liver 2 6

Tag: "liver" at biology news

U of S researchers develop new vaccine candidate against hepatitis C

... "This offers a very promising approach to prevent liver disease caused by the virus and to ultimately elim...trol the infection." HCV is the leading cause for liver transplants in the western world, and its annual death toll is expected to triple in the next 10 yea...

Gut protein found to protect against infection and intestinal breakdown

...emy of Sciences. Bile, which is generated by the liver and flows into the small intestine via a duct, con...itute isn't a good solution because they can cause liver damage, Dr. Kliewer said. The researchers focused on a molecule ?FXR ?in the wall of the lining, wh...

Retinol for combating leukemia cells

... and pumpkins. This vitamin is accumulated in the liver where it is transformed into retinoid. Given that vitamin A, as such, has no effect on our organism, it is the retinoids that are responsible for the physiological activity of the vitamin. Retinoids take part in three processes: in cell death, in ce...

Dogs keep dying: Many owners unaware of toxic dog food

...rofessor of veterinary medicine who specializes in liver function and disease at the College of Veterinary ...th Diagnostic Center (AHDC) is analyzing blood and liver samples from sick dogs around the country, testing suspected dog food, conducting autopsies and coll...

Cyclosporine inhibits hepatitis C virus in vitro

...ansplantation ). Hepatitis C always recurs after liver transplantation, often damaging the new organ and ...on-ribavirin combination therapy after receiving a liver transplant in hopes of a sustained virologic response. At the same time, of course, the patients mus...

Most human-chimp differences due to gene regulation ?not genes

...omparable, the researchers studied tissue from the liver -- one of the most homogeneous sources -- from fiv...ost stable genes have altered expression levels in liver cancer. When they also looked for human genes with significantly higher or lower expression levels,...

Pennsylvania researchers find liver transplants provide metabolic cure for rare genetic disease

...g in age from 1-20) are alive and well with normal liver function, according to the researchers. Amino acid...97, an MSUD patient at another hospital received a liver transplant due to an unrelated medical condition and physicians noticed the symptoms of her MSUD wer...

Newly discovered killer cell fights cancer

... IKDCs were found in the blood, lining of the gut, liver and other organs - all areas where there is close contact with environmental pathogens. "Here, IKDCs are ready to sense invaders and spring into action," says Housseau. Then, the group tracked the cells to the main messenger center of the immune sy...

Hepatitis C therapy: Inhibiting newly discovered microDNA molecule

..., named miR-122, in order to replicate in cultured liver cells. When the scientists inactivated the microRNA, the amount of hepatitis C virus RNA was reduced by approximately 80 percent. The discovery was widely heralded for its potential to develop new antiviral agents against hepatitis C, the most co...

Weighting cancer drugs to make them hit tumors harder

...o be cleared from the body. They must wait for the liver to break them up and dispose of them via the intestines. "Our goal was to increase the tumor dose and lower the systemic dose," said Chilkoti. "Macromolecular drug carriers are an attractive drug delivery system, because they target tumors and have ...

Predicting successful outcomes in living-donor liver transplants

...ely to have poor outcomes following a living-donor liver transplant (LDLT) found that measuring how a certain non-toxic dye was eliminated by the liver shortly after surgery was an accurate indicator of liver function, and therefore a reliable indicato...

Gene discovery may shed light on kidney disease

... others may have severe, life-threatening heart or liver defects. Both the JAG1 and the NOTCH2 genes part...with kidney disorders. She also will investigate liver involvement in Alagille syndrome under the Rare Diseases Clinical Research Network, recently establi...

Traditional Chinese medicine for diabetes has scientific backing

... in part by activating an enzyme in the muscle and liver that is involved in improving sensitivity of the tissue to insulin ?this in turn helps lower blood sugar levels. In addition, it seems berberine can help reduce body weight". Current medicines for treating type 2 diabetes include metformin and the ...

Speeding discovery of the 'human cancer genome'

...at can--in some circumstances--conspire to produce liver cancer, while the second uncovered a gene importan...es that can work together to encourage one form of liver cancer, called hepatocellular carcinoma. Hepatocellular carcinoma is the fifth most frequent form...

UF scientists test improved gene therapy method for hereditary heart conditions

...a significant amount of its genetic payload to the liver and to other muscles. Because AAV-9 was so readily taken up by cells, a lower dose likely could be used to achieve a therapeutic effect in people, Byrne said. It also has a unique outer shell that helps it break through blood vessel walls so it can...

New pathways for autoimmune treatment identified

...ficantly fewer i NKT cells in the thymus, spleen, liver and bone marrow and severely impaired maturation of those cells in mice missing the Aire gene. And the mice given alpha-GalCer had significantly reduced autoantibody production. In 2001, Dr. Terry L. Delovitch and his colleagues at Canada's Robarts ...

A catalogue of proteins

... In this study, the proteome researchers looked at liver cells in mice. Using mass spectrometry, and by comparing databases, the scientists were able to detect more than 1400 proteins, localised in ten different cell compartments. Previous analyses had shown that certain proteins assign themselves clearly ...

Study finds how organs monitor themselves during early development

...rstood. Feedback loops enable an organ such as the liver to detect if it is injured, ascertain if it is growing and developing normally, and if it needs to regenerate itself. When such loops derail, cancer and other diseases can arise. Scientists at NYU School of Medicine have unraveled the signals in a...

For Stanford scientists, RNAi gene therapy takes two steps forward, one step back

...therapy not on trial - mice in that study suffered liver toxicity from the treatment and some died. Despite... human hepatitis B virus from replicating in mouse liver for more than half a year after a single therapy using this technique. Kay and Grimm said they have ...

Cycles of cell death, proliferation key to liver cancer

...ia, San Diego (UCSD) School of Medicine shows that liver cancer is likely caused by cycles of liver cell death and renewal. The research, appearing online the week of June 19 in advance of publicatio...

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