Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
...xample, it may not tell you what's going on in the liver or the spleen. With this technique, the sensitivity for monitoring the immune system is incredible because you're seeing the whole body." That global perspective makes it possible to see critical ancillary responses in addition to the specific cellu...Sangamo BioSciences demonstrates its ZFP treatment protects cells from HIV infection
...two trials have been halted, one due to reports of liver toxicity of the candidate drug. We believe that using ZFNs to permanently modify the CCR5 gene specifically in T-cells and thus directly block the expression of the protein on the surface of these cells may have several advantages over the systemic ...Common alternative treatment for liver disease is found to be ineffective
...influence on the course of patients with alcoholic liver disease or hepatitis B or C liver disease. These findings are published in The American Journal of Gastroenterology. According to th...Texas scientists discover how a hepatitis C protein promotes liver cancer
...mical connection between the hepatitis C virus and liver cancer. The molecular mechanism is similar to the...mor suppressor' and promoting the proliferation of liver cells, this viral protein is setting up the liver for cancer." According to the federal Centers for...Setting the standard for computer models of life
... for example, a model of alcohol metabolism in the liver would be annotated with links to the protein databases for all the enzymes involved in this pathway, and database links to all the relevant metabolites. The aim of these annotation schemes is to make it easier for researchers to search models on the ...Animal models show that anabolic steroids flip the adolescent brain's switch for aggression
...fer from mood swings, hallucinations and paranoia; liver damage; high blood pressure; as well as increased risk of heart disease, stroke and some types of cancer. Withdrawal often brings depression, and recent research suggests that some AASs may even be habit-forming. Overseen by Richard Melloni Jr., P...Ancient DNA helps UF researchers unearth potential hemophilia therapy
... body. This was unique, Fletcher said, because the liver is generally considered the body's powerhouse for producing the protein needed to keep hemophilia at bay. The study showed that these endothelial cells also can produce enough protein to correct the problem, he said. "I think endothelial cells are p...Liver cancer linked to cellular repair pathway
...opment and the liver's response to injury leads to liver cancer, researchers from Duke University Medical C...d Hedgehog, is present only in immature, stem-like liver cells, the discovery offers hope for targeted treatment of liver cancer, one of the leading causes o...Pain killer fights breast cancer by targeting key enzyme
...nter use in the United States due to rare cases of liver damage and related deaths. "We are working on analogs that will be selective for aromatase expression and also have diminished side effects," Brueggemeier said. "We are obviously in the very early stages of drug discovery with nimesulide analogs, an...Human albumin from tobacco plants
...on or dehydration, chronic infections and renal or liver illnesses. The annual consumption in Spain is about 10 tons but, at a worldwide level, the demand exceeds 500 tons. Agricultural engineer, Alicia Fernández San Millán, has developed a novel technique in Spain - plastidial transformation, in order to...Ocean virus identified in human blood samples
... found most often in the blood of individuals with liver damage, or hepatitis of unknown cause related to b...hat infection with this virus in humans is causing liver damage or some other problems, which may include encephalitis and spontaneous abortion. The viral g...A surprising pair of proteins help make healthy eggs
... certain cancers, including cancer of the skin and liver and in Hodgkin's lymphoma. The new research is the first to connect c-Jun to this network of ovarian genes. Freiman said the discovery reveals a potential connection between TAF4b and c-Jun and the formation of a rare kind of ovarian cancer that spri...Malaria parasites develop in lymph nodes
...ve fully developed, the parasites burst out of the liver cells and infect red blood cells, beginning the on...arasites, blunting the immune system's response to liver and blood-cell infection. "We have to integrate all these new data into something that makes sens...Nanotechnology may find disease before it starts
...les to go to specific locations in the body. "The liver takes up foreign substances in the body, so it's n... Rosol said. "That the particles made it into the liver suggests that they could be used to deliver toxic chemotherapeutic drugs that would act locally on a...Potential vaccine developed for deadly leishmaniasis disease
...clude fever, weight loss, and abnormalities of the liver and spleen. ...International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy
...r complications such as cardiovascular, kidney and liver diseases in the participants on the drug conservation arm. These complications have been associated with ART, and it was hoped that they would be seen less frequently in those patients receiving less drug. Although the risk-to-benefit ratio of dr...New compound protects against liver cancer
...d CDDO-Im that protects against the development of liver cancer in laboratory animals. Experiments, led by researchers at the Johns Hopkins Bloomberg School of Public Health, show CDDO-Im to be effective at doses 100 times lower than other compounds known to prevent cancer in people. Because of its makeup,...Botox could help target resistant tumors for treatment
...dels, one for fibrosarcoma and the other for mouse liver tumor. Botox was injected into the tumor once it had grown to about 6 mm. The tumors were then examined for three days, for vascular and perfusion changes as well as responses to anti-cancer therapies. In tests on oxygenation, cellular oxygen pressur...Basic research leads to a novel cancer therapy
... cancer, esophageal cancer, head and neck tumours, liver cancer, lung cancer, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, and testicular cancer. The studies are in various stages of clinical trials (phases I through III), and most of them are being carried out in combination with other th......ression patterns of samples from colon tumours and liver metastases collected from 13 patients with colorec...ere also confirmed by RT-PCR analysis of colon and liver tumour samples collected from two additional patients. The authors were able to integrate their fi...