from using this technique in patients, but this study shows that that it may be possible to use RNAi in more than just experiments that silence genes temporarily," says the study's principal investigator, Ralph Arlinghaus, Ph.D., a professor and ...Different microarray systems more alike than previously thought
...ossibility that it may not make much difference as long as the systems are used properly and the results r... used another commercial platform called two-color long oligonucleotide arrays. In general, the study showed Affymetrix GeneChips generated more reproducibl...Study: 'homemade' gene expression technology unreliable
...r, NIEHS-funded study compared a lab-built spotted long oligonucleotide microarray, and a commercially produced long oligonucleotide microarray. The two types were represented among 12 microarray platforms used by sev...Brain-injury rehabilitation depends on acetylcholine circuitry
...ase, and traumatic brain injury. Researchers have long believed that rehabilitation from brain injury causes a rewiring, or plasticity, of brain circuitry--called a "reorganization of cortical motor representations"--to reestablish connections that control muscles. However, the specific type of brain cir...Scientists journey to southern Africa to unravel the secret world of elephant communication
...tunning revelation that elephants communicate over long distances using low-pitched sounds that are barely... their sensitive trunks and feet. Scientists have long known that seismic communication is common in small animals, including spiders, scorpions, insects a...Biomarkers isolated from saliva successfully predict oral and breast cancer
...fluids for molecules that detect early cancers has long been a goal of scientists seeking quick and easy screening tools that could be done in a doctor's office. The search for such tests, however, has been stalled until recently with the advance of several emerging technologies including improved methods...... nitrogen budgets, which play an important role in long term climate predictions, will have to be revised. The discovered nitrogen loss has also consequences for the carbon cycle in marine ecosystems. Denitrification. The measurements refute the dominating theory that oceanic nitrogen loss results from t...