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Tag: "lock" at biology news

Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily

... a molecule called gp120 initially helps the virus lock onto its host T cell, a cell critical for maintaining immunity. Another protein — gp41 — then enables HIV to penetrate a T-cell membrane. Fusion takes place specifically through a short stretch of gp41 called fusion peptide 23, or FP-23 for short. Pr...

Technique monitors thousands of molecules simultaneously

...ypically, receptors bind small molecules through a lock and key mechanism where the molecule is the key and the receptor the lock. The nature and shape of molecules that serve as keys tells about the binding requirements of the receptor. Traditionally, probing a receptor this way has been done by making a...

Alien plants attack using 'resource conservation' as weapon, researchers say

...rces-for example, by mixing sugar into the soil to lock up nutrients or by blocking sunlight with tarps. But these experiments had relatively limited success. "Our results can maybe explain why that method didn't work for all the invasive species," Funk said. Current techniques for fighting invasive sp...

UCLA study uncovers clues for why Graves' disease attacks the eyes

...st latch to a specific receptor ?like a key into a lock -- in order to elicit a cellular response. The receptors mobbed the patients?immune systems, even on T-cells that normally would not produce them. "We didn’t know why GD patients?cells created a new antibody, but had a hunch that that it sprang...

Technology reveals 'lock and key' proteins behind diseases

... iMYTH, they will stain the yeast cell blue. "Like lock and key, if two proteins interact with one another, it is safe to assume they participate or regulate the same cellular process," explains Stagljar. "Identifying new interactors for ABC transporters may reveal unanticipated aspects of how these trans...

Microbes start immune response by sneaking inside cells

...t necessarily rest quietly until invading bacteria lock onto receptors on their outside skins and rouse them to action, as previously thought. In a new paper, University of Michigan scientists describe their findings that bacteria can barge inside these guard cells and independently initiate a powerful im...

Biologically inspired sensors can augment sonar, vision system in submarines

...eces to rotate out of the plane on tiny hinges and lock into place. Each sensor is integrated with metal-oxide-superconductor circuitry for on-chip signal processing, noise reduction and data acquisition. The largest array the researchers have built consists of 16 flow sensors with 1 millimeter spacing....

Common ancestry of bacterium and plants could be key to an effective new treatment for chlamydia

...approach is somewhat like designing a key to fit a lock by opening the lock and looking inside. The research is being done in collaboration with Charles Gilvarg from Princet...

A surprise about our body clock

... molecule called the stem cell factor ?much like a lock and key -- the "turned on" c-kit activates the bone marrow cells to migrate to the heart to help stimulate new blood vessel growth. In the study, mice with defective c-kit bone marrow cells, could not mobilize these cells to race towards the injure...

Healing the heart with bone marrow cells

... molecule called the stem cell factor ?much like a lock and key -- the "turned on" c-kit activates the bone marrow cells to migrate to the heart to help stimulate new blood vessel growth. In the study, mice with defective c-kit bone marrow cells, could not mobilize these cells to race towards the injure...

Structure determined for p53 tumor suppressor protein as bound to DNA for anti-cancer activity

...nd DNA. "So we decided that we needed to somehow lock the protein into a conformation that's compatible with the dimer binding to DNA. We used a chemical trick in which we modified a DNA base to allow it to attach directly to a part of the protein's core domain. That allowed us to trap the form of the p...

ANU scientists crack DNA replication mystery

...flipping over and inserting itself like a key in a lock in a perfectly shaped pocket on the surface of TUS...ntific question, but also because TUS was found to lock onto the DNA very strongly and in an entirely new way." "Strong interactions like this have great p...

Secrets of the sea yield stronger artificial bone

...surface of each layer is rough, helping the layers lock in place with whatever substance fills the space between them. And some bridges form between the layers, which are believed to increase fracture resistance. "These characteristics contribute to the scaffolding's mechanical toughness. Cracks don't pr...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

... to design drugs to bind to the whiskers and or to lock down the flaps by binding to their top. Perryman's first results, which were published in the April 1, 2004, issue of Protein Science, showed that the mechanism of drug resistance seemed to involve the motion of the flaps. More specifically, the do...

Computer simulation hints at new HIV drug target

... to design drugs to bind to the whiskers and or to lock down the flaps by binding to their top. Perryman's first results, which were published in the April 1, 2004, issue of Protein Science, showed that the mechanism of drug resistance seemed to involve the motion of the flaps. More specifically, the do...

Enzyme inhibitors block replication of SARS virus

...searchers have been testing protease inhibitors to lock up this site, known as SARS 3CLpro, and effectively stop the virus from infecting additional cells in the body. In 2004, Wong's lab discovered that Lopinavir, a protease inhibitor of HIV also known as TL3, also served as weak inhibitor of the SARS ...

Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell

...he ZBP1 bound to actin's messenger RNA acts like a lock to prevent it from being translated into protein before reaching its destination," explains Dr. Singer. "On arriving at the cell periphery, the messenger RNA/ZBP1 complex encounters an enzyme, the protein kinase Src, which is active only in that part...

Rodent social behavior encoded in junk DNA

...its as locked rooms, the vasopressin receptor as a lock on the door, and vasopressin as the key that fits it, only those circuits that have the receptors can be 'opened' or influenced by the hormone," added Hammock. "An animal's response to vasopressin thus depends upon which rooms have the locks and our ...

Unexpected lock and key mechanism found for the assembly of tumor blood vessels

A critical lock and key mechanism that allows the final step in th...ate new intact blood vessels, with integrin as the lock and VCAM as the key. Drugs that inhibit either the integrin or the VCAM molecule prevented intact bl...

Natural tumor suppressor in body discovered by UCSD medical researchers

...her molecule that will strip off the phosphate and lock Akt in the "off" position. The scientists conducted a database search of the human genome for a phosphatase, which is an enzyme that acts as a catalyst in regulating cellular processes by removing phosphate molecules. Based on the chemical components...

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