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Tag: "liver" at biology news

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

...chers have identified a molecular mechanism in the liver that explains, for the first time, how consuming f...otion by a biochemical switch, or co-activator, in liver cells called PGC-1beta. Until now, scientists lacked a detailed explanation of how saturated and tr...

Priming embryonic stem cells to fulfill their promise

...tem cells to beginthe differentiation process into liver cells. Bhatia, Chien, and Flaimdesigned the techni...e of theknowledge that the extracellular matrix in liver is comprised primarilyof just five proteins. They applied spots of all 32 possiblecombinations of th...

Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer

... contaminated food or water. The disease can cause liver damage but more often causes dysentery, a severe diarrhea that is often associated with blood in the feces. Unchecked, the diarrhea associated with the disease can be fatal, especially in children. One field study in Bangladesh found that E. histolyt...

Tiny particles could solve billion-dollar problem

...toxicity. Human exposure to TCE has been linked to liver damage, impaired pregnancies and cancer. Cleanup costs for TCE nationwide are estimated in the billions of dollars. The Department of Defense alone estimates the cost of bringing its 1,400 TCE-contaminated sites into EPA compliance at more than $5 b...

Scientists Replicate Hepatitis C Virus in Laboratory

...compounds, which may lead to new therapies for the liver disease that results from infection with HCV. Scie...The naked HCV construct was then placed into human liver cells in a cell culture medium. The NIDDK scientists found evidence of HCV proteins and HCV RNA wit...

Gene variations explain drug dose required to control seizures

...variant of a gene known as CYP2C9, which encodes a liver enzyme involved in drug metabolism, showed a significant association with the maximum dose of phenytoin taken by patients with epilepsy. Moreover, a variant of a second gene, called SCN1A, with activity in the brain, was found significantly more oft...

Studies reveal methods viruses use to sidestep immune system

...HCV disrupts a separate immune pathway in infected liver cells, again by unleashing the NS3/4A protease to ... contact and is the leading cause of cirrhosis and liver cancer. UT Southwestern Medical Scientist Training Program (MSTP) student Eileen Foy was an author ...

Potential Cure for Lymphoma in HIV patients

... greater than 5?10 cm).Reversible abnormalities in liver function, a side effect of theintensive treatment, were experienced in a majority of the patients.One patient, the oldest in the study, developed cardiomyopathy (aweakening of the heart) and kidney failure due to treatment toxicitiesand died a few we...

Research Gives Hope For Liver Damage

...-saving treatments. There is currently no cure for liver cirrhosisand a patient's only hope of survival is to receive a liver transplant.The Edinburgh scientists from the University's Centre for InflammationResearch, in collab...

Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells

...rate, real-time, high-throughput identification of liver tumor cells at their earliest stages, and without invasive chemical reagents. The technique generates a laser beam in single human cells pumped from a flask through tiny microchannels. The beam is altered by what it encounters. These changes, regist...

Effective Cancer Treatments Follow The Clock

...me of the enzymes involved in activating CY in the liver show circadian rhythms,?said Takahashi. “We thought that the liver might be activating the drug more strongly at some times, or detoxifying it less effectively, or bot...

Surprising findings reported about iron overload

...t in complications such as cirrhosis of the liver, liver cancer, arthritis, diabetes, impotence and heart f...e HFE gene were more likely to report a history of liver disease than participants without HFE mutations. "Our findings in Caucasians confirm reports from p...

World-first Living Donor Islet Cell Transplant A Success; Procedure Offers Promise For Diabetics

...Kyoto, Japan, where he originally did living donor liver transplant training with Dr. Tanaka. Dr. Masumoto ... and living donation has very established roots in liver and kidney transplantation there. "Living donor islet transplants could allow many more desperate p...

Norovirus, AIDS vaccine and Hepatitis Virus

...that infect the liver, and in some cases can cause liver failure requiring a transplant for survival. The protein interferon, produced by animal cells when they are invaded by viruses, is released into the bloodstream or intercellular fluid to induce healthy cells to manufacture an enzyme that counters the...

PET/MRI scans may help unravel mechanisms of prenatal drug damage

...eart, kidneys and lungs, with slower uptake in the liver and brain. In the fetus, cocaine accumulated at the highest levels in the liver (due to the unique anatomy of fetal circulation) and to a lesser extent in the brain. "While the up...

Antiretroviral therapy may prevent excess risk of some cancers in people with HIV

...of anal cancer, Hodgkin lymphoma, cervical cancer, liver cancer, cancer of the lip, mouth, and pharynx, and non-melanoma skin cancer. People who used HAART had lower risks of Kaposi sarcoma and non-Hodgkin lymphoma compared with those who did not use HAART, although even with HAART these tumors occurred 20...

Iron exporter revealed that may explain common human disorder

...ther metals, iron cannot be eliminated through the liver or kidneys, Andrews explained. Iron balance is mai...and recycle the iron they contain. Macrophages and liver cells also store any excess iron. Earlier work had identified a single protein that imports iron in...

Gene Therapy Cures Inherited Liver Disease In Rats

...f gene-virus combination cured rats of a inherited liver disease in which lack of a gene causes the accumulation of bilirubin –which, untreated, results in jaundice and brain damage, said researchers at Baylor College of Medicine in a report in the Proceedings of the Natural Academy of Sciences. "This is ...

Anti cancer virotherapy well tolerated in first human administration, research finds

...f the viral material and basic blood chemistry and liver enzyme levels remain unchanged in the these two patients. Professor Shafren told conference delegates that these findings suggested that administration of a single dose of CVA21 directly into a cancerous tumour was well tolerated. "Administration o...

Protein That Promotes Survival Of Stem Cells Might Be Key To Poor Leukemia Prognosis

... with the gene continued to flourish. In contrast, liver cells were unaffected following loss of Mcl-1, demonstrating that Mcl-1 is important only in certain cell types. Finally, the investigators showed that growth factors (natural proteins that stimulate cells to grow), such as the "stem cell factor," tr...

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